Acute ureteral obstruction secondary to mucoid impaction in supravesical diversion

The role of mucoregulatory agents after continence-preserving urinary diversion surgery

“…For example, N-acetylcysteine, an injectable mucolytic agent used to clear bronchial secretions, is reported to have demonstrated efficacy in reducing mucus accumulation in patients with urinary diversions. 13,14 Other therapies used to reduce mucus production or urine viscosity (or both) in patients with urinary diversion include oral ranitidine, oral aspirin, urine-pouch instillations of a urea solution, and subcutaneous octreotide. Ranitidine, a histamine H 2 -receptor antagonist, reduces mucus production through an undetermined mechanism of action.…”

“…In 1974, Caponegro and Leadbetter 13 reported the case of a 25-yearold man who had undergone the placement of a urinary sigmoid conduit and developed a mucous plug obstruction. Instillations of a mixture of 15 mL of 0.9% sodium chloride injection and 15 mL of N-acetylcysteine (concentration not specified) were placed into the conduit via a urinary catheter for one hour, and the treatment was repeated eight hours later.…”