Acute Unilateral Blindness from Superior Ophthalmic Vein Thrombosis: A Rare Presentation of Nephrotic Syndrome from Class IV Lupus Nephritis in the Absence of Antiphospholipid or Anticardiolipin Syndrome

Baidoun, Firas; Issa, Rommy; Ali, Robert; Al-Turk, Bashar

doi:10.1155/2015/413975

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…There are several reported cases of SOVT in SLE with and without antiphospholipid syndrome. The SOVT in SLE without antiphospholipid syndrome is attributed to inflammation and SOVT in SLE with the antiphospholipid syndrome is attributed to hypercoagulation [[13], [14], [15]]. There is an association between the systemic malignancies (leukemia, lymphoma, multiple myeloma, lung cancer and amyloidosis) and the SOVT [[3], [4], [5], [6],16,17].…”

Section: Discussionmentioning

confidence: 99%

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Sotoudeh

Shafaat

Aboueldahab

et al. 2019

European Journal of Radiology Open

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Superior ophthalmic vein thrombosis (SOVT) is an extremely rare condition. Few studies have been published about clinical aspects of this condition. In this study, we have studied the symptoms, underlying etiologies, treatment, pathogenesis and complication of the SOVT and we tried to classify it based on the etiology, treatment, and prognosis. Methods: We reviewed the patients' data from a tertiary academic referral center. Each patient with SOVT was then reviewed for symptoms associated with SOVT, underlying etiology, treatment protocol, treatment response, complications, possible pathogens, and final outcome. Results: Twenty-four cases of SOVT were included in this study. Overall, 13 cases were diagnosed as right-sided SOVT, out of which, eight had simultaneous right-sided cavernous sinus thrombosis (CST). Eighteen cases were diagnosed to have left-sided SOVT, out of which, 11 had simultaneous left-sided CST. Conclusions: The SOVT can be secondary to different mechanisms. The SOVT secondary to trauma, recent surgery and coagulopathy are mostly non-aggressive, and can be managed by conservative therapy and anticoagulation. The SOVT in patients with orbital cellulitis, history of active sinusitis or paranasal sinus surgery are aggressive presenting with acute orbital swelling, abscess and visual loss. This type of SOVT can be complicated by extension to the cavernous sinus and intracranial structures. These patients require urgent antibiotics therapy and sinus surgery. The most severe type of SOVT is caused by mucormycosis which may also extend intracranially resulting in stroke and is often life-threatening.

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Section: Discussionmentioning

confidence: 99%

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Sotoudeh

Shafaat

Aboueldahab

et al. 2019

European Journal of Radiology Open

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“…10,11 Some systemic diseases have been reported in association with SOVT like systemic lupus erythematosus, Graves disease, ulcerative colitis etc. [12][13][14][15][16] Other causes are hematologic like antiphospholipid syndrome, sickle cell disease, hormonal causes like tamoxifen, oral contraceptive pills etc, Tolosa-Hunt syndrome, idiopathic orbital inflammatory disease. [17][18][19][20][21][22][23][24][25] In a case series by Nicolien et al 3 the majority of the patients were aseptic (seven out of nine) although all the patients in this case series were adults.…”

Section: Discussionmentioning

confidence: 99%

Superior Ophthalmic Vein Thrombosis with Cerebral Venous Sinus Thrombosis: A Rare Entity in a Child

Fatema¹,

Rahman²,

Banu³

2019

J Enam Med Col

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Cerebral venous sinus thrombosis (CVST) is a rare stroke-like syndrome. Sometimes it may be rarely associated with ophthalmic vein occlusion. We present a 10-year-old girl who had severe headache, diplopia, severe congestion of eye, proptosis and orbital pain. She had no signs of meninigeal irritation, no focal deficit except left sided lateral rectus palsy and altered visual acuity. Investigations regarding vasculitis and thrombophillia were normal except thrombocytosis. MRI of brain showed ‘dense triangle sign’ and thickened superior ophthalmic vein. Magnetic resonance venography (MRV) showed occlusion of superior sagital sinus and transverse sinus. She was treated with paracetamol, acetazolamide, rivaroxaban and antibiotics followed by high dose pulse methyl prednisolone. She made a partial recovery within one week and at 3 months follow-up she was completely normal. J Enam Med Col 2019; 9(2): 127-132

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“…[6][7][8] Systemic diseases reporting SOVT in literature include Graves' Orbitopathy, systemic lupus erythematosus, and ulcerative colitis. [9][10][11][12][13] Hematologic aetiologies include antiphospholipid syndrome and sickle trait. [14][15][16][17] Also, hormone therapies have been reported as a cause for SOVT (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25][26] On the other hand, in some cases SOVT can be the first clinical sign of a new diagnosis such as arteriovenous fistulae or systemic disorders. 11,12 Septic causes of SOVT include infections of the paranasal sinuses, orbit, teeth, and face. In literature, paranasal sinusitis is the most common cause of septic SOVT.…”

Section: Discussionmentioning

confidence: 99%

Impact of superior ophthalmic vein thrombosis: a case series and literature review

Poel

Witt

Berg

et al. 2018

Orbit

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Acute Unilateral Blindness from Superior Ophthalmic Vein Thrombosis: A Rare Presentation of Nephrotic Syndrome from Class IV Lupus Nephritis in the Absence of Antiphospholipid or Anticardiolipin Syndrome

Abstract: Patients with systemic lupus erythematosus (SLE) are at high risk of arterial and venous thrombosis secondary to anti-phospholipid antibodies. Herein, we are presenting an interesting case of venous thrombosis in a patient with SLE in the absence of anti-phospholipid antibodies.

Cited by 9 publications

References 4 publications

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Superior Ophthalmic Vein Thrombosis with Cerebral Venous Sinus Thrombosis: A Rare Entity in a Child

Impact of superior ophthalmic vein thrombosis: a case series and literature review

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