Acute undifferentiated leukaemia in a dog

Miglio, Arianna; Antognoni, Maria Teresa; Miniscalco, Barbara; Caivano, Domenico; Lepri, Elvio; Birettoni, Francesco; Mangili, V.

doi:10.1111/avj.12273

Cited by 15 publications

(13 citation statements)

References 21 publications

(50 reference statements)

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“…Często niezwykle trudne jest odróżnienie nowotworowych komórek blastycznych hematopoezy od limfoblastów, mieloblastów, monoblastów, proerytroblastów/rubiblastów czy megakarioblastów (13,14,23). W związku z powyższym, w wielu przypadkach (w hematoonkologii medycznej jest to standardem) do prawidłowego rozpoznania wymagane jest wdrożenie dodatkowych metod identyfikacji komórek rozrostu, między innymi immunocytochemii, cytometrii przepły-wowej i badań genetycznych (1,6,10,16,(18)(19)(20)25).…”

Section: Wyniki I Omówienieunclassified

“…Zgodnie z danymi piśmiennictwa (16), białaczki ostre rozpoznaje się czę-ściej u psów rasowych niż u mieszańców, wydaje się też, że szczególnie predysponowane są psy ras dużych i olbrzymich. W badaniach własnych wykazano wyraź-ną predyspozycję owczarków niemiecki oraz golden retrieverów, co z pewnymi wyjątkami wykazali też inni autorzy (1,8,12,14,16). Przykładowo wyraźną predyspozycję golden retrieverów do występowanie ALL stwierdzili Adam i wsp.…”

Section: Wyniki I Omówienieunclassified

“…Praktycznie we wszystkich przypadkach szpik kostny był bogatokomórkowy i zawierał absolutną dominację komórek nowotworowych, dzięki czemu rozpoznanie było stosunkowo proste. Chociaż wiarygodne rozpoznanie ostrej białaczki można postawić na podstawie stwierdzenia, że minimum 20-30% komórek szpiku to komórki blastyczne, to w zdecydowanej większości opisywanych przypadków liczba blastów jest zdecydowanie wyższa i często osiąga od 70% do 90% wszystkich komórek jądrzastych szpiku kostnego (10,14,15,21). W prezentowanych badaniach podczas oceny cytologicznej szpiku kostnego prawidłowe komórki hematopoezy były obserwowane rzadko, niekiedy nie były one nieobecne, co uznaje się z typową cechę ostrych białaczek u psów (10).…”

Section: Wyniki I Omówienieunclassified

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Acute leukemias in dogs: Analysis of 31 cases.

Sapierzyński¹,

Hutsch²,

Czopowicz³

et al. 2017

Medycyna Weterynaryjna

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SummaryThe aim of the present study was to analyse epidemiological, cytological, laboratory and clinical data from canine acute leukemia (AL) cases. The study was conducted from 2009 to 2015, and included 2384 dogs undergoing cytological examination in two veterinary practices in Warsaw. The analysis included dogs in which bone marrow cytology revealed acute leukemia, regardless of its subtype. Data on breed, age, sex, as well as clinical signs and results of haematological examination were collected for every dog. Breed predisposition to acute leukemia was calculated by statistical methods on the basis of the theoretical distribution of canine breeds in Poland. Acute leukemia was diagnosed in 31 dogs (24.7%) undergoing bone marrow cytology, that is, in 1.3% of all the dogs examined by cytology during the study period. The disease was diagnosed mainly in adults, and a strong predisposition was found particularly in German shepherds and Golden retrievers. The median duration of clinical signs from the onset to diagnosis was 14 days. The clinical signs were mostly non-specific (apathy, recurrent fever, lack of appetite), whereas lymphadenomegaly or/and splenomegaly were observed more seldom. Hematology revealed neoplastic leukocytosis in 75% of dogs, whereas anemia and trombocytopenia were observed in 86% and 85% of patients, respectively. Regardless of the leukemia subtype, prognosis was poor. In conclusion, it can be stated that according to current knowledge on canine acute leukemias, bone marrow cytology based on routine staining methods is sufficient for correct diagnosis in a vast majority of cases.

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Section: Wyniki I Omówienieunclassified

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Acute leukemias in dogs: Analysis of 31 cases.

Sapierzyński¹,

Hutsch²,

Czopowicz³

et al. 2017

Medycyna Weterynaryjna

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“…A case report of an 8-year-old German Shepherd dog describes a rare case of acute undifferentiated leukaemia (AUL). 7 The dog was presented with a 2-week history of depression, weakness, anorexia and progressive weight loss. Haematology analysis revealed mild anaemia and thrombocytopenia and marked leucocytosis.…”

Section: Small Animalsmentioning

confidence: 99%

In this issue – December 2014

Jackson¹,

Cabral²

2014

Aust Veterinary J

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“…; Miglio et al . ; Stokol et al . ), but only very few reports are described in horses (Rendle et al .…”

Section: Introductionmentioning

confidence: 99%

Subleukaemic acute myeloid leukaemia with myelodysplasia in a horse

Miglio

Pepe

Felippe

et al. 2018

Equine Veterinary Education

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Summary Acute myeloid leukaemia (AML) is rarely reported in horses and myelodysplastic syndrome (MDS) has been described only in one case. Acute myeloid leukaemia is defined as the presence of at least 20% blasts in the marrow or blood. On the other hand, MDS is characterised by morphologic abnormalities in one or more cell lineages with hypercellular marrow and peripheral cytopenias due to ineffective haematopoiesis. We report a case of acute myelomonocytic leukaemia with myelodysplasia‐related features in a horse. A supposed diagnosis was based on abnormal morphology of circulating neoplastic cells and bone marrow cytology. A final diagnosis was made by using flow cytometry (FC) in conjunction with cytochemistry (CC) rarely reported in the haematopoietic neoplasms of the horse.

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Acute undifferentiated leukaemia in a dog

Cited by 15 publications

References 21 publications

Acute leukemias in dogs: Analysis of 31 cases.

Acute leukemias in dogs: Analysis of 31 cases.

In this issue – December 2014

Subleukaemic acute myeloid leukaemia with myelodysplasia in a horse

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