ACUTE TOXICITY TEST OF LOW CALCIUM OXALATE PORANG (Amorphophallus mueleri BLUME) FLOUR

Donowarti, Idiek; Widjanarko, Simon Bambang; Yunianta, Y.; Pudjiastuti, Pratiwi

doi:10.36103/ijas.v52i1.1253

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Greater than 15,000 mg/kg BW porang flour dosage caused liver cell damage in white rats, and hyperactivity among the female rats was also observed [108] APME and APAE tuber >2000 mg/kg Swiss albino mice No toxicological property was reported at the doses tested…”

Section: Safety and Toxicity Studiesmentioning

confidence: 95%

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Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

Islam,

Labib,

Zehravi

et al. 2023

Plants

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The genus Amorphophallus belongs to the family Araceae. Plants belonging to this genus are available worldwide and have been used in traditional medicines since ancient times, mainly in Ayurveda and Unani medical practices. Amorphophallus species are an abundant source of polyphenolic compounds; these are accountable for their pharmacological properties, such as their analgesic, neuroprotective, hepatoprotective, anti-inflammatory, anticonvulsant, antibacterial, antioxidant, anticancer, antiobesity, and immunomodulatory effects, as well as their ability to prevent gastrointestinal disturbance and reduce blood glucose. Moreover, Amorphophallus species contain numerous other classes of chemical compounds, such as alkaloids, steroids, fats and fixed oils, tannins, proteins, and carbohydrates, each of which contributes to the pharmacological effects for the treatment of acute rheumatism, tumors, lung swelling, asthma, vomiting, abdominal pain, and so on. Additionally, Amorphophallus species have been employed in numerous herbal formulations and pharmaceutical applications. There has been no extensive review conducted on the Amorphophallus genus as of yet, despite the fact that several experimental studies are being published regularly discussing these plants’ pharmacological properties. So, this review discusses in detail the pharmacological properties of Amorphophallus species. We also discuss phytochemical constituents in the Amorphophallus species and their ethnomedicinal uses and toxicological profiles.

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Section: Safety and Toxicity Studiesmentioning

confidence: 95%

“…Porang flour doses greater than 15,000 mg/kg b.w. caused liver cell damage in white rats and hyperactivity in female rats [108]. There was no toxicity or adverse effects observed in Swiss albino mice when administered with more than 2000 mg/kg of methanolic and aqueous A. paeoniifolius tuber extracts (Table 4) [109].…”

Section: Safety and Toxicity Studiesmentioning

confidence: 96%

Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

Islam,

Labib,

Zehravi

et al. 2023

Plants

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Analisis Histologi dan Scaning Elektron Mikroskopy (SEM) pada Somatik Embriogenesis Tanaman Porang (Amorphophallus muelleri B)

Hariyanto¹,

Handoyo

Dewanti

et al. 2022

Agriprima

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Pembentukan Somatik Embriogenesis (SE) porang secara tidak langsung memiliki proses yang lambat, selama ini yang digunakan adalah induksi secara langsung karena dapat mempercepat penyediaan bibit tetapi pengetahuan tentang induksi SE secara tidak langsung sangat dibutuhkan untuk mengetahui tahapan perkembangannya. Kami menyajikan pengetahuan terkait interaksi hormon 2,4-D dan NAA terhadap induksi kalus, histologi dan scanning elektron microscop (SEM) kalus embriogenik tanaman porang (Amorphophallus muelleri). Tujuan penelitian ini adalah guna mengetahui interaksi pengaruh 2,4-D dan NAA dalam proses induksi SE dan mempelajari tahapan perubahan embrio serta perkembangan struktur embrio tanaman porang. Penelitian ini telah dilangsungkan selama 6 bulan sejak Mei hingga Oktober 2021. Tempat penelitian berada di Laboratorium Kultur Jaringan Agronomi Fakultas Pertanian Universitas Jember. Penelitian ini mengunakan Rancangan Acak Lengkap (RAL) 2 Faktor dengan 3 kali ulangan. Faktor pertama ialah hormon 2,4-D dengan konsentrasi 0 ppm, 1 ppm, 2 ppm, dan faktor kedua yaitu hormon NAA dengan konsentrasi 0,5 ppm, 1 ppm, 1,5 ppm, 2 ppm, 2,5 ppm, kemudian data yang didapatkan dilakukan analisis deskriptif dan ANOVA. Hasil penelitian menunjukan perlakuan hormon 1 ppm 2,4-D dan 1,5 ppm NAA menghasilkan kalus embriogenik dan pada hasil histologi dan scaning electron mikroskopy (SEM) memperlihatkan tahapan embrio somatik porang meliputi tahapan proembrio, embrio globular, skutelar dan kolioptilar, lalu tahap koleoptilar berkembang ke tahap primodial tunas. Pada konsentrasi 1 ppm 2,4-D dan 1,5 ppm NAA terbentuk proembrio dan embrio globular yang memiliki permukaan proembrio yang halus.

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Acute Toxicity Study of Porang (Amorphophallus oncophyllus) Flour Macerated with Strobilanthes crispus in Wistar Rats

A’yun¹,

Hasanah²,

Hadi

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Porang (Amorphophallus oncophyllus) is a local tuber food that high in bioactive compound glucomannan. It uses are limited due to oxalate acid content which poses health risks. Strobilanthes crispus leaves could reduce the level of calcium oxalate in porang. However, there is still no study to prove its safety. AIM: This study aimed to investigate the acute oral toxicity study of porang (A. oncophyllus) macerated with S. crispus based on observation of mortality rate (LD50), the changes in behavior during 72 h, renal and hepatic function such as urinary protein, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT) levels of Wistar rat (Rattus norvegicus) METHODS: An acute toxicity test was conducted based on the Organization of Economic Co-Operation and Development 420 Fixed-Dose Procedure Guideline that consists of preliminary and main studies. For the preliminary study, rats were divided into control and five treatment groups with the dosage of 50, 300, 2000, and 5000 mg/kg body weight (BW) for each natural porang flour (NPF) and S. crispus-macerated porang flour (SPF). For the main study, rats were divided into four groups, those were NPF and SPF with the dosage of 2000 and 5000 mg/kg BW. Levels of urinary protein and blood serum SGOT and SGPT levels were measured at 0, 24, and 72 after treatment. RESULTS: The acute toxicity study showed that porang and porang macerated with S. crispus were not toxic until the highest dose of 5000 mg/kg BW. It was proved by the absence of LD50, no change in behavior, no weight losses, and also the results of biochemical tests, such as urinary protein, SGOT, and SGPT which were still in the normal range. CONCLUSIONS: Porang flour and SPF were concluded as non-toxic food based on acute toxicity study.

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ACUTE TOXICITY TEST OF LOW CALCIUM OXALATE PORANG (Amorphophallus mueleri BLUME) FLOUR

Cited by 4 publications

References 21 publications

Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

Analisis Histologi dan Scaning Elektron Mikroskopy (SEM) pada Somatik Embriogenesis Tanaman Porang (Amorphophallus muelleri B)

Acute Toxicity Study of Porang (Amorphophallus oncophyllus) Flour Macerated with Strobilanthes crispus in Wistar Rats

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