Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Yuandani, Yuandani; Suwarso, Edy

doi:10.22159/ajpcr.2017.v10i1.16196

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Levamisole was used as a positive control. The result was in accordance with the previous study which showed the ability of C. mangga methanol extract to increase the phagocytosis response by in vitro and in vivo study 14,20 .…”

Section: Analysis Of Compounds and Mmunostimulatorysupporting

confidence: 92%

“…Quercetin is in the class of flavonoids which has been reported to have antioxidant activity 13 . Our in vivo study reported that C. mangga increased phagocytosis ability of mice leukocytes 14 . However, it is necessary to elaborate its immunomodulatory activity on adaptive immunity.…”

Section: Analysis Of Compounds and Mmunostimulatorymentioning

confidence: 74%

“…Levels of antibody in serum can be determined as antibody titres. The antibody was cross-linked with red blood cells leading to agglutination 14 . Antibody titres expressed as the reciprocal of the highest dilution of the sample that still causes agglutination 21 .…”

Section: Humoral Antibody Titrementioning

confidence: 99%

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Analysis of Compounds and Immunostimulatory Properties of Curcuma Mangga Rhizomes on Male Mice

Yuandani¹,

Yuliasmi²,

Satria³

2018

RJC

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The current study was carried out to determine the constituents in ethanol extract of Curcuma mangga rhizomes and its immunostimulatory effects of the extract on cellular and humoral immunity of male mice. Determination of constituents in the extract was conducted using Ultra Performance Liquid Chromatography. The ethanol extract of Curcuma mangga was comprised to delayed-type hypersensitivity response and haemagglutinating antibody titre tests for its immunostimulatory potential. The test animal received extract at doses of 100, 200 and 400 mg/kg BW for 7 days after sensitized by bovine Red Blood Cells. Cellular response was measured by increase of paw volume, meanwhile humoral antibody response was determined by hemagglutination method. Quercetin was determined quantitatively in the extract by a validated reversed phase Ultra Performance Liquid Chromatography method. The footpad thickness and antibody titre of male mice after treatment with ethanol extract of Curcuma mangga were significantly higher as compared to negative control (P<0.05). The extract of Curcuma mangga at a dose of 400 mg/kg BW depicted stronger immnumostimulatory activity as compared to positive control. The result indicates that the ethanol extract of Curcuma mangga shows immunostimulatory activity, emphasizing its potential to be developed as a therapeutic agent.

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Section: Analysis Of Compounds and Mmunostimulatorysupporting

confidence: 92%

Section: Analysis Of Compounds and Mmunostimulatorymentioning

confidence: 74%

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Analysis of Compounds and Immunostimulatory Properties of Curcuma Mangga Rhizomes on Male Mice

Yuandani¹,

Yuliasmi²,

Satria³

2018

RJC

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“…The antiinflammatory, immunomodulatory, antifungal, anticancer and nitric oxide inhibitory activities of C. mangga have also been reported [11][12][13][14] . Safety assessment revealed that it was untoxic in show short-term treatment 15 . The previous study has also shown the immunomodulatory properties of C. mangga 16 .…”

Section: Introductionmentioning

confidence: 99%

CORRELATION BETWEEN THE PHYTOCHEMICAL CONSTITUENTS OF Curcuma mangga AND ITS IMMUNOMODULATORY EFFECT

Yuandani¹,

Yuliasmi²,

Satria³

et al. 2019

RJC

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The present study was conducted to correlate between the phytochemical constituents in the extract of C. mangga rhizomes and its immunomodulatory effect on phagocytosis of mice leukocytes. The phytochemical screening was performed using the standard method, while qualitative analysis of curcumin in C. mangga extract was examined using Thin Layer Chromatography (TLC). The n-hexane, ethyl acetate and ethanol extracts of C. mangga were introduced to carbon clearance method for their immunomodulatory potential. The phytochemical screening on nhexane and ethanol extracts of C. mangga rhizomes revealed the presence of steroids and terpenoids. Meanwhile, glycosides, saponins and flavonoids were detected in ethyl acetate and ethanol extracts. The TLC analysis led to the identification of curcumin in all extracts. All the samples tested demonstrated the immunostimulatory effect on phagocytosis ability of mice leukocytes. Of all the extracts, n-hexane extract displayed the strongest stimulation on phagocytosis effect but there was no significantly different (P>0.05). The results suggest that the immunostimulatory activity of extract on phagocytosis ability was due to the presence of its major constituents although other constituents may also contribute.

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FORMULATION AND EVALUATION OF HERBAL CAPSULE CONTAINING CURCUMA MANGGA VALETON and ZIJP. EXTRACT AND ITS IMMUNOSTIMULATORY EFFECTS

YUANDANI,

LAILA,

NUGRAHA

et al. 2023

Int J App Pharm

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Objective: The present study was carried out to formulate and evaluate C. mangga extract as granule mass in a capsule dosage form as well as investigate its immunostimulatory effects. Methods: The granule mass was evaluated for its bulk density, tapped density, Carr’s index, Hausner ratio, angle of repose, and flow ability. Meanwhile, capsule weight and disintegration time were determined to evaluate the C. mangga capsule. The immunostimulatory effects of extract in capsule dosage form were investigated by measuring delayed-type hypersensitivity (DTH) response and IgG production. There were six formula prepared (F1-F6). Formula F1-F6 were vary according to the component of adsorbent (Corn starch/polyvinyl pyrrolidone) and filler (maltodextrin/Avicel/lactose) to obtain the optimum formula. Results: The granule mass of all formula had a good flow ability and free-flowing properties according to the Carr’s index (10.26±3.38 to 17.54±1.60) and flowing time (1.05±0.05 to 1.60±0.08 seconds). Of all the capsule formula, F2 capsule containing dry extract of C. mangga with Avicel as the filler met the standard requirement in terms of disintegration time (2.15±0.76 min) and weight uniformity (the deviation was below than 7.5%). The capsule of C. mangga extract enhanced the paw thickness as compared to those of the negative control (P<0.05). The level of Immunoglobulin G (IgG) was also increased after treatment with the capsule of C. mangga extract. Conclusion: The results suggest that the capsule of C. mangga extract has immunostimulatory effects, emphasizing its potential to be used for the treatment of infectious and immunodeficiency diseases.

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Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Cited by 5 publications

References 11 publications

Analysis of Compounds and Immunostimulatory Properties of Curcuma Mangga Rhizomes on Male Mice

Analysis of Compounds and Immunostimulatory Properties of Curcuma Mangga Rhizomes on Male Mice

CORRELATION BETWEEN THE PHYTOCHEMICAL CONSTITUENTS OF Curcuma mangga AND ITS IMMUNOMODULATORY EFFECT

FORMULATION AND EVALUATION OF HERBAL CAPSULE CONTAINING CURCUMA MANGGA VALETON and ZIJP. EXTRACT AND ITS IMMUNOSTIMULATORY EFFECTS

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