Acute Toxicity Determination Of Two New Benzothiazino Phenoxazine Dyestuffs In Mice

Analysis and Acute Toxicity Determination of the Dyestuff in the Effluent of a Textile Manufacturing Company Located In The Eastern Part of Nigeria

“…The dyes contained in the effluent investigated are non toxic , because in an LD 50 toxicity test done on 4461 colourants, no toxicity was quoted for 44 colourants which had LD 50 < 250 mg/kg while 3669 exhibited practically no toxicity i.e. LD 50 above 250 mg/kg (6,7). Since the doses of 300mg/kg, 400mg/kg and 500mg/kg of the extract dye used in the LD 50 test caused no signs or death of the experimental mice, it concludes that the dyes are non toxic.…”

“…There are two types of toxicity test available-Acute toxicity by LD 50 and by the Fixed Dose Procedure requiring fewer animals; the other method is the long -term toxicity test, which deals with the teratogenicity and carcinogenicity of the compounds (6).…”

“…Dyes and pigments have to be screened for toxicity since they find their way into the human body through materials such as clothing, hair dye, and also by injestion (6). In order to minimize the possible damage to man and the environment, an international Association of Dyestuff Manufacturing industry (ETAD) was founded in 1974.…”