Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase II Study—The IPI Trial

Habl, Gregor; Uhl, Matthias; Katayama, Sonja; Kessel, Kerstin A.; Hatiboglu, Gencay; Hadaschik, Boris; Edler, Lutz; Tichy, Diana; Ellerbrock, M.; Haberer, Thomas; Wolf, MB; Schlemmer, Heinz Peter; Debus, Jürgen; Herfarth, Klaus

doi:10.1016/j.ijrobp.2016.02.025

Cited by 53 publications

(60 citation statements)

References 24 publications

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“…It should be noted that whilst a number of clinical studies have reported hydrogel spacers to be safe [3,6], one published case report linked a rectal ulcer to a hydrogel insertion [28] and their use was halted in a recent trial, where two rectal fistulas were presumed due to the gradual accumulation of gel within the confines of the anterior rectal wall, as seen on magnetic resonance imaging during the course of the treatment [29]. However, the latter publication reported that in addition to gel migration, variations in individual patient radiosensitivity could have played a role, on-treatment image guidance was limited to orthogonal x-rays (it did not state whether alignment based on bony anatomy or prostate fiducials), and the in vivo dose to the anterior rectal wall was not known precisely [29].…”

Section: Discussionmentioning

confidence: 99%

“…However, the latter publication reported that in addition to gel migration, variations in individual patient radiosensitivity could have played a role, on-treatment image guidance was limited to orthogonal x-rays (it did not state whether alignment based on bony anatomy or prostate fiducials), and the in vivo dose to the anterior rectal wall was not known precisely [29]. The quality of the initial gel placement was not described and ultimately the exact source of the fistulas remains unknown.…”

Section: Discussionmentioning

confidence: 99%

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Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams

et al. 2017

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“…LNCaP cells were seeded into 6-well plates at a density of 1x10 5 cells/well, in triplicate, prior to treatment with 0, 0.1, 1 and 10 µM cucurbitacin E for 24 h. Cells were lysed on ice in radioimmunoprecipitation assay lysis buffer (Beyotime Institute of Biotechnology, Haimen, China) and homogenized. Total protein concentration was subsequently assessed using a Bradford Assay kit (Beyotime Institute of Biotechnology).…”

Section: Detection Of Apoptosismentioning

confidence: 99%

“…According to a prediction by the WHO, the number of patients with PC will have increased to 1.7 million by 2030 (4). Epidemiological studies have reported that the morbidity rate of PC is dependent on geography and ethnicity, and is more prevalent in developed countries (5,6).…”

Section: Introductionmentioning

confidence: 99%

Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1

Gao

Qiang

et al. 2017

Oncology Letters

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Abstract. Cucurbitacin E is an important member of the cucurbitacin family and exhibits inhibitory effects in various types of cancer. Cucurbitacin is a potential antineoplastic drug; however, its anticancer effect in human prostate cancer (PC) remains unknown. The aim of the present study was to determine whether the effect of cucurbitacin E on the cell viability and apoptosis of the human PC cell line, LNCaP, was mediated by cofilin-1-and mammalian target of rapamycin (mTOR). The results of the present study demonstrated that cucurbitacin E significantly exhibited cytotoxicity, suppressed cell viability (P<0.0001) and induced apoptosis (P=0.0082) in LNCaP cells. In addition, it was demonstrated that treatment with cucurbitacin E significantly induced cofilin-1 (P=0.0031), p-mTOR (P=0.0022), AMP-activated protein kinase (AMPK; P=0.0048), cellular tumor antigen p53 (p53; P=0.0018) and caspase-9 (P=0.0026) protein expression in LNCaP cells, suggesting that cucurbitacin E exerts its effects on LNCaP cells through cofilin-1, mTOR, AMPK, p53 and caspase-9 signaling. These results suggested that cucurbitacin E maybe used as a therapeutic agent in the treatment of human PC.

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“…Habl and colleagues published an HF schedule using either carbon ions or protons resulting in comparable acute toxicities [84]. Long-term outcome data on these treatments are not yet available.…”

Section: New Techniques: Proton Therapy Carbon Ionmentioning

confidence: 99%

Prostate Cancer Radiation Therapy: What Do Clinicians Have to Know?

Vanneste

Limbergen

Lin

et al. 2016

BioMed Research International

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Radiotherapy (RT) for prostate cancer (PC) has steadily evolved over the last decades, with improving biochemical disease-free survival. Recently population based research also revealed an association between overall survival and doses ≥ 75.6 Gray (Gy) in men with intermediate- and high-risk PC. Examples of improved RT techniques are image-guided RT, intensity-modulated RT, volumetric modulated arc therapy, and stereotactic ablative body RT, which could facilitate further dose escalation. Brachytherapy is an internal form of RT that also developed substantially. New devices such as rectum spacers and balloons have been developed to spare rectal structures. Newer techniques like protons and carbon ions have the intrinsic characteristics maximising the dose on the tumour while minimising the effect on the surrounding healthy tissue, but clinical data are needed for confirmation in randomised phase III trials. Furthermore, it provides an overview of an important discussion issue in PC treatment between urologists and radiation oncologists: the comparison between radical prostatectomy and RT. Current literature reveals that all possible treatment modalities have the same cure rate, but a different toxicity pattern. We recommend proposing the possible different treatment modalities with their own advantages and side-effects to the individual patient. Clinicians and patients should make treatment decisions together (shared decision-making) while using patient decision aids.

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Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase II Study—The IPI Trial

Cited by 53 publications

References 24 publications

Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams

Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams

Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1

Prostate Cancer Radiation Therapy: What Do Clinicians Have to Know?

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