Acute toxicity and genotoxicity of fermented traditional medicine oyaksungi-san

Park, Hwayong; Hwang, Youn–Hwan; Yeul, Jin

doi:10.1016/j.imr.2017.03.006

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…For instance, in the Yao Xing Lun of the Tang Dynasty (618–907 AD), it was documented that ‘Liu Shen Qu’ and ‘Jian Shen Qu’ were made from fermented Chinese herbs. Probiotic fermented Chinese medicine has the advantage of releasing more active chemicals, lowering hazardous side effects, and being easier to absorb by the body, thereby strengthening the prebiotic properties for metabolic syndrome 16,17 . For instance, unfermented and probiotic fermented noni fruit 18 and ginseng 19 have been examined, with results indicating that fermented noni fruit and ginseng are more beneficial in ALD treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Probiotic fermented Chinese medicine has the advantage of releasing more active chemicals, lowering hazardous side effects, and being easier to absorb by the body, thereby strengthening the prebiotic properties for metabolic syndrome. 16,17 For instance, unfermented and probiotic fermented noni fruit 18 and ginseng 19 have been examined, with results indicating that fermented noni fruit and ginseng are more beneficial in ALD treatment. Lactic acid bacteria are frequently used in probiotic fermentations.…”

Section: Introductionmentioning

confidence: 99%

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Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Zhao

Peng

et al. 2022

J Sci Food Agric

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BACKGROUND: Pueraria lobata (Willd.) Ohwi (PL) has been used in China to detoxify alcohol and protect the liver for millennia, though its mechanism of liver protection has not been elucidated. However, fermentation is considered to be one of the effective ways to enhance the efficacy of traditional Chinese medicine. The aim of this study was to investigate the hepatoprotective mechanism of probiotic-fermented PL (FPL). Sprague Dawley rats were administered with FPL followed by gavage of alcohol for seven consecutive days; following that, liver injury levels were evaluated in rats.RESULTS: FPL ameliorated lipid accumulation and inflammation levels in rats. Meanwhile, the levels of ethanol dehydrogenase, acetaldehyde dehydrogenase, and cytochrome P4502E1 were elevated by FPL treatment. It was observed that the levels of catalase, superoxide dismutase, and glutathione peroxidase were elevated, and the expression of nuclear transcriptional factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 genes and proteins were increased by FPL treatment, demonstrating that the Nrf2-mediated signal pathway was activated. Furthermore, FPL restored the composition of the gut microbiota with an increase in the abundances of Firmicutes and Lactobacillus and a decrease in the abundances of Bacteroidota and Akkermansia. Additionally, a strong correlation was found between the gut microbiota and the antioxidant parameters. CONCLUSION:The results indicate that FPL possesses an excellent protective effect in alcoholic liver injury. Our findings are beneficial to the development of hepatoprotective nutraceuticals for alcoholics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Zhao

Peng

et al. 2022

J Sci Food Agric

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Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Ma,

Liu,

Wang

et al. 2023

Chemistry & Biodiversity

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Cnidium officinale Makino (COM), a perennial herbaceous plant in the Apiaceous family, widely distribute in Eastern Asia and Asia‐Temperate. It has a long history application as a traditional medicine for invigorating the blood and removing blood stasis, and also has been employed to diet, pesticide, herbal bathing materials, the cosmetic and skin care industry. However, there has been no associated review of literature in the past half a century (1967–2023). By searching the international authoritative databases and collecting 229 literatures closely related to COM, herewith a comprehensive and systematic review was conducted. The phytology includes plant distribution and botanical characteristics. The phytochemistry covers 8 major categories, 208 compounds in total, and the quantitative determination of 14 monomer compounds, total polyphenols and total flavonoids. The clinical trial in pregnant women and toxic experiments in mice, the pharmacology of 7 aspects and 82 frequently used prescriptions are summarized. It is expected that this paper will provide forward‐looking scientific thinking and literature support for the further modern research, development and utilization of COM.

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Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review

Liao

Zhou

et al. 2022

Adv Neurodev Disord

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Acute toxicity and genotoxicity of fermented traditional medicine oyaksungi-san

Abstract: Graphical abstract

Cited by 4 publications

References 29 publications

Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review

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