Acute‐to‐chronic species sensitivity distribution extrapolation

Duboudin, Cédric; Ciffroy, Philippe; Magaud, Hélène

doi:10.1002/etc.5620230723

Cited by 67 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SSD concept is sometimes used to provide a probabilistic ecological risk assessment and to estimate chemical concentrations protective of most species in the environment (Caldwell et al 2008;Duboudin et al 2004;Dyer et al 2008;Giddings et al 2009;Grist et al 2006;Jagoe and Newman 1997;Roessink et al 2006;Simpson 2005). A point estimate known as the HC x (hazardous concentration for x% of species) is calculated.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of pentachlorophenol to native aquatic species in the Yangtze River

Jin

Zha

et al. 2011

Environ Sci Pollut Res

View full text Add to dashboard Cite

Introduction While the literature is replete with studies of the toxic potency of pentachlorophenol (PCP), site-specific criteria for native aquatic species that can be used in ecological risk assessments has been lacking and application of toxicity information for non-native species is controversial. Materials and methods In the present study, acute and chronic toxicities of PCP to six aquatic species native to the Yangtze River were determined. The HC 5 and HC 50 (hazardous concentration for 5% and 50% of species) were derived from dose-response curves for these native aquatic species and were then compared with those derived for non-native species. Results The acute toxicity values for the native species ranged from 8.8×10−2 mg l −1 (Plagiognathops microlepis) to 1.1 mg l −1 (Soirodela polyrhiza), while chronic toxicity values based on no observed effect concentrations (NOECs) ranged from 0.01 mg l −1 (Macrobrachium superbum) to 0.25 mg l −1 (Soirodela polyrhiza). Native aquatic benthos was more sensitive to acute PCP exposure than non-native species. There was no significant difference in NOECs derived from native fish species and those based on nonnative fish species. The median acute HC 5 and HC 50 derived from the toxicity data of native taxa were both less than those derived from non-native taxa. There was no significant difference between chronic HC 5 s derived from the two sets of taxa. However, the median chronic HC 50 derived from native taxa was less than that derived from non-native taxa.Conclusion The study upon which we report here provides site-specific toxicity information developed for native species which can be used for the protection of local aquatic life from a common contaminant, PCP.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxicity of pentachlorophenol to native aquatic species in the Yangtze River

Jin

Zha

et al. 2011

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…Duboudin et al [8] developed relationships to transform a data sample representative of the acute toxicity of a substance on the vertebrates and invertebrates into a data sample predicted to be representative of the chronic toxicity of the same substance (ACT method). This method was tested and validated on 11 substances for which a sufficient number of chronic and acute data are available.…”

Section: Resultsmentioning

confidence: 99%

“…Duboudin et al [8] compared, for several substances, SSDs constructed from acute toxicity data with SSDs constructed from chronic data, and more specifically the mean and standard statistics of the log-normal distributions associated with both of them. They developed thus an Acute-to-Chronic Transformation method allowing one to incorporate acute data in the construction of chronic SSDs.…”

Section: Methodsmentioning

confidence: 99%

“…The ACT approach developed by Duboudin et al [8] thus has two main advantages over the assessment factors method: first, rather than providing a single value, it gives a distribution of vertebrate and/or invertebrate data, associated with a confidence envelope for acute-to-chronic transformation. This or these distribution(s) of predicted chronic data can be compared with real available chronic values if existent.…”

Section: Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

Methods for calculating PNECs using species sensitivity distribution (SSD) with various hypothesis on the way to handle ecotoxicity data

Ciffroy¹

2007

Environmental Health Risk IV

View full text Add to dashboard Cite

Species sensitivity distribution (SSD) methodology is currently used to determine the Predicted No Effect Concentration (PNEC) of a substance, considering chronic ecotoxicological tests on three taxonomic groups: algae, invertebrates and vertebrates (aquatic environment). However, SSD methodology raises some practical questions due to the multiple possibilities of handling the available data. In particular the following points are often discussed: (1) how to take into account the intra-species variation; (2) how to handle heterogeneous repartition of available data among the taxonomic groups; (3) could we use the information contained in acute data, and how, in the construction of SSDs; (4) when only a limited number of data is available, how is it possible to build relevant SSDs. Different approaches have been tested in answer to each of these questions: For questions (1) and (2): different methods were compared, each of them being characterized by a different way of taking into account intra-species variation and proportions of taxonomic groups (vertebrates, invertebrates and algae), as well as by the actual method of calculation of the HC5 (Hazardous Concentration) and its confidence interval. These different methods were compared for 15 substances using NOEC data available in the literature and the uncertainty associated to the data treatment was quantified. For question (3): an "Acute-to-Chronic Transformation" (ACT) function was derived and a methodology for the incorporation of acute data in the construction of SSDs was tested. This ACT method was tested on 11 substances: for each substance, the actual chronic SSD was compared to the predicted SSD derived from the incorporation of transformed acute data. For question (4): Bayesian methods were tested to build SSDs from limited datasets and the relevance of such methods was discussed. Various approaches are suggested here in answer to each of these three questions. They have been combined in a comprehensive overview to define alternative strategies according to the availability of ecotoxicological data.

show abstract

“…For example, Duboudin et al [8,20] calculated the chronic and acute SSDs of several substances for which sufficient data were available. If the standard deviation is relatively homogeneous among substances, prior information about the expected variance of the SSD can be defined for a new substance.…”

Section: Introductionmentioning

confidence: 99%

Estimating hazardous concentrations by an informative Bayesian approach

Ciffroy

Keller

Pasanisi

2013

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Abstract-The species sensitivity distribution (SSD) approach is recommended for assessing chemical risk. In practice, however, it can be used only for the few substances for which large-scale ecotoxicological results are available. Indeed, the statistical frequentist approaches used for building SSDs and for deriving hazardous concentrations (HC5) inherently require extensive data to guarantee goodness-of-fit. An alternative Bayesian approach to estimating HC5 from small data sets was developed. In contrast to the noninformative Bayesian approaches that have been tested to date, the authors' method used informative priors related to the expected species sensitivity variance. This method was tested on actual ecotoxicological data for 21 well-informed substances. A cross-validation compared the HC5 values calculated using frequentist approaches with the results of our Bayesian approach, using both complete and truncated data samples. The authors' informative Bayesian approach was compared with noninformative Bayesian methods published in the past, including those incorporating loss functions. The authors found that even for the truncated sample the HC5 values derived from the informative Bayesian approach were generally close to those obtained using the frequentist approach, which requires more data. In addition, the probability of overestimating an HC5 is rather limited. More robust HC5 estimates can be practically obtained from additional data without impairing regulatory protection levels, which will encourage collecting new ecotoxicological data. In conclusion, the Bayesian informative approach was shown to be relatively robust and could be a good surrogate approach for deriving HC5 values from small data sets. Environ. Toxicol. Chem. 2013;32:602-611. # 2012 SETAC

show abstract

Acute‐to‐chronic species sensitivity distribution extrapolation

Cited by 67 publications

References 18 publications

Toxicity of pentachlorophenol to native aquatic species in the Yangtze River

Toxicity of pentachlorophenol to native aquatic species in the Yangtze River

Methods for calculating PNECs using species sensitivity distribution (SSD) with various hypothesis on the way to handle ecotoxicity data

Estimating hazardous concentrations by an informative Bayesian approach

Contact Info

Product

Resources

About