Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Fujii, H.; Nishioka, Hiroshi; Wakame, Koji; Magnuson, Bernadene A.; Roberts, Ashley

doi:10.1016/j.fct.2008.06.005

Cited by 57 publications

(55 citation statements)

References 32 publications

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“…Oligonol is commercially available (Amino Up Chemical Co., Ltd., Sapporo, Japan). The safety of oligonol as a food or dietary supplement and as a pharmaceutical additive has already been confirmed (21,22).…”

Section: Oligonolmentioning

confidence: 99%

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice

Park

Noh

Fujii

et al. 2015

DD&T

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Section: Oligonolmentioning

confidence: 99%

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice

Park

Noh

Fujii

et al. 2015

DD&T

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“…Polyphenols are a group of chemical substances in human diets (8). The major sources of dietary polyphenol are fruits, vegetables and green tea (9,10).…”

Section: Introductionmentioning

confidence: 99%

Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: Roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways

Chen

Lin

et al. 2011

Oncol Rep

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Abstract. Epigallocatechin-3-gallate (EGCG), a polyphenol constituent present in green tea, has been shown to inhibit the growth of cancer cells in vitro and in vivo. However, studies regarding human bladder carcinoma cells are limited and not well investigated. Hence, our study focused on the evaluation of EGCG-triggered apoptosis in TSGH-8301 human urinary bladder carcinoma cells in vivo and in vitro as well as its related molecular mechanisms. In an in vivo study, EGCG inhibited xenograft tumor size of TSGH-8301 cells in a nude mouse model. Based on an in vitro study, EGCG resulted in morphological changes and increased growth inhibition in a dose-and time-dependent manner in TSGH-8301 cells. Furthermore, sub-G1 populations were shown and caspase-9 and -3 activities were stimulated in EGCG-treated TSGH-8301 cells. Moreover, a caspase-9 inhibitor (Z-LEHD-FMK) and a caspase-3 inhibitor (Z-DEVD-FMK) were able to reduce EGCG-stimulated caspase-9 and -3 activities, respectively. Loss of mitochondrial membrane potential (∆Ψm) resulted in an increase of protein levels of cytochrome c, Apaf-1, caspase-9 and -3 in TSGH-8301 cells following exposure to EGCG. Proteomic analysis revealed that EGCG affected the expression levels of various proteins, including HSP27, porin, tropomyosin 3 isoform 2, prohibitin and keratin 5, 14, 17 in TSGH-8301 cells. EGCG also suppressed AKT kinase activity and protein levels and also altered the expression levels of Bcl-2 family-related proteins such as Bcl-2, Bax, BAD and p-BAD. Based on the above findings, this study suggests that EGCGprovoked apoptotic death in TSGH-8301 cells is mediated through targeting AKT and HSP27 and modulating p-BAD, leading to activation of the intrinsic apoptotic pathway.

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“…Such oligomerized polyphenol compounds are considered to be easily absorbed and have higher bioavailability than polyphenol polymers abundant in raw fruits and plants [21]. Oligonol has been reported to be safe enough for use as a dietary supplement [19] [22], while exhibiting strong antioxidant capacity [21]. The safety of Oligonol was established in studies evaluating acute and subchronic administration, as well as its genotoxicity [19].…”

Section: Introductionmentioning

confidence: 99%

“…Oligonol is a commercially available, manufactured dietary ingredient containing oligomerized polyphenols, namely monomeric and oligomeric proanthocyanidins, derived from lychee and other fruits [19] by a fragmentation of proanthocyanidine polymers from crude fruit extracts [20]. Such oligomerized polyphenol compounds are considered to be easily absorbed and have higher bioavailability than polyphenol polymers abundant in raw fruits and plants [21].…”

Section: Introductionmentioning

confidence: 99%

Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

Kisugi¹,

Nasui²,

Wakame³

et al. 2014

ABC

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Oligonol is a lychee fruit-derived functional food that contains oligomerized polyphenol compounds. Oligonol exhibits a number of beneficial biological effects, primarily due to its antioxidant activity. Retinitis pigmentosa (RP) is an inherited chronic degenerative disease affecting retinal photoreceptor cells. There is currently no effective therapy capable of stopping or reversing the progression of the disease. In RP, apoptosis of photoreceptor cells resulting from oxidative damage is considered to be the final common pathway. In this report, we present an evaluation of the suppressive activity of Oligonol against N-methyl-N-nitrosourea (

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Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Cited by 57 publications

References 32 publications

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: Roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways

Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

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Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Cited by 57 publications

References 32 publications

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: Roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways

Suppression of &lt;i&gt;N&lt;/i&gt;-Methyl-&lt;i&gt;N&lt;/i&gt;-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

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Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation