Acute skin toxicity associated with proton beam therapy in spine and brain patients

Moskvin, V.; Lasley, Foster D.; Ray, Geoffrey L.; Gautam, Archana; Cheng, Chee-Wai; Das, Indra J.; Buchsbaum, Jeffrey C.

doi:10.1007/s13566-013-0128-1

Cited by 8 publications

(10 citation statements)

References 25 publications

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“…A low number of smokers (13,8%) may explain no correlation to skin reactions wich is not in line with earlier studies [30] , [31] , [32] . Age [30] , [31] or gender [8] did not seem to play a role in skin reactions which is in agreement with earlier studies.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, at the end of treatment, the clinicians reported the presence of skin reactions (any grade) for 71% of the patients, while only 53% of the patients reported skin reactions (any grade) at the same time point. This was an unexpected result because the values were lower than one earlier study that showed 86% of the patients reported experiencing some grade of acute skin toxicity [8] , which may be explained by the newer PBS technique compared to the passive scatter technique.…”

Section: Discussioncontrasting

confidence: 65%

“…Skin reactions may cause physical and psychosocial discomfort, resulting in a negative impact on their quality of life [7] . In severe cases, radiation-induced wounds may require a reduced radiation dose [8] . Severe acute skin reactions are also associated with a higher risk of chronic radiation-induced skin changes (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Prevalence of skin reactions has been reported to as high as 86% among patients with brain tumours [8] and 89% among all patients that received PBT [11] . In these studies, most of the patients had grade 1 (faint erythema) skin reactions, and very few had grade 3 (desquamation) or 4 (ulceration).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Möllerberg¹,

Langegård

Johansson

et al. 2021

Technical Innovations & Patient Support in Radiation Oncolo

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Highlights Radiotherapy is used in the treatment for primary brain tumours. Radiotherapy causes acute and late toxicities where skin reactions are most common. The potential for misreporting of toxicity in specific cases may be significant. Oncologist-reported and patient-reported outcomes of skin reactions are crucial. A combination of PROs and oncologists’ assessments is most accurate.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Möllerberg¹,

Langegård

Johansson

et al. 2021

Technical Innovations & Patient Support in Radiation Oncolo

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“…The influence of energy on the severity of skin toxicity suggests the presence of radiobiological mechanisms specific to proton beam interaction with the epidermis and secondary particle generation. In general, paediatric patients have a long life expectancy and it is therefore important to examine more closely the skin reaction mechanism in proton therapy [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Dosimetric Comparison and Potential for Improved Clinical Outcomes of Paediatric CNS Patients Treated with Protons or IMRT

Armoogum

Thorp

2015

Cancers

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Background: We compare clinical outcomes of paediatric patients with CNS tumours treated with protons or IMRT. CNS tumours form the second most common group of cancers in children. Radiotherapy plays a major role in the treatment of many of these patients but also contributes to late side effects in long term survivors. Radiation dose inevitably deposited in healthy tissues outside the clinical target has been linked to detrimental late effects such as neurocognitive, behavioural and vascular effects in addition to endocrine abnormalities and second tumours. Methods: A literature search was performed using keywords: protons, IMRT, CNS and paediatric. Of 189 papers retrieved, 10 were deemed relevant based on title and abstract screening. All papers directly compared outcomes from protons with photons, five papers included medulloblastoma, four papers each included craniopharyngioma and low grade gliomas and three papers included ependymoma. Results: This review found that while proton beam therapy offered similar clinical target coverage, there was a demonstrable reduction in integral dose to normal structures. Conclusions: This in turn suggests the potential for superior long term outcomes for paediatric patients with CNS tumours both in terms of radiogenic second cancers and out-of-field adverse effects.

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Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers

Leroy

Benahmed

Hulstaert

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

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Acute skin toxicity associated with proton beam therapy in spine and brain patients

Cited by 8 publications

References 25 publications

Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Dosimetric Comparison and Potential for Improved Clinical Outcomes of Paediatric CNS Patients Treated with Protons or IMRT

Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers

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