Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Möllerberg, Marie-Louise; Langegård, Ulrica; Johansson, Birgitta; Ohlsson‐Nevo, Emma; Fransson, Per; Ahlberg, Karin; Witt-Nyström, Petra; Sjövall, Katarina

doi:10.1016/j.tipsro.2021.05.001

Cited by 6 publications

(4 citation statements)

References 38 publications

(67 reference statements)

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“… 4 , 5 However, the disease itself and the adverse effects of radiotherapy make skin reactions a common adverse effect after radiotherapy in NPC patients. 17 It has been reported that most NPC patients choose to give up treatment due to their inability to tolerate the pain of complications during radiotherapy, thus affecting the therapeutic effect and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy

Wang,

Liu,

et al. 2024

Pak J Med Sci

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Objective: To find out the effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy. Methods: This was a retrospective study. Sixty six patients with nasopharyngeal carcinoma who received radiotherapy in the Affiliated Hospital of Hebei University from March 2021 to March 2022 were included and randomly divided into the observation group and the control group, with 33 cases in each group. Patients in the control group were given conventional care measures, while those in the observation group were given psychological support intervention on top of conventional care measures. The nursing effects between the two groups were compared. Results: After the intervention, the psychological resilience score of the observation group was significantly higher than that of the control group, with a statistically significant difference (P<0.05). The psychological resilience scores after the intervention were significantly higher in the observation group than before the intervention, and those in the control group were higher than before the intervention, with a statistically significant difference(P<0.05). The overall health score of quality of life in the observation group was significantly higher than that in the control group after the intervention, with a statistically significant difference(P<0.05). Moreover, the skin reaction in the observation group after radiotherapy was significantly better than that of the control group (P<0.01). Conclusion: Psychological support intervention is an effective means to treat patients with nasopharyngeal carcinoma, which results in various benefits such as improving patients’ mental resilience and quality of life and reducing the incidence of adverse reactions after radiotherapy. doi: https://doi.org/10.12669/pjms.40.7.7875 How to cite this: Wang C, Liu X, Li Y, Liu D, Yang L, Wang Y. Effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.7875 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy

Wang,

Liu,

et al. 2024

Pak J Med Sci

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“…Proton therapy is a painless treatment; the patient can return home and perform daily activities. However, the proton beams promote unavoidable sore, reddened skin [38,39] (called erythema/flushing), hair loss and low body energy.…”

Section: External Beam Radiation Therapymentioning

confidence: 99%

Innate Immune System in the Context of Radiation Therapy for Cancer

Boopathi

Den

Thangavel

2023

Cancers

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Radiation therapy (RT) remains an integral component of modern oncology care, with most cancer patients receiving radiation as a part of their treatment plan. The main goal of ionizing RT is to control the local tumor burden by inducing DNA damage and apoptosis within the tumor cells. The advancement in RT, including intensity-modulated RT (IMRT), stereotactic body RT (SBRT), image-guided RT, and proton therapy, have increased the efficacy of RT, equipping clinicians with techniques to ensure precise and safe administration of radiation doses to tumor cells. In this review, we present the technological advancement in various types of RT methods and highlight their clinical utility and associated limitations. This review provides insights into how RT modulates innate immune signaling and the key players involved in modulating innate immune responses, which have not been well documented earlier. Apoptosis of cancer cells following RT triggers immune systems that contribute to the eradication of tumors through innate and adoptive immunity. The innate immune system consists of various cell types, including macrophages, dendritic cells, and natural killer cells, which serve as key mediators of innate immunity in response to RT. This review will concentrate on the significance of the innate myeloid and lymphoid lineages in anti-tumorigenic processes triggered by RT. Furthermore, we will explore essential strategies to enhance RT efficacy. This review can serve as a platform for researchers to comprehend the clinical application and limitations of various RT methods and provides insights into how RT modulates innate immune signaling.

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“…A PhD thesis was defended in February 2020 [34]. To date, PCSG has published 8 studies [35][36][37][38][39][40], presented in Table 2. As a result, there is an increase in the number of research projects of PBT based on PROMs.…”

Section: Intermediate Outcomesmentioning

confidence: 99%

Evaluating patient reported outcomes and experiences in a novel proton beam clinic – challenges, activities, and outcomes of the ProtonCare project

et al. 2023

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Background The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based on patient reported data. Method A logic model framework was used to describe the process of development and implementation of a structured plan for evaluation of PBT for all diagnoses based on patient reported data. After the mission for the project was determined, meetings with networks and stakeholders were facilitated by PCSG to identify assumptions, resources, challenges, activities, outputs, outcomes, and outcome indicators. Result This paper presents the challenges and accomplishments PCSG made so far. We describe required resources, activities, and accomplished results. The long-term outcomes that were outlined as a result of the process are two; 1) Improved knowledge about health outcomes of patients that are considered for PBT and 2) The findings will serve as a base for clinical decisions when patients are referred for PBT. Conclusion Using the logical model framework proved useful in planning and managing the ProtonCare project. As a result, the work of PCSG has so far resulted in long-lasting outcomes that creates a base for future evaluation of patients’ perspective in radiotherapy treatment in general and in PBT especially. Our experiences can be useful for other research groups facing similar challenges. Continuing research on patients´ perspective is a central part in ongoing and future research. Collaboration, cooperation, and coordination between research groups/networks from different disciplines are a significant part of the work aiming to determine the more precise role of PBT in future treatment options.

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Evaluation of skin reactions during proton beam radiotherapy – Patient-reported versus clinician-reported

Cited by 6 publications

References 38 publications

Effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy

Effects of psychological support intervention on patients with nasopharyngeal carcinoma undergoing radiotherapy

Innate Immune System in the Context of Radiation Therapy for Cancer

Evaluating patient reported outcomes and experiences in a novel proton beam clinic – challenges, activities, and outcomes of the ProtonCare project

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