Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

Hestermann, Dietmar; Temel, Yasin; Blokland, Arjan; Lim, Lee Wei

doi:10.1016/j.bbr.2014.07.003

Cited by 22 publications

(17 citation statements)

References 61 publications

(75 reference statements)

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“…MA exposure did not cause any long-term changes in plasma corticosterone levels in either adolescent or adult mice. This finding replicates studies showing no immediate effects (Rud et al, 2016) or long-term effects (Buck et al, 2017) (Aisa, Tordera, Lasheras, Del Rio, & Ramirez, 2007;Hestermann, Temel, Blokland, & Lim, 2014), the dopamine, serotonin, and norepinephrine neurotransmitter systems also influence these behaviors (Carrasco & Van de Kar, 2003;Dunlop & Nemeroff, 2007;Owens & Nemeroff, 1994) and these neurotransmitter systems are altered by MA (Sulzer et al, 2005). Thus, the behavioral effects of MA in the adult mice may be due to MA's effects on these neurotransmitter systems.…”

Section: Ta B L E 1 Plasma Corticosterone Concentrationssupporting

confidence: 85%

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.

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Section: Ta B L E 1 Plasma Corticosterone Concentrationssupporting

confidence: 85%

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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“…This observation is strongly supported by our previous studies in which we found no significant difference in the center zone of the open-field after serotonergic drugs treatment (e.g. buspirone, escitalopram) in a low-anxiety condition as compared to the high-anxiety condition2529. Regardless, our findings provide evidence that TTC9A gene has an important role in modulating the anxiety-like behavior.…”

Section: Discussionsupporting

confidence: 91%

“…As serotonergic system is fundamentally important in anxiety disorders2425, we investigated if the changes in mRNA expression levels of TPH1, TPH2, and 5-HTT in the vmPFC and the DRN of TTC9A −/− mice would be the reason for increased anxiety-like behaviors.…”

Section: Resultsmentioning

confidence: 99%

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice

Lim

Shrestha

et al. 2016

Sci Rep

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Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A−/− mice model. A battery of tests on anxiety-related behaviors was conducted. Our results demonstrated that TTC9A−/− mice exhibited an increase in anxiety-like behaviors compared to the wild type TTC9A+/+ mice. This difference was abolished after ovariectomy, and administration of 17-β-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A−/− mice. Since serotonin is well-known to be the key neuromodulator involved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved in serotonin synthesis), and serotonin transporter (5-HTT) were measured in the ventromedial prefrontal cortex (vmPFC) and dorsal raphe nucleus (DRN). Interestingly, the heightened anxiety in TTC9A−/− mice under EB influence is consistent with a greater induction of TPH 2, and 5-HTT by EB in DRN that play key roles in emotion regulation. In conclusion, our data indicate that TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the DRN.

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“…For histological quantification, the counting for c-Fos immunoreactive (c-Fos-ir), BrdU and Dcx-positive cells ( Lim et al, 2008 ; Hestermann et al, 2014 ), and measurement of dendritic spine density ( Vyas et al, 2003 ) were performed using previously established methods with minor modifications. In brief, the c-Fos-ir cells per mm 2 (six sections per animals) was counted in the subiculum, dentate gyrus, CA1, and CA3 field of the hippocampus using image analysis program ‘Image J’ (version 1.47, NIH, USA).…”

Section: Methodsmentioning

confidence: 99%

Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats

Liu

Jain

Vyas

et al. 2015

eLife

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Memory dysfunction is a key symptom of age-related dementia. Although recent studies have suggested positive effects of electrical stimulation for memory enhancement, its potential targets remain largely unknown. In this study, we hypothesized that spatially targeted deep brain stimulation of ventromedial prefrontal cortex enhanced memory functions in a middle-aged rat model. Our results show that acute stimulation enhanced the short-, but not the long-term memory in the novel-object recognition task. Interestingly, after chronic high-frequency stimulation, both the short- and long-term memories were robustly improved in the novel-object recognition test and Morris water-maze spatial task compared to sham. Our results also demonstrated that chronic ventromedial prefrontal cortex high-frequency stimulation upregulated neurogenesis-associated genes along with enhanced hippocampal cell proliferation. Importantly, these memory behaviors were strongly correlated with the hippocampal neurogenesis. Overall, these findings suggest that chronic ventromedial prefrontal cortex high-frequency stimulation may serve as a novel effective therapeutic target for dementia-related disorders.DOI: http://dx.doi.org/10.7554/eLife.04803.001

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Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

Cited by 22 publications

References 61 publications

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice

Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats

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