Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats

Liu, Albert; Jain, Neeraj; Vyas, Ajai; Lim, Lee Wei

doi:10.7554/elife.04803

Cited by 64 publications

(113 citation statements)

References 86 publications

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“…In addition, emotional and cognitive symptoms such as depression and attention disorders were also reported in LIP‐treated rats, but not in KA . Moreover, in the present study, we used a long‐term memory test design instead of a short‐term memory test, which might also explain why our observation was partly inconsistent with previous reports.…”

Section: Discussioncontrasting

confidence: 64%

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

et al. 2018

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Our results indicated a trend of decreased connectivity in the hippocampal functional network, as well as spatial, object, and episodic memory impairment in the pilocarpine-induced TLE rat. Moreover, connections within the hippocampal network showed a relationship with spatial memory, and connections between the hippocampal network and regions in other networks revealed an association with both spatial and object memory.

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Section: Discussioncontrasting

confidence: 64%

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

et al. 2018

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“…Recent studies that have reported on the memory modulation effect after applying mPFC stimulation in animals (Liu, Jain, Vyas, & Lim, 2015) and humans (Berkers et al, 2017) partly support the feasibility of our suggestion. Recent studies that have reported on the memory modulation effect after applying mPFC stimulation in animals (Liu, Jain, Vyas, & Lim, 2015) and humans (Berkers et al, 2017) partly support the feasibility of our suggestion.…”

Section: Implications For Future Clinical Applicationssupporting

confidence: 81%

Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe

Jeong

Lee²,

Kim

et al. 2019

Human Brain Mapping

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How the brain supports normal episodic memory function without medial temporal lobe (MTL) structures has not been well characterized, which could provide clues for new therapeutic targets for people with MTL dysfunction‐related memory impairment. To characterize brain network supporting effective episodic memory function in the absence of unilateral MTL, we investigated the whole‐brain cortical interactions during functional magnetic resonance imaging memory encoding paradigms of words and figures in patients who showed a normal range of memory capacity following unilateral MTL resection and healthy controls (HC). Compared to the HC, the patients showed less activation in the left inferior frontal areas and right thalamus together with greater activation in the many cortical areas including the medial prefrontal cortex (mPFC). Task‐based functional connectivity (FC) analysis revealed that the mPFC showed stronger interactions with widespread brain areas in both patient groups, including the hippocampus contralateral to the resection. Moreover, the strength of the mPFC FC predicts the individual memory capacity of the patients. Our data suggest that hyperconnectivity of distributed brain areas, especially the mPFC, is a neural mechanism for memory function in the absence of one MTL.

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“…The object recognition test was performed as previously described with minor modifications53. The test consists of a habituation phase, acquisition phase, and finally the test phases for short-term memory (1 h after acquisition phase), and long-term memory (24 h after short-term memory test) functions.…”

Section: Methodsmentioning

confidence: 99%

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice

Lim

Shrestha

et al. 2016

Sci Rep

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Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A−/− mice model. A battery of tests on anxiety-related behaviors was conducted. Our results demonstrated that TTC9A−/− mice exhibited an increase in anxiety-like behaviors compared to the wild type TTC9A+/+ mice. This difference was abolished after ovariectomy, and administration of 17-β-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A−/− mice. Since serotonin is well-known to be the key neuromodulator involved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved in serotonin synthesis), and serotonin transporter (5-HTT) were measured in the ventromedial prefrontal cortex (vmPFC) and dorsal raphe nucleus (DRN). Interestingly, the heightened anxiety in TTC9A−/− mice under EB influence is consistent with a greater induction of TPH 2, and 5-HTT by EB in DRN that play key roles in emotion regulation. In conclusion, our data indicate that TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the DRN.

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Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats

Cited by 64 publications

References 86 publications

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice

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