Acute Rhinosinusitis:  Actual Approaches  to Diagnosis  and Treatment

Кочетков, П. А.; Фатьянова, Е. И.

doi:10.21518/2079-701x-2017-8-130-136

Cited by 6 publications

(4 citation statements)

References 7 publications

(24 reference statements)

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“…Clinical guidelines do not contain criteria for assessing severity of the patient's state and differentiated choice of therapy scheme (Wong and Irwin 2013;Kochetkov and Fatyanova 2017). Unfortunately, in severe and extremely severe conditions, detoxification measures may be ineffective and insufficient.…”

Section: Resultsmentioning

confidence: 99%

Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

Karpushkina¹,

Zhdanova²,

Batisheva³

2022

RRP

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Introduction: Acute poisoning is often observed in children and can have serious consequences since it is characterized by rapid development of symptoms and obvious disfunction of vital organs. Materials and methods: Retrospective analysis of the case histories of the children with acute poisoning admitted to Voronezh Regional Children’s Clinical Hospital No. 1 in 2016–2019 was carried out. Anamnesis, clinical and laboratory studies and effective treatment criteria were entered into electronic spreadsheets and served as the basis for a database on children’s poisoning. Results and discussion: Analysis of 183 case histories of children with intoxication aged 4 months to 17 years old was performed. Distribution per age showed bimodal peaks at 1–2 years and 13–14 years. Poisoning was accidental in 96.2% of the cases, and 3.8% of the adolescents reported suicide cases. In the group of young children, acute drug poisoning is more frequent in girls (P < 0.05). In the older groups, there is no gender difference in frequency of poisoning cases. Early call for medical help is typical for the adolescent age group. Correlation between time of help-seeking and children’s age is statistically significant (correlation coefficient r = 0.38, P < 0.05). Conclusion: Study of poisoning issue in children will allow to carry out targeted preventive measures to reduce the number of poisoning cases, prevent their consequences and to determine the most rational modus operandi for medical personnel for effective and safe pharmacotherapy. Graphical abstract In pediatric practice, intoxication by poisons and drugs is among the most common reasons for seeking medical help and hospitalization in intensive care units. It is important to study and record dynamics, structure and frequency of acute poisoning with subsequent development of prevention and treatment methods.

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Section: Resultsmentioning

confidence: 99%

Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

Karpushkina¹,

Zhdanova²,

Batisheva³

2022

RRP

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“…This leads to a significant reduction of sympathetic impulse flow and further to lack of energy and enthusiasm, drowsiness, development of bradycardia, and hypotension. With an increase in intoxication, the symptoms intensify up to coma (Mahieu et al 1993;Vitezić et al 1994;Malakhov et al 2015;Kochetkov and Fatyanova 2017).…”

Section: Anatomical and Physiological Specific Features Of The Nose Structure In Childrenmentioning

confidence: 99%

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

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Introduction: Acute poisoning by nasal decongestants is an important issue in pediatrics due to physiological and anatomical characteristics of the child’s body and pharmacokinetics of drugs in early childhood. Epidemiology: The number of poisonings by this group of drugs ranged from 4% to 39% during the period from 2000 to 2018. All the studies reported that the most severe degree of intoxication was observed in children aged 1–3 years. Mechanism of action of nasal decongestants: The peculiarity of selective alpha2-adrenergic agonists is that when taken orally, misused or overdosed, they lose their selectivity for the target receptor. As a result, the drug causes acute poisoning and most often this effect occurs in children and adolescents. Clinical features and diagnostic criteria: Clinical signs of acute poisoning can appear both as a result of an overdose of the nasal decongestants and due to a therapeutic use of the drug according to the instruction. The symptoms are manifested by hypothermia, skin pallor, bradycardia, arterial hypotension, profuse sweating, and acrocyanosis. Imidazoline receptors and new opportunities: It is assumed that toxic effect of topical decongestants occurs not only by activation of alpha2-adrenergic receptors, but also through their influence on the selective imidazoline receptors. Based on the structure of these drugs, it is assumed that imidazoline receptors are the primary binding site for these drugs. Conclusion: Understanding the described mechanisms of alpha2-adrenergic agonist action and peculiarities of the child’s symptoms in acute poisoning is necessary for the timely diagnosis and selection of the correct treatment strategy.

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“…В хронизации заболевания ведущую роль играют анатомические особенности: искривление перегородки носа, булла средней носовой раковины, инфраорбитальная клетка, аномалии строения крючковидного отростка, дополнительное соустье верхнечелюстной пазухи и др. [28,29].…”

Section: аналитический обзорunclassified

“…Микробиологическое исследование мазков из среднего носового хода или пунктата воспаленной пазухи в обычных случаях при ОРС не является необходимым -этот метод применяется, как правило, с научной целью [4]. Оптимальным является проведение эндоскопического исследования полости носа и носоглотки, позволяющего оценить состояние внутриносовых структур и выявить вовлечение в патологический процесс ближайших анатомических образований [24,28].…”

Section: аналитический обзорunclassified

Topical therapy in the treatment of patients with acute rhinosinusitis in adults

Старостина¹,

Sivokhin²

2021

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Acute rhinosinusitis is one of the most common diseases in the world, characterized by acute inflammatory processes in the nasal cavity and paranasal sinuses, lasting less than 4 weeks. According to statistics, in Russia, this disease is recorded in 6–15% of the population annually, in European countries in every seventh person, while there is a tendency to an increase in the incidence. Acute viral rhinosinusitis has the highest incidence among all rhinosinusitis and occurs in most patients in a mild form, however, untimely treatment of inflammation of the nasal mucosa can lead to obstruction of the natural anastomoses, impaired physiological ventilation and drainage of the paranasal sinuses, stagnation of secretions with further development acute bacterial rhinosinusitis. The overuse of local vasoconstrictor drugs (intranasal decongestants) leads to the development of drug-induced rhinitis, long-term imbalance of autonomic innervation of the nasal mucosa and edema, called "rebound syndrome". In the article we consider the issues of etiology, pathogenesis, features of the course of rhinosinusitis. The principles of differential diagnosis of viral and bacterial rhinosinusitis are stated, taking into account the latest recommendations and research in this area. The features of the use of the most frequently used topical preparations in acute rhinosinusitis in the practice of an ENT doctor have been analyzed.

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Acute Rhinosinusitis: Actual Approaches to Diagnosis and Treatment

Cited by 6 publications

References 7 publications

Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

Pathogenetic features of acute naphazoline poisoning in children

Topical therapy in the treatment of patients with acute rhinosinusitis in adults

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