Acute Retinal Pigment Epitheliitus

Krill, Alex E.; Deutman, August F.

doi:10.1016/0002-9394(72)90535-1

Cited by 107 publications

(65 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most patients with APMPPE reportedly experience rap id loss of vision [1][2][3][4][5][6][7][8]. Our patient, however, had good vi sual acuity.…”

Section: Case Reportcontrasting

confidence: 41%

“…The findings in our patient could be differentiated from those in multiple evanescent white dot syndrome [6,7], in which white spots at the level of the retinal pigment epi thelium disappear within 3-10 weeks and early punctate hy perfluorescence is present on fluorescein angiography, acute retinal pigment epitheliitis [8], in which spots appear as dark dots surrounded by a halo of depigmentation, serpi ginous or geographic choroiditis [9], which usually begins in the peripapillary area and spreads centrifugally, diffuse unilateral subacute ncuroretinitis [10], in which the electroretinogram in the affected eye is usually reduced, and vitiliginous chorioretinitis (bird-shot retinochoroidopathy) [11,12], which appears in older patients and is usually bilateral.…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Unilateral Acute Posterior Multifocal Placoid Pigment Epitheliopathy

1996

View full text Add to dashboard Cite

A 24-year-old woman complained of paracentral scotomas in her left eye. Her visual acuity was good bilaterally. Multifocal, creamy, yellow-white lesions were seen at the level of the pigment epithelium and choroid in the left fundus. Fluorescein angiography showed blockage at the early phase and hyperfluorescence at the late phase in the left eye. The right fundus remained normal during the follow-up period of 1 year. We believe that unilateral acute posterior multifocal placoid pigment epitheliopathy, as found in our patient, may be uncommon.

show abstract

“…Most patients with APMPPE reportedly experience rap id loss of vision [1][2][3][4][5][6][7][8]. Our patient, however, had good vi sual acuity.…”

Section: Case Reportcontrasting

confidence: 41%

Section: Case Reportmentioning

confidence: 99%

Unilateral Acute Posterior Multifocal Placoid Pigment Epitheliopathy

1996

View full text Add to dashboard Cite

show abstract

“…Acute retinal pigment epithelitis (ARPE), also known as Krill's disease, is characterized by an acute and severe loss of vision in young, healthy adults with a self-limiting course and affecting both males and females equally [1]. It is thought to represent areas of RPE inflammation with breakdown of the pigment epithelial barrier and subsequent leakage of serous fluid.…”

Section: Case Reportmentioning

confidence: 99%

“…FA and ICG revealed some patched areas of irregular hypofluorescence surrounding the old spots due to filling defect of choroidal vessels and characterized by late staining of dye on FA and no leakage (Figures 2A and 2B). Hypofluorescent areas were shown on both intermediate and late ICG phases with reducing size compared to the acute phases in the same areas.Acute retinal pigment epithelitis (ARPE), also known as Krill's disease, is characterized by an acute and severe loss of vision in young, healthy adults with a self-limiting course and affecting both males and females equally [1]. It is thought to represent areas of RPE inflammation with breakdown of the pigment epithelial barrier and subsequent leakage of serous fluid.…”

mentioning

confidence: 99%

Retinal epithelitis as ocular side effects of oral biphosphonates

Giudice¹,

Crepaldi²,

Catania³

et al. 2017

Clin Case Rep Rev

View full text Add to dashboard Cite

Alendronate is a new bisphosphonate, primarily used for the treatment of osteoporosis and several other bone diseases. Herein we report a case of a patient showing an acute retinal pigment epithelitis (ARPE) following oral administration of alendronate due to osteoprosis. A 50-year old female referred to our observation complaining visual blurring and metamorphopsia in her left eye. She did not report ocular impairment in the past. Her clinical history was unremarkable for any systemic disease except she had being suffering for osteoporis for 6 months treated by means administration of oral alendronate. Her visual acuity was 20/40 OS and 20/20 OD respectively. There was no vitritis or anterior uveitis. At fundus examination subtle clumps of hyperpigmentation surrounded by a paler halo of hypopigmentation around macula of the retinal pigment epithelium (RPE) were shown in OS. In the right eye ophthalmoscopy showed some cluster of irregular pigmentation above the fovea associated with slight hypopigmentation surrounding the clump. Fluorescein angiography (FA) revealed an irregular patchy area of early hypofluorescence, surrounded by hyperfluorescence, while fading in the late phase ( Figure 1A). Earlyphase and midphase indocyanine green angiography (ICG) showed a patchy macular hypofluorescence in both eyes (Figures 1B and 1C). Similar disseminated spots of hypofluorescence were shown at the periphery nasally to the optic disk; hypofluorescent halo with a petaloid like appearance of the macular area was observed in OS on late ICG. Patient discontinued treatment with alendronate. She underwent weekly ocular examination up to 4 weeks. Her symptoms improved in OS with VA of 20/20 in 1 week after discontinuation. FA and ICG revealed some patched areas of irregular hypofluorescence surrounding the old spots due to filling defect of choroidal vessels and characterized by late staining of dye on FA and no leakage (Figures 2A and 2B). Hypofluorescent areas were shown on both intermediate and late ICG phases with reducing size compared to the acute phases in the same areas.Acute retinal pigment epithelitis (ARPE), also known as Krill's disease, is characterized by an acute and severe loss of vision in young, healthy adults with a self-limiting course and affecting both males and females equally [1]. It is thought to represent areas of RPE inflammation with breakdown of the pigment epithelial barrier and subsequent leakage of serous fluid. We report a case of a patient in which ARPE occurred after a long term administration of oral alendronate. These side effects are solved with discontinuation of therapy. A number of medications encompassing various forms of administration, including topical formulations, periocular and intraocular injections, and systemic medications, have been associated with uveitis. Bisphosphonates are primarily used to treat osteoporosis [2]. They are generally well tolerated, even though several medications in this class have been associated with uveitis or other ocular side effects [3]. Bisphosphona...

show abstract

“…Acute retinal pigment epitheliitis is one of the diseases of the macula, described for the first time by Krill and Deutman in 1972 [1]. The disease has an acute onset of vision blurring and is characterized by the appearance of sin gle or multiple grey-dark pigmented spots in the macular area, on the level of the retinal pigment epithelium, surrounded by a yellowwhite halo-like zone.…”

mentioning

confidence: 99%

Long-Term Observations of Patients with Acute Retinal Pigment Epitheliitis

Prost

1989

Ophthalmologica

View full text Add to dashboard Cite

Because of some authors presumptions that acute retinal pigment epitheliitis is not a distinct clinical entity but the early stage of other fundus diseases, the results of long-term observations of 5 patients with this disease are reported. The results of 6- to 7-year observations of these patients have shown that in none of them the fundus lesions developed into other retinal diseases. This indicates that acute retinal pigment epitheliitis is a distinct clinical entity.

show abstract

Acute Retinal Pigment Epitheliitus

Cited by 107 publications

References 9 publications

Unilateral Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Unilateral Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Retinal epithelitis as ocular side effects of oral biphosphonates

Long-Term Observations of Patients with Acute Retinal Pigment Epitheliitis

Contact Info

Product

Resources

About