Acute respiratory distress syndrome due to methicillin-resistant Staphylococcus aureus sepsis in hyper-IgE syndrome

Sato, Etsuro; Yamamoto, Hidehiko; Honda, Takayuki; Koyama, Shigeru; Kubo, Keishi; Sediguchi, M

doi:10.1183/09031936.96.09020386

Cited by 11 publications

(12 citation statements)

References 22 publications

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“…28,[82][83][84] Of note, bone marrow transplantation does not offer a cure for HIES. A severely affected patient had a successful bone marrow transplant but developed reappearance of the immunodeficiency.…”

Section: Clinical Manifestationsmentioning

confidence: 97%

“…Indeed, MRSA-induced sepsis with acute respiratory distress syndrome and disseminated intravascular coagulation has been reported. 60 TMP-SMX is a safe and effective alternative to penicillin; importantly, it has anti-MRSA properties. There have been reports of TMP-SMX effectively treating abscesses that were previously unresponsive to various antibiotics.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…In addition to staphylococcal and Aspergillus infections, there have been reports of nocardiosis, 26 Pneumocystis carinii pneumonia, 5 disseminated pulmonary candidiasis, 27 and acute respiratory distress syndrome with disseminated intravascular coagulation due to MRSA sepsis. 28 Infection with Aspergillus species is an important issue to consider. HIES and allergic bronchopulmonary aspergillosis (ABPA) can clinically mimic each other, and the effects of treatment can produce serious consequences if the diagnosis is not made accurately.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

DeWitt

Bishop

Buescher

et al. 2006

Journal of the American Academy of Dermatology

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Section: Clinical Manifestationsmentioning

confidence: 97%

Section: Clinical Manifestationsmentioning

confidence: 99%

Section: Clinical Manifestationsmentioning

confidence: 99%

See 1 more Smart Citation

Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

DeWitt

Bishop

Buescher

et al. 2006

Journal of the American Academy of Dermatology

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“…Lifetime penicillinase-resistant penicillins are reported to be safe and effective but a growing problem is the occurrence of MRSA and complications such as sepsis, ARDS, and DIC. [77] TMP-SMX is a safe and effective substitution to penicillins and has anti-MRSA coverage. Importantly, stopping of prophylactic antibiotic therapy will often lead to disease recurrence.…”

Section: Therapeuticsmentioning

confidence: 99%

Hyperimmunoglobulin E syndrome: Genetics, immunopathogenesis, clinical findings, and treatment modalities

et al. 2017

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The hyperimmunoglobulin E syndromes (HIESs) are very rare immunodeficiency syndromes with multisystem involvement, including immune system, skeleton, connective tissue, and dentition. HIES are characterized by the classic triad of high serum levels of immunoglobulin E (IgE), recurrent staphylococcal cold skin abscess, and recurrent pneumonia with pneumatocele formation. Most cases of HIES are sporadic although can be inherited as autosomal dominant and autosomal recessive traits. A fundamental immunologic defect in HIES is not clearly elucidated but abnormal neutrophil chemotaxis due to decreased production or secretion of interferon γ has main role in the immunopathogenesis of syndrome, also distorted Th1/Th2 cytokine profile toward a Th2 bias contributes to the impaired cellular immunity and a specific pattern of infection susceptibility as well as atopic-allergic constitution of syndrome. The ophthalmic manifestations of this disorder include conjunctivitis, keratitis, spontaneous corneal perforation, recurrent giant chalazia, extensive xanthelasma, tumors of the eyelid, strabismus, and bilateral keratoconus. The diagnosis of HIES is inconclusive, dependent on the evolution of a constellation of complex multisystemic symptoms and signs which develop over the years. Until time, no treatment modality is curative for basic defect in HIES, in terms of cytokines/chemokines derangement. Of note, bone marrow transplant and a monoclonal anti-IgE (omalizumab) are hoped to be successful treatment in future.

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“…Nur die lokale Symptomatik konnte hierdurch kurzzeitig positiv beeinflußt werden. [16] q Reduzierte Immunantwort auf Vakzination q Nachweis von zirkulierenden Immunkomplexen q Fakultativ: Eosinophilie im peripheren Blut q Fakultativ: verminderte Chemotaxis von neutrophilen Granulozyten Sekundäre Symptome (Komplikationen) q Lungenabszesse ("kalte Abszesse") q Abszesse in Leber, Nieren ("kalte Abszesse") q Septumabszeß mit konsekutiver Perforation [8] q Osteomyelitis q Meningitis q Pilzinfektionen (Candida albicans, Aspergillus spp., Cryptococcus neoformans) q Septische Komplikationen, ARDS [15] q Malignome (ibs. Lymphome) q Osteopenie, Osteoporose, Frakturanfälligkeit, verringerte Knochendichte nach oben und nach unten sind jedoch beschrieben.…”

Section: Introductionunclassified

Das Hyper-IgE-Syndrom mit HNO-Manifestationen

Waldfahrer

Pahl

Federspil

et al. 1999

HNO

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Hyperimmunoglobulin E syndrome (Hiob syndrome or Buckley syndrome) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck. Typical symptoms are fever, recurrent urticarial rashes, lymphadenitis, and bacterial infections of the skin and various parenchymatous organs. Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease. We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years. High-dose intravenous immunoglobulin therapy (IVIG) was found to be well-tolerated and effective. More than one year after a single course of immunoglobin therapy symptoms markedly improved. Current knowledge and therapeutic options in hyper IgE syndrome are discussed. We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome.

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Acute respiratory distress syndrome due to methicillin-resistant Staphylococcus aureus sepsis in hyper-IgE syndrome

Cited by 11 publications

References 22 publications

Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

Hyperimmunoglobulin E syndrome: Genetics, immunopathogenesis, clinical findings, and treatment modalities

Das Hyper-IgE-Syndrom mit HNO-Manifestationen

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