Acute respiratory distress syndrome: analysis of incidence and mortality in a university hospital critical care unit

Figueira, J. F.; Oliveros, M; López, Javier; Civantos, BC; Fernández, L

doi:10.1186/cc11003

Cited by 2 publications

(1 citation statement)

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“…1 Acute respiratory distress syndrome (ARDS) affects 190,000 patients annually and is associated with a mortality of 64%. 2 Chronic lung disease affects 12.7 million annually and is associated with a mortality of 135,000. 3,4 As lung disease becomes end stage, lung transplant is the only viable treatment.…”

Section: Introductionmentioning

confidence: 99%

Fiber Bundle Design for an Integrated Wearable Artificial Lung

Madhani¹,

Frankowski²,

Federspiel³

2017

ASAIO Journal

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Mechanical ventilation and ECMO are the only viable treatment options for lung failure patients at the end stage, including ARDS and COPD. These treatments however are associated with high morbidity and mortality due to long wait times for lung transplant. Contemporary clinical literature has shown ambulation improves post-transplant outcomes in lung failure patients. Given this, we are developing the PAAL, a truly wearable artificial lung that allows for ambulation. In this study, we targeted 180 ml/min oxygenation and determined the form factor for a hollow fiber membrane (HFM) bundle for the PAAL. Based on a previously published mass transfer correlation we modeled oxygenation efficiency as a function of fiber bundle diameter. Three benchmark fiber bundles were fabricated to validate the model through in-vitro blood gas exchange at blood flow rates from 1 to 4 L/min according to ASTM standards. We used the model to determine a final design, which was characterized in-vitro through a gas exchange as well as a hemolysis study at 3.5 L/min The percent difference between model predictions and experiment for the benchmark bundles ranged from 3% to 17.5% at the flowrates tested. Using the model, we predicted a 1.75 inch diameter bundle with 0.65 m2 surface area would produce 180 ml/min at 3.5 L/min blood flow rate. The oxygenation efficiency was 278 ml/min/m2 and the Normalized Index of Hemolysis (NIH) was less than 0.05g/100L. Future work involves integrating this bundle into the PAAL for which an experimental prototype is under development in our laboratory.

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Section: Introductionmentioning

confidence: 99%