Acute renal failure in the setting of the neuroleptic malignant syndrome

Korzets, Ze’ev; Zeltzer, Ella; Bernheim, Jacques

doi:10.1093/oxfordjournals.ndt.a027422

Cited by 11 publications

(3 citation statements)

References 11 publications

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“…The term known as NMS was first reported in 1960 by French psychiatrists [6]. The incidence of NMS is 0.02-3% in patients taking antipsychotic drugs [4].…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic Malignant Syndrome Associated with Rhabdomyolysis Induced by Antipsychotic Agents: A Rare Occurrence

2021

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Neuroleptic Malignant Syndrome (NMS) is a medical emergency of infrequent presentation in Emergency department, which is associated with the use of psychotropic agents, classical and atypical antipsychotics. We report a case involving a 56-year-old male patient diagnosed with schizophrenia and depression for 30 years, who had been receiving Amisulpride, Trifluoperazine, Clozapine, and Amitryptiline as part of his treatment. This patient presented with symptoms of NMS with fever, muscle rigidity, altered mental state, elevated CPK, Urea, and S. Creatinine levels. NMS may be responsible for serious rhabdomyolysis, acute respiratory distress syndrome, and disseminated intravascular coagulation. We hypothesize the occurrence of acute renal failure precipitated by NMS. His treatment included the withdrawal of all psychotropic agents, Bromocriptine, and other supportive measures.

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“…The term known as NMS was first reported in 1960 by French psychiatrists [6]. The incidence of NMS is 0.02-3% in patients taking antipsychotic drugs [4].…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic Malignant Syndrome Associated with Rhabdomyolysis Induced by Antipsychotic Agents: A Rare Occurrence

2021

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“…Associated acute renal failure is considered the most serious complication [ 15 ] and it is an independent predictor of mortality [ 16 ]; this is due to the intense rhabdomyolysis, deposit of myoglobin in the renal tubules, and dehydration, which occurs in about 16% of cases [ 17 ] with a mortality of 50% [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Leonardo

Juliana

Fernando

2017

Case Reports in Emergency Medicine

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The Neuroleptic Malignant Syndrome (NMS) is a medical emergency of infrequent presentation in the emergency department, which is associated with the use of psychiatric drugs, such as typical and atypical antipsychotics. Our case addresses a 55-year-old patient diagnosed with undifferentiated schizophrenia for 10 years, who had been receiving clozapine and clonazepam as part of their treatment. This patient presents the symptoms of Neuroleptic Malignant Syndrome without fever, which improves with treatment especially with the withdrawal of clozapine. In the absence of fever and clinical improvement, the patient is considered to have an atypical presentation of this disease.

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“…Mortality and morbidity rate are high among the NMS patients with mental retardation [29]. Acute renal failure develops in 16% of all cases of NMS and mortality increases by approximately 50 % [30,31].…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic malignant syndrome induced acute renal failure: Is mental retardation an additional risk factor?

Kayataş¹

2012

CMJ

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Neuroleptic malignant syndrome is a rare but serious complication of neuroleptic treatment. It is a disorder which is usually characterized by muscle contraction and changes in consciousness, extrapyramidal symptoms, hyperpyrexia and blood pressure irregularities that often depend on the use of conventional antipsychotic drugs. In this case report, we discuss acute renal failure induced by neuroleptic malignant syndrome developing on the basis of chronic kidney disease in a patient with mental retardation.

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Acute renal failure in the setting of the neuroleptic malignant syndrome

Cited by 11 publications

References 11 publications

Neuroleptic Malignant Syndrome Associated with Rhabdomyolysis Induced by Antipsychotic Agents: A Rare Occurrence

Neuroleptic Malignant Syndrome Associated with Rhabdomyolysis Induced by Antipsychotic Agents: A Rare Occurrence

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Neuroleptic malignant syndrome induced acute renal failure: Is mental retardation an additional risk factor?

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