Acute Renal Failure in the Dog and Cat

English, P. B.

doi:10.1111/j.1751-0813.1974.tb05343.x

Cited by 9 publications

(3 citation statements)

References 75 publications

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“…It is characterized by sudden kidney failure or a rapid loss of kidney function [3]. AKI has many potential causes, including renal ischemia from low blood pressure, crush injury, inflammation, and urinary tract obstruction or infection [4,5]. It is diagnosed based on elevated blood urea nitrogen (BUN) and creatinine concentrations, or decreased urine output [5].…”

Section: Introductionmentioning

confidence: 99%

Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Yun

Lee

2019

IJMS

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Kidney disease can be either acute kidney injury (AKI) or chronic kidney disease (CKD) and it can lead to the development of functional organ failure. Mesenchymal stem cells (MSCs) are derived from a diverse range of human tissues. They are multipotent and have immunomodulatory effects to assist in the recovery from tissue injury and the inhibition of inflammation. Numerous studies have investigated the feasibility, safety, and efficacy of MSC-based therapies for kidney disease. Although the exact mechanism of MSC-based therapy remains uncertain, their therapeutic value in the treatment of a diverse range of kidney diseases has been studied in clinical trials. The use of MSCs is a promising therapeutic strategy for both acute and chronic kidney disease. The mechanism underlying the effects of MSCs on survival rate after transplantation and functional repair of damaged tissue is still ambiguous. The paracrine effects of MSCs on renal recovery, optimization of the microenvironment for cell survival, and control of inflammatory responses are thought to be related to their interaction with the damaged kidney environment. This review discusses recent experimental and clinical findings related to kidney disease, with a focus on the role of MSCs in kidney disease recovery, differentiation, and microenvironment. The therapeutic efficacy and current applications of MSC-based kidney disease therapies are also discussed.

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Section: Introductionmentioning

confidence: 99%

Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Yun

Lee

2019

IJMS

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“…Proteinuria and gfucosuria -If protein is present in urine, it is important to estimate the actual quantity being lost daily, bearing in mind that a Ioss of approximately 2-3 mg/kg body weight per day could be significant (Relman and Levinsky 1971;English 1974), despite the fact that continuous proteinuria has been found in clinically 310 normal dogs (Stuart et al 1975). When determining and assessing the significance of urinary protein, the SG (or osmolality) of the urine sample being tested and the daily volume of urinary output must be taken into consideration.…”

Section: Urinary Constituentsmentioning

confidence: 99%

Clinical Assessment of Renal Function in the Dog With a Reduction in Nephron Number*

1980

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The viewpoint presented is that, because compensatory functional adjustment of the residual nephrons occurs in chronic renal disease, reduction in nephron number usually exceeds 70% before a diagnosis is made. The case that earlier diagnoses are likely if laboratory medicine values are measured and interpreted with a maximum of efficiency is then made. The laboratory data more commonly used in practice for the clinical assessment of renal function in the dog are presented and some comparisons with findings in man are made. The information originates from clinical and experimental observations of the authors, as well as from a literature review. The laboratory data presented and discussed includes glomerular filtration rate and the clearance of nitrogenous waste (urea and creatinine), plasma protein concentration, plasma osmolality, renal concentrating capacity, and urinary constituents, particularly its protein concentration and sediment (centrifuge deposit). All parameters recommended for the clinical assessment of chronic renal failure are considered qualitatively, and some are also dealt with quantitatively.

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“…Although BUN was elevated in 5 cats (35.71%), three out of five cats were not detected for fluke eggs in bile sample. Considering that, BUN was remarkable biomarker for kidney function in companion animal (English, 1974). As above mentioned facts, abnormal liver enzyme parameters, especially ALT and GGT might be elevated in P. fastosum infected cases.…”

Section: Discussionmentioning

confidence: 84%

Clinical diagnosis, ultrastructural study and antigenic characterization of platynosomum fastosum in cats

Soe¹

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Platynosomum fastosum is a cat liver fluke causing hepatobiliary diseases in cats. To evaluate the criterior to support the suspicion index for early disease detection during subclinical infection, the biochemical parameters composed of liver, pancreatic enzymes, tumor markers were evaluated in 14 P. fastosum naturally-infected cats. As a result, alanine transaminase (ALT) and gamma glutamyl transferase (GGT) were found elevated in 57.8% (8/14) of infected cats. For the diagnostic imaging, bile sediments were present in 85.7% (12/14) of infected cats in their gallbladders. Since the number of bile-derived P. fastosum eggs were significantly higher than that from fecal samples (p=0.001), percutaneous ultrasound-guided cholecystocentesis seemed to be promising to be implemented as a tool for final diagnosis. To establish the fundamental data on ultrastructural characteristics of P. fastosum adult and egg for further drug testing as no effective drug available, scanning electron microscope was used to reveal the tegumental surface in which it was covered with densely packed villous-like projections and papillae. Using transmission electron microscope, at least one type of tegumental cell was found producing 2 types of tegumental granules inside P. fastosum adult tegument. To develop serodiagnostic assay, antigenic components of P. fastosum were characterized and 3 immunogenic proteins (70kDa, 53kDa and 13kDa) were identified and the sequences were characterized.

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Acute Renal Failure in the Dog and Cat

Cited by 9 publications

References 75 publications

Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Clinical Assessment of Renal Function in the Dog With a Reduction in Nephron Number*

Clinical diagnosis, ultrastructural study and antigenic characterization of platynosomum fastosum in cats

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