Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Yun, Chul Won; Lee, Sang Hun

doi:10.3390/ijms20071619

Cited by 81 publications

(86 citation statements)

References 102 publications

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“…An interesting finding is that MSC-exosomes were preferentially accumulated in the kidneys of mice with glycerol-induced acute kidney injury compared to the distribution in normal mice [95]. The application of MSCs as a cell-based therapy for acute or chronic kidney disease has been studied [107]. MSC-exosomes have also been reported to be effective for kidney diseases in various animal models [108].…”

Section: Accumulation Of Msc-exosomes In Damaged Tissuesmentioning

confidence: 99%

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

Yi¹,

Lee²,

Kim

et al. 2020

IJMS

141

131

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Exosomes are nano-sized membranous vesicles produced by nearly all types of cells. Since exosome-like vesicles are produced in an evolutionarily conserved manner for information and function transfer from the originating cells to recipient cells, an increasing number of studies have focused on their application as therapeutic agents, drug delivery vehicles, and diagnostic targets. Analysis of the in vivo distribution of exosomes is a prerequisite for the development of exosome-based therapeutics and drug delivery vehicles with accurate prediction of therapeutic dose and potential side effects. Various attempts to evaluate the biodistribution of exosomes obtained from different sources have been reported. In this review, we examined the current trends and the advantages and disadvantages of the methods used to determine the biodistribution of exosomes by molecular imaging. We also reviewed 29 publications to compare the methods employed to isolate, analyze, and label exosomes as well as to determine the biodistribution of labeled exosomes.

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Section: Accumulation Of Msc-exosomes In Damaged Tissuesmentioning

confidence: 99%

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

Yi¹,

Lee²,

Kim

et al. 2020

IJMS

141

131

View full text Add to dashboard Cite

show abstract

“…Furthermore, this Special Issue contains important reviews that dealt with the current knowledge of cell death and regeneration [13,14], inflammation [15][16][17][18], and the molecular mechanisms of kidney diseases [19][20][21][22]. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells (MSCs) or their derivates is summarized [23][24][25]. This edition is complemented by a series of reviews that deal with the current data situation on other very specific topics like diabetes and diabetic nephropathy [26][27][28], as well as new therapeutic targets [29].In this Special Issue, twelve original research articles are presented that dealt with different questions and the research models used within.…”

mentioning

confidence: 99%

“…In this context, the main mechanisms of kidney regeneration, while focusing on epithelial cell dedifferentiation and the activation of progenitor cells with special attention on the potential niches of kidney progenitor cells, were also lighted [13]. Three reviews by Yun [25], Bochon [23] and Lee [24] summarized the therapeutic potential and efficacy of MSCs, which are primarily associated with their capability to inhibit inflammation and initiate renal regeneration. MSCs predominantly act through secreted factors, including microRNAs that are contained within extracellular vesicles, cytoprotective effects anti-inflammatory effects, anti-apoptotic effects, and the suppression of oxidative stress.…”

mentioning

confidence: 99%

Kidney Inflammation, Injury and Regeneration

Baer

Koch

Geiger

2020

IJMS

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Damage to kidney cells can occur due to a variety of ischemic and toxic insults and leads to inflammation and cell death, which can result in acute kidney injury (AKI). Inflammation plays a key role in the injury of renal cells, as well as subsequent cellular regeneration processes. However, persistent chronic inflammation may trigger renal fibrosis. The investigation of the molecular mechanisms involved in each individual injury is currently insufficiently elucidated. Whereas the kidney has a remarkable capacity for regeneration after injury and may completely recover depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. AKI is still associated with high morbidity and mortality incidence rates, and it also bears an elevated risk of subsequent chronic kidney disease. Therefore, the development of novel therapies to improve renal regeneration capacity after AKI, to preserve renal function, and to prevent AKI is urgently needed. In this context, we wanted to offer a forum for the publication of new results on renal inflammation, injury and regeneration, as well as for the review and discussion of existing studies from this interesting research field.This Special Issue covers research articles that investigated the molecular mechanisms of inflammation [1-3] and injury [4,5] during different renal pathologies and renal regeneration [6], diagnostics using new biomarkers [7-9], and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models [10][11][12], all of which were summarized in a very simplified manner. Furthermore, this Special Issue contains important reviews that dealt with the current knowledge of cell death and regeneration [13,14], inflammation [15][16][17][18], and the molecular mechanisms of kidney diseases [19][20][21][22]. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells (MSCs) or their derivates is summarized [23][24][25]. This edition is complemented by a series of reviews that deal with the current data situation on other very specific topics like diabetes and diabetic nephropathy [26][27][28], as well as new therapeutic targets [29].In this Special Issue, twelve original research articles are presented that dealt with different questions and the research models used within. The findings of Mocker and co-workers demonstrate that renal chemerin expression, a chemoattractant adipokine, is associated with processes of inflammation and fibrosis during renal damage [2]. The protection of kidney function by attenuating induced renal inflammation was shown with the use of Farnesiferol B, an agonist of a receptor that is expressed by renal tubular epithelial cells [1]. The xanthin oxidase inhibitor febuxostat is shown to exert anti-inflammatory action and protect against diabetic nephropathy development [3]. Kidney injury leading to focal segmental glomerulosclerosis was shown by variants in the collagen 4A5 g...

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“…Unlike our study, that meta-analysis included mesenchymal stem cells, endothelial progenitor cells, hematopoietic stem cells, and bone marrow cells (Papazova et al, 2015) so the included studies involved a diversity of disease models. Mesenchymal stem cell-based therapy has been shown to improve renal function and recovery of damaged renal tissues in animal studies (Yun and Lee, 2019), but it has yet to produce strong positive results in clinical trials (Yun and Lee, 2019). Most clinical studies using hematopoietic stem cell therapy have focused on lupus nephritis and have lacked a control group or randomization (El-Ansary et al, 2012;Alchi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cells as a Novel Candidate for Cell-Based Therapy in Kidney Disease

Zhang

Chen

et al. 2020

Front. Physiol.

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Kidney disease is a significant health concern worldwide. Ineffective treatment can lead to disastrous consequences, such as organ failure and death. Research has turned to cell-based therapy, but has yet to produce an effective and reliable treatment for kidney disease. To address this problem, we examined four datasets of gene expression profiles from diseased and healthy kidney tissue in humans, mice, and rats. Differentially expressed genes (DEGs) were screened and subjected to enrichment analyses. Upregulated genes in diseased kidney tissue were significantly enriched in pathways associated with regulatory T cells (Tregs). Analysis with the xCell tool showed that Tregs were generally increased in diseased kidney tissue in all species. To validate these results in vivo, kidneys were removed from mice with Adriamycin-induced nephropathy, and histology confirmed increase of Tregs. Furthermore, Tregs were adoptively transferred from healthy mice into mice with kidney injury, restoring normal structure to the damaged kidneys. Treg cells that were co-cultured with M2c macrophages exhibited up-regulation of chemokine receptors CCR2, CCR5, CCR7, CD62L, and CX3CR1. This may be the mechanism by which M2c cells enhance the migration of Tregs to the site of inflammation. We propose that Tregs may be an effective, novel candidate for cell-based therapy in pre-clinical kidney injury models.

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Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease

Cited by 81 publications

References 102 publications

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

Kidney Inflammation, Injury and Regeneration

Regulatory T Cells as a Novel Candidate for Cell-Based Therapy in Kidney Disease

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