Acute renal failure in Congolese children: a tertiary institution experience

Aloni, Michel Ntetani; Nsibu, Célestin Ndosimao; Meeko-Mimaniye, Mobuli; Ekulu, Pépé Mfutu; Bodi, Joseph M.

doi:10.1111/j.1651-2227.2012.02827.x

Cited by 39 publications

(38 citation statements)

References 21 publications

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“…Studies of Olowu [5] in Nigeria reveal the financial problem that is present there; in Aloni only 10.9% of patients have the ability to gain access to PD and in the Congo [6] only 26% of patients have that capacity. The conditions of admission to the UNP are not always within the reach of the financial capacities of the parents.…”

Section: Discussionmentioning

confidence: 99%

Acute Peritoneal Dialysis in African Pediatric Area Experience of Pediatric Nephrology Unit of Yopougon University Hospital (Abidjan, Côte d'Ivoire)

Diarrassouba

Adonis-Koffy²,

Niamien³

et al. 2015

Blood Purif

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Introduction: Acute kidney injury (AKI) is a diagnostic emergency threatening patients in a major way. Pediatric renal extra purification methods are limited in African countries due to the nonavailability of resources. Peritoneal dialysis (PD) seems to be the modality that is the most practiced for children with acute renal failure (ARF). Methodology: We conducted a retrospective study on 5 years of records of children from 1 month to 15 years who have suffered an ARF and benefited from PD while being treated at the pediatric nephrology unit of the Chu of Yopougon. ARF is defined as the condition that exists when the serum creatinine level is high or equal to 200 µmol/l outside any underlying uropathies. Results: Out of the hospitalized 88 children for AKI, 33 were on PD. Twenty-two children have been on dialysis while 9 children had to discontinue treatment due to financial problems. The sex ratio was 0.46 and the average age was 8.1. The etiologies of the AKI were predominantly glomerular diseases (45%), malaria (31.8%), and secondary interstitial nephritis of toxic origin. The indications of the PD are anuria (31%), hyperkalemia (18%), acute edema of lung (13%), and hyperuremia (13%). Eight children had automated peritoneal dialysis, 02 children underwent manual PD, and 9 children had both methods of treatment. We recorded 31 mechanical complications and 10 infections. While 8 children died, 10 recovered from AKI. Conclusion: Trained surgical medical personnel and favorable economic statuses of patients are the factors that will determine the success of PD in our country.

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Section: Discussionmentioning

confidence: 99%

Acute Peritoneal Dialysis in African Pediatric Area Experience of Pediatric Nephrology Unit of Yopougon University Hospital (Abidjan, Côte d'Ivoire)

Diarrassouba

Adonis-Koffy²,

Niamien³

et al. 2015

Blood Purif

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“…Probably this renal impairment is under-reported in African children, poverty and the paucity of pediatric nephrologists and hematologists in this region should contribute to this fact. In addition, SCD and renal diseases are not regarded as a major health problem in DRC confronted to infectious diseases and malnutrition [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Renal Function in Children Suffering from Sickle Cell Disease: Challenge of Early Detection in Highly Resource-Scarce Settings

et al. 2014

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BackgroundThe prevalence of Sickle cell disease is extremely high in Democratic Republic of Congo. Despite this high prevalence of the disease, data on renal abnormalities in children are rare.MethodThe study proposed to assess blood pressure, glomerular function, urea and uric acid levels in 65 steady state Congolese children with homozygous sickle cell disease and 67 normal controls.ResultsIn Hb-SS group, blood pressure level tended to be lower than Hb-AA groups but there was no statistically significant difference (p>0.05) between the two groups. The absolute values for GFR corrected for BSA were significantly higher in Hb-SS group compared to Hb-AA group (130.5±34.1 ml/min/1.73 m2 vs 113.7±24.5 ml/min/1.73 m2; p = 0.004). Children with Hb-SS were more likely to hyperfiltrate (30.8% of subjects) than children with Hb-AA (6.1% of subjects). Proteinuria was found in 4 (6.2%) children with Hb-SS. Uric acid level was significantly increased in children with Hb-SS compared to corresponding values in control group (4.4±1.3 mg/dl vs 3.5±1.1 mg/dl; p<0.001). Urea level was significantly decreased compared to corresponding values in Hb-AA group (15.3±8.3 mg/dl vs 22.9±10.1 mg/dl; p<0.001).ConclusionHyperfiltration, low creatinine, lower urea and high uric acid are more common in children with sickle cell disease than in normal controls.

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“…Parasitic infections such as schistosomiasis, postinfectious glomerulonephritis, HIV-related nephropathy, and sickle disease all cause damage to the kidney in childhood and are more common in SSA (11–14). In addition, acute kidney disease is more common among children in SSA, particularly due to higher rates of diarrhea, and may progress to CKD (15–17). …”

Section: Introductionmentioning

confidence: 99%

Kidney disease among children in sub-Saharan Africa: systematic review

et al. 2014

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The global burden of kidney disease is increasing, and several etiologies first begin in childhood. Risk factors for pediatric kidney disease are common in Africa, but data regarding its prevalence are lacking. We completed a systematic review of community-based studies describing the prevalence of proteinuria, hematuria, abnormal imaging, or kidney dysfunction among children in sub-Saharan Africa. Medline and Embase were searched. Five hundred twenty-three references were reviewed. Thirty-two references from 9 countries in sub-Saharan Africa were included in the qualitative synthesis. The degree of kidney damage and abnormal imaging varied widely: proteinuria 32.5% (2.2%-56.0%); hematuria 31.1% (0.6%-67.0%); hydronephrosis 11.3% (0.0%-38.0%), hydroureter 7.5% (0.0%-26.4%), major kidney abnormalities 0.1% (0.0%-0.8%). Serum creatinine was reported in four studies with insufficient detail to identify the prevalence renal dysfunction. A majority of the studies were performed in Schistosoma haematobium endemic areas. A lower prevalence of kidney disease was observed in the few studies from non-endemic areas. Published data on pediatric kidney disease in sub-Saharan Africa is highly variable and dependent on S. haematobium prevalence. More community-based studies are needed to describe the burden of pediatric kidney disease, particularly in regions where S. haematobium infection is non-endemic.

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Acute renal failure in Congolese children: a tertiary institution experience

Abstract: A wide spectrum of features was seen in hospitalized Acute Renal Failure children and limited access to Acute Peritoneal Dialysis remained an important mortality risk factor.

Cited by 39 publications

References 21 publications

Acute Peritoneal Dialysis in African Pediatric Area Experience of Pediatric Nephrology Unit of Yopougon University Hospital (Abidjan, Côte d'Ivoire)

Acute Peritoneal Dialysis in African Pediatric Area Experience of Pediatric Nephrology Unit of Yopougon University Hospital (Abidjan, Côte d'Ivoire)

Renal Function in Children Suffering from Sickle Cell Disease: Challenge of Early Detection in Highly Resource-Scarce Settings

Kidney disease among children in sub-Saharan Africa: systematic review

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