Acute Renal Failure Due to Proliferative Nephritis from Snake Bite Poisoning

Seedat, Y K; Reddy, Jayarami; Edington, D. A.

doi:10.1159/000180424

Cited by 29 publications

(11 citation statements)

References 2 publications

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“…In some instances the severe form of glomerulonephritis may occur. Extracapillary proliferative glomerulonephritis with fibrin deposition and crescent formation without immunoglobulins and C3 has been shown in puff adder bite 19 and Russell’s viper bite 39 . Diffuse proliferative glomerulonephritis can be observed in occasional green pit viper bite victims 20 …”

Section: Renal Pathologymentioning

confidence: 99%

“…The clinical evidence suggests direct nephrotoxicity of the venom. Mesangiolysis, 33,34 glomerulonephritis 19,20 , 39 and vasculitis 9,38 without immunologic clues indicate direct glomerular and vascular injury by the venom. Venomous snakes have enzymes that can directly cause cellular injury.…”

Section: Pathogenesismentioning

confidence: 99%

“…The incidence can be as high as 35% 16 . Although not common, nephritic syndrome has been described in viper bite with pathological changes of diffuse proliferative and crescentic glomerulonephritis 19,20 . There is some diminution of renal function.…”

Section: Clinical Renal Manifestationsmentioning

confidence: 99%

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Snakebite nephropathy (Review Article)

2006

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SUMMARY:There is a broad clinical spectrum of renal involvement in snakebite. Besides the local and systemic symptoms, clinical renal manifestations vary from mild proteinuria, haematuria, pigmenturia to acute renal failure. Bites by haemotoxic snakes and myotoxic snakes are the common causes of renal involvement especially acute renal failure. Therefore, renal failure is often associated with haemorrhagic diathesis, intravascular haemolysis and rhabdomyolysis. Renal pathological changes include mesangiolysis, glomerulonephritis, vasculitis, tubular necrosis, interstitial nephritis and cortical necrosis. Tubular necrosis is an important pathological counterpart of acute renal failure. Haemodynamic alterations induced by cytokines and vasoactive mediators leading to renal ischaemia are important in the pathogenesis of acute renal failure. Haemolysis, intravascular coagulation and rhabdomyolysis are important contributing factors. Direct nephrotoxicity can be induced by the venom through metalloproteases and phosphilipase A 2. Immunologic mechanism plays a minor role in the pathogenesis of the renal lesion.

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Section: Renal Pathologymentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

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Snakebite nephropathy (Review Article)

2006

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“…In 1960, Steinbeck [3] described a patient who developed nephrotic syndrome following snakebite. Seedat et al [4] reported two patients who developed glomerulonephritis following puff adder bite.…”

Section: Discussionmentioning

confidence: 99%

Snakebite-induced acute renal failure

Karthik

Phadke

2004

Pediatr Nephrol

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Snakebite is not an uncommon cause of acute renal failure (ARF) in developing countries. We report a12-year-old boy who presented with oliguric ARF following snakebite. He had pallor, icterus, generalized edema, hypertension, and was oliguric. Investigations revealed severe azotemia, microangiopathic hemolytic anemia, thrombocytopenia, prolonged coagulation parameters, and raised fibrin degradation products, suggesting disseminated intravascular coagulation as the cause of ARF. The patient improved with antisnake venom, dialysis, and other supportive treatment.

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“…Über primär nephrotoxische Giftkomponenten ist vergleichsweise wenig bekannt. Unter der Gifteinwirkung kommt es zur Entwicklung einer proliferativen Glomerulonephritis, selten zu interstitiellen Nephritiden [46,47]. Bei einigen Vipernarten (Sandrasselottern (Bitis arietans), Kettenvipern (Vipera russelli spp.))…”

Section: Renale Gifteffekteunclassified

Gefahren durch Gifttiere - Unfälle mit Giftschlangen

Erkens¹,

Boecken²

2004

Anasthesiol Intensivmed Notfal

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In regions where poisonous animals are widely distributed, the management of injuries due to these animals is part of the routine medical care. Personnel e. g. deployed for humanitarian aid missions in these areas have to be prepared to face these challenges as well. Beside this group zoo personnel and snake charmers here in Europe are also endangered. The most common form of animal poisoning is due to snake bites. There are approximately 600 different species of poisonous snakes, commonly found in the warm climatic regions. But poisoning from spiders, scorpions and some marine animals can also be life threatening. There are different kinds of snake venoms, which result into different clinical presentations depending on the components of the venom. The venom may be cytotoxic, hematotoxic, neurotoxic, rhabdomyolytic, cardiotoxic, renotoxic or may cause an autoimmune reaction by complement activation. In the management of injuries following animal poisoning, besides the first aid measures taken, the injured is supposed to be managed according to the poison component in the venom with specific antivenin treatment and supportive therapeutic care. There are mono- and polyvalent antivenins available. Noneffective first-aid measures or measures which can cause further trauma must always be avoided. In general adapted behaviour in the field can prevent envenomation. Education on preventive measures with the aim of behaviour change are central components for pre-deployment preparations.

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Acute Renal Failure Due to Proliferative Nephritis from Snake Bite Poisoning

Cited by 29 publications

References 2 publications

Snakebite nephropathy (Review Article)

Snakebite nephropathy (Review Article)

Snakebite-induced acute renal failure

Gefahren durch Gifttiere - Unfälle mit Giftschlangen

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