Acute renal failure due to rifampicin: A study of 25 patients

Muthukumar, Thangamani; Jayakumar, M; Fernando, Edwin; Muthusethupathi, M. A.

doi:10.1053/ajkd.2002.35675

Cited by 89 publications

(75 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies suggest that it is either a type II or type III hypersensitivity reaction induced by rifampin antigens in which anti-rifampin antibodies form immune complexes that are deposited in renal vessels, the glomerular endothelium, and the interstitial area [7]. These reactions cause two different pathologic changes in the kidneys.…”

Section: Discussionmentioning

confidence: 99%

Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug

Rudraraju¹,

Parvathagiri²,

Dugar³

2017

JCR

View full text Add to dashboard Cite

Background: Interstitial nephritis, complication of anti-tubercular therapy has been most commonly reported due to rifampin therapy. The mechanism of rifampin-induced acute kidney injury is either a type II or type III hypersensitivity reaction induced by rifampin antigens in which anti-rifampin antibodies form immune complexes that are deposited in renal vessels, the glomerular endothelium, and the interstitial area. Case Report: We describe a case of 57-year-old man with rheumatoid arthritis who developed acute kidney injury with prominent tubular dysfunction after starting anti-tubercular therapy containing rifampin. Conclusion: Acute tubulo-interstitial nephritis should be included in the differential diagnosis in acute kidney injury and renal tubular damage following rifampin initiation.

show abstract

Section: Discussionmentioning

confidence: 99%

Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug

Rudraraju¹,

Parvathagiri²,

Dugar³

2017

JCR

View full text Add to dashboard Cite

show abstract

“…1 According to the few case series published in the literature several histopathologic patterns have been described: acute tubular necrosis (ATN), acute interstitial nephritis (AIN) and less often rapidly progressing glomerulonephritis and light chain proteinuria.…”

Section: Discussionmentioning

confidence: 99%

“…This classification has been questioned by others 1,11 as it appears that AIN is often present after intermittent administration of rifampicin.…”

Section: 2610mentioning

confidence: 99%

“…In addition, postrifampicin ARF has a favorable course with 96% of patients reaching full recovery of renal function 3 months from onset although deaths have been reported. 1,6 Based on the patients' renal function at discharge, it is probable that he will experience a full recovery.…”

Section: 2610mentioning

confidence: 99%

“…Hepatotoxicity is the most frequently observed side effect, however adverse reactions of immunologic nature such as acute renal failure (ARF), hemolysis, thrombocytopenia and disseminated intravascular coagulation have also been reported. [1][2][3][4] According to the ATS recommendations for the treatment of tuberculosis, it is not necessary to routinely monitor renal function in the course of treatment 5 and most chest physicians are probably not aware of rifampicin-associated renal failure. In the present report, we describe the case of hemolysis and severe ARF due to rifampicin in a patient suffering from pulmonary tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication

et al. 2013

View full text Add to dashboard Cite

Rifampicin is a widely used anti-tuberculosis agent. Apart from hepatotoxicity, rifampicin can rarely lead to adverse reactions of immunologic nature such as acute renal failure (ARF). We report the case of 57-year-old previously healthy man under treatment for pulmonary tuberculosis who presented with hemolysis and severe ARF. Rifampicin was discontinued and the patient was treated with fluid repletion, iv furosemide and dialysis therapy. Kidney biopsy revealed acute tubulointerstitial nephritis with no evidence of granulomas. The patient significantly improved and was discharged after 51 days of hospitalization. Clinicians using rifampicin should be aware of this rather uncommon but severe complication.

show abstract

Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review

et al. 2006

View full text Add to dashboard Cite

Diclofenac has been implicated in many cases of life-threatening immune hemolytic anemia (IHA). Nevertheless, confusion still occurs at the bedside and in the laboratory. Herein we report nine new patients and summarize all published cases (total, n = 61). Direct and indirect antiglobulin tests were performed according to standard procedures. Tests for drug-dependent antibodies were performed in the presence and absence of the target drugs and their ex vivo antigens (in the urine of patients treated with the drug). Diclofenac-and/or ex-vivo-antigen-dependent red cell antibodies were detected in all new cases. We identified nine new cases with diclofenac-dependent IHA. All cases were initially suspected to have an abdominal illness and/or autoimmune hemolytic anemia of warm type. Acute renal failure was present in three of the 9 new patients and in 20 of 37 published patients. Seven of the 46 patients died (15%), and clinical information is lacking in 15 other published cases. Diclofenac-dependent and/or ex-vivo-antigendependent IHA should always be considered when a patient on diclofenac develops acute renal failure and/or IHA. Am.

show abstract

Acute renal failure due to rifampicin: A study of 25 patients

Cited by 89 publications

References 15 publications

Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug

Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug

Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication

Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review

Contact Info

Product

Resources

About