Acute Renal Failure Complicating Severe Acute Pancreatitis

Kes, Petar; Vučičević, Željko; Ratković-Gusić, Iva; Fotivec, A

doi:10.3109/08860229609047686

Cited by 63 publications

(40 citation statements)

References 11 publications

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“…In our study, there were 49 cases complicated with AKI (33.8%) out of 145 patients with SAP. The mortality rate of those AKI patients was 49.0%, which was similar with that reported in the previous studies [1][2][3][4]. Mechanisms by which SAP can induce AKI include reducing circulating blood volume and insufficient kidney filling, which can induce ischemia and anoxia, causing damage to the kidneys.…”

Section: Discussionsupporting

confidence: 83%

Correlation analysis of computed tomography imaging score with the presence of acute kidney injury in severe acute pancreatitis

Zhang

Huang

et al. 2014

Abdom Imaging

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Section: Discussionsupporting

confidence: 83%

Correlation analysis of computed tomography imaging score with the presence of acute kidney injury in severe acute pancreatitis

Zhang

Huang

et al. 2014

Abdom Imaging

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“…AKI in the setting of AP was associated with a 10-fold increase in mortality (74.7% versus 7%) in a study of 563 patients [20]. A similar result was reported in another study, showing 71.2% mortality versus 6.8% in severe acute pancreatitis (SAP) patients with and without AKI [21].…”

Section: Discussionsupporting

confidence: 73%

Procalcitonin Levels Predict Acute Kidney Injury and Prognosis in Acute Pancreatitis: A Prospective Study

et al. 2013

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BackgroundAcute kidney injury (AKI) has been proposed as a leading cause of mortality for acute pancreatitis (AP) patients admitted to the intensive care unit (ICU). This study investigated the predictive value of procalcitonin (PCT) for AKI development and relevant prognosis in patients with AP, and compared PCT’s predictive power with that of other inflammation-related variables.MethodsBetween January 2011 and March 2013, we enrolled 305 cases with acute pancreatitis admitted to ICU. Serum levels of PCT, serum amyloid A (SAA), interleukin-6 (IL-6), and C reactive protein (CRP) were determined on admission. Serum PCT was tested in patients who developed AKI on the day of AKI occurrence and on either day 28 after occurrence (for survivors) or on the day of death (for those who died within 28 days).ResultsSerum PCT levels were 100-fold higher in the AKI group than in the non-AKI group on the day of ICU admission (p<0.05). The area under the receiver-operating characteristic (ROC) curve of PCT for predicting AKI was 0.986, which was superior to SAA, CRP, and IL-6 (p<0.05). ROC analysis revealed all variables tested had lower predictive performance for AKI prognosis. The average serum PCT level on day 28 (2.67 (0.89, 7.99) ng/ml) was significantly (p<0.0001) lower than on the day of AKI occurrence (43.71 (19.24,65.69) ng/ml) in survivors, but the serum PCT level on death (63.73 (34.22,94.30) ng/ml) was higher than on the day of AKI occurrence (37.55 (18.70,74.12) ng/ml) in non-survivors, although there was no significant difference between the two days in the latter group (p = 0.1365).ConclusionSerum PCT is superior to CRP, IL-6, and SAA for predicting the development of AKI in patients with AP, and also can be used for dynamic evaluation of AKI prognosis.

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“…SAP has been associated with an increased mortality, estimated from 7% to 47% (4,5). Acute renal failure (ARF) in the setting of AP has been shown to have a 10-fold increase in mortality (74.7% versus 7%) in a study of 563 patients (6). A similar result was reported in another study, showing 71.2% mortality versus 6.8% in SAP patients with or without ARF (7).…”

Section: Introductionmentioning

confidence: 99%

Acute renal failure in severe pancreatitis: A population-based study

Lin

Lai

et al. 2011

Upsala Journal of Medical Sciences

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IntroductionAcute pancreatitis (AP) is a common illness with varied mortality and morbidity. Patients with AP complicated with acute renal failure (ARF) have higher mortality than patients with AP alone. Although ARF has been proposed as a leading mortality cause for AP patients admitted to the ICU, few studies have directly analyzed the relationship between AP and ARF.MethodsWe performed a retrospective study using the population-based database from the Taiwan National Health Insurance Research Database (NHIRD). In the period from 1 January 2005 to 31 December 2005, every patient with AP admitted to the ICU was included and assessed for the presence of ARF and mortality risk.ResultsIn year 2005, there were a total of 221,101 admissions to the ICU. There were 1,734 patients with AP, of which 261 (15.05%) patients also had a diagnosis of ARF. Compared to sepsis and other critical illness, patients with AP had a higher risk of having a diagnosis of ARF, and patients with both diagnoses had a higher mortality rate in the same ICU hospitalization.ConclusionAP is associated with a higher risk of ARF, and, when both conditions exist, a higher risk of mortality is present.

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Acute Renal Failure Complicating Severe Acute Pancreatitis

Cited by 63 publications

References 11 publications

Correlation analysis of computed tomography imaging score with the presence of acute kidney injury in severe acute pancreatitis

Correlation analysis of computed tomography imaging score with the presence of acute kidney injury in severe acute pancreatitis

Procalcitonin Levels Predict Acute Kidney Injury and Prognosis in Acute Pancreatitis: A Prospective Study

Acute renal failure in severe pancreatitis: A population-based study

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