Acute renal failure in severe pancreatitis: A population-based study

Lin, Hung Yuan; Lai, Jiun-I; Lai, Yi Chun; Lin, Po Chou; Chang, Shih Chieh; Tang, Gau Jun

doi:10.3109/03009734.2010.547636

Cited by 65 publications

(43 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have asserted that renal failure is always one of the main drivers in multi‐organ failure due to SAP . The main pathophysiology is initiated as an uncontrolled systemic inflammatory process with ensuing hypovolaemia, either from wide‐spread vasodilation or fluid sequestration, and reduced tissue perfusion, which ultimately causes organ damage and failure, even multi‐organ failure . We show that multi‐organ failure is an important prognostic factor in SAP induced‐AKI as reported previously …”

Section: Discussionsupporting

confidence: 80%

“…Our results suggest that AKI patients experience a significantly higher ICU mortality compared with those who never develop AKI during intensive care (20.5% vs 44.9%, P < 0.001), which is consistent with published reports. 24,25 The mortality in the AKI III group is the highest at 55.6% compared with the AKI I and II groups. Moreover, more advanced AKIN classifications are associated with higher rates of ICU mortality, in an approximately linear fashion.…”

Section: Discussionmentioning

confidence: 98%

“…Patients with a history of renal disease who develop SAP have a significant risk factor for developing AKI, but it is not an independent prognostic factor, in contradiction with some studies. 5,24,26 Meanwhile, our conclusion that the type of treatment, except for RRT, is not independently associated with ICU mortality also contrasts with studies that focused on other types of nephrology. 12,[27][28][29] Several studies have asserted that renal failure is always one of the main drivers in multi-organ failure due to SAP.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of acute kidney injury on mortality and hospital stay in patient with severe acute pancreatitis

Zhou

Tang

et al. 2015

Nephrology

View full text Add to dashboard Cite

The paper represents the first attempt to investigate the etiology and epidemiology of AKI following SAP under the AKIN criteria among critically ill patients. Several independent risk factors were found to be associated with ICU mortality for AKI patients. The findings may pinpoint crucial therapeutic measures for preventing AKI among a vulnerable population and for more effective management of SAP-induced AKI to improve the quality of intensive care.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of acute kidney injury on mortality and hospital stay in patient with severe acute pancreatitis

Zhou

Tang

et al. 2015

Nephrology

View full text Add to dashboard Cite

show abstract

“…It contained home care visits, ambulatory care, out-patient care, prescription drugs, and medical record that was encoded by using the International Classification of Disease, 9- revision, Clinical Modification (ICD-9-CM) [24]. …”

Section: Methodsmentioning

confidence: 99%

Bronchial asthma is associated with increased risk of chronic kidney disease

Huang

et al. 2014

BMC Pulm Med

View full text Add to dashboard Cite

BackgroundBronchial asthma influences some chronic diseases such as coronary heart disease, diabetes mellitus, and hypertension, but the impact of asthma on vital diseases such as chronic kidney disease is not yet verified. This study aims to clarify the association between bronchial asthma and the risk of developing chronic kidney disease.MethodsThe National Health Research Institute provided a database of one million random subjects for the study. A random sample of 141 064 patients aged ≥18 years without a history of kidney disease was obtained from the database. Among them, there were 35 086 with bronchial asthma and 105 258 without asthma matched for sex and age for a ration of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing chronic kidney disease during a three-year follow-up period.ResultsOf the subjects with asthma, 2 196 (6.26%) developed chronic kidney disease compared to 4 120 (3.91%) of the control subjects. Cox proportional hazards regression analysis revealed that subjects with asthma were more likely to develop chronic kidney disease (hazard ratio [HR]: 1.56; 95% CI: 1.48-1.64; p < 0.001). After adjusting for sex, age, monthly income, urbanization level, geographic region, diabetes mellitus, hypertension, hyperlipidemia, and steroid use, the HR for asthma patients was 1.40 (95% CI: 1.33-1.48; p = 0.040). There was decreased HRs in steroid use (HR: 0.56; 95% CI: 0.62-0.61; p < 0.001) in the development of chronic kidney disease. Expectorants, bronchodilators, anti-muscarinic agents, airway smooth muscle relaxants, and leukotriene receptor antagonists may also be beneficial in attenuating the risk of chronic kidney disease.ConclusionsPatients with bronchial asthma may have increased risk of developing chronic kidney disease. The use of steroids or non-steroidal drugs in the treatment of asthma may attenuate this risk.

show abstract

“…SAP is often complicated by acute kidney injury, either isolated or part of MOF (Peride et al, 2011). Patients with SAP complicated with acute kidney injury are associated with a higher mortality than patients with acute pancreatitis alone (Lin et al, 2011;Bishehsari et al, 2012). Multiple studies have demonstrated that sepsis is the leading cause of acute renal failure among risk factors like polytrauma, burns, pancreatitis, cardiopulmonary bypass, and others.…”

Section: Ratio Of Apoptosis Of Renal Tissues By Tunelmentioning

confidence: 99%

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

Dang

Zeng

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Background and objective: It has been shown that macrophages play an important role in the development of severe acute pancreatitis (SAP), and eventually lead to multiple organ failure (MOF). Clodronate-liposome selectively depleted macrophages. This study was to investigate the role of renal macrophage infiltration in acute renal injury in rats with SAP and to evaluate the potential of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) for diagnosis. Methods: Superparamagnetic Fe 3 O 4 nanoparticles were prepared by chemical coprecipitation. SPIO-liposomes and SPIO-clodronate-liposomes were prepared by the thin film method. SAP models were prepared by injection of sodium taurocholate into the subcapsular space of rat pancreas. Sprague-Dawley rats were randomly divided into a control group, SAP plus SPIO-liposome (P) group, and SAP plus SPIO-clodronatecontaining liposome (T) group. Kidney injury was evaluated by T2-weighted MRI scan. The levels of serum amylase (SAM), blood urea nitrogen (BUN), and serum creatinine (SCr) were measured by an automated enzymatic method. Serum tumor necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA). Pathological changes in the pancreas and kidney were observed using hematoxylin and eosin (H&E) staining, while cell apoptosis was detected with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In addition, the macrophage markers (CD68) of the renal tissue were detected with immunohistochemistry. Results: The pathological changes in the pancreas and kidneys of rats in the T group were milder than those in the P group. The MRI signal intensity of the kidneys in the P and T groups was significantly lower than that in the control group. There were significant changes in the two experimental groups (P<0.01). The levels of SAM, Bun, SCr, and TNF-α in rats in the P group were higher than those in the control group (P<0.01) and in the T group (P<0.01). The apoptosis of the kidney in the T group was higher than that in the P group at 2 and 6 h (P<0.01). Conclusions: Clodronate-containing liposomes protected against renal injury in SAP rats, and SPIO can be used as a tracer for MRI examination to detect renal injury in SAP rats. SPIO-aided MRI provided an efficient non-invasive way to monitor the migration of macrophages after renal injury in rats with SAP.

show abstract

Acute renal failure in severe pancreatitis: A population-based study

Cited by 65 publications

References 12 publications

Effect of acute kidney injury on mortality and hospital stay in patient with severe acute pancreatitis

Effect of acute kidney injury on mortality and hospital stay in patient with severe acute pancreatitis

Bronchial asthma is associated with increased risk of chronic kidney disease

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

Contact Info

Product

Resources

About