Acute renal failure associated with<i>Amaranthus</i>species ingestion by lambs

Kessell, Allan; Boulton, J.; Krebs, Gaye; Quinn, Jane C.

doi:10.1111/avj.12331

Cited by 12 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The four kinds of amaranth seeds were selected for sprouting as they are edible, widely available on the market and popular in cuisine over the world to replace flour, grains and vegetables [ 13 , 26 , 27 ]. Some of amaranth species, in particular, Amaranthus retroflexus and Amaranthus hybridus , may be harmful for living organism due to high levels of oxalates and nitrate/nitrite that may cause acute renal necrosis and perirenal oedema in ruminants, swine and horses [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Selenium Supplementation of Amaranth Sprouts Influences Betacyanin Content and Improves Anti-Inflammatory Properties via NFκB in Murine RAW 264.7 Macrophages

Tyszka-Czochara

Paśko

Zagrodzki

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

Sprouts contain potent compounds which while influencing crucial transduction pathways in cell reveal anti-inflammatory and anticancer activities. In this study, we report the biological activity for seeds and colourful sprouts of four types of edible amaranth, as amaranth has recently attracted interest due to its appreciable nutritional value. MTT assay conducted for the amaranth seeds and sprouts did not show any adverse effect on the viability of murine RAW 264.7 cells. As amaranth accumulates selenium, the sprouts were supplemented with this trace element (10 mg/L; 15 mg/L Se as sodium selenite) while growing. Selenium concentration in sprouts was observed to be significantly correlated with betacyanins content of the tested species. The amounts of Se and betacyanins in sprouts varied for various Amaranth species. In the present study, Amaranthus cruentus sprouts with the highest betacyanins (19.30 ± 0.57–28.85 ± 2.23 mg of amaranthin/100 g of fresh weight) and high total selenium (22.51 ± 1.57–1044.75 ± 73.08 μg/L in methanol extracts) content prevented NFκB translocation to the cell nucleus and subsequently exerted an anti-inflammatory effect by significant decreasing inflammatory interleukin 6 production (587.3 ± 34.2–710.0 ± 88.1 pg/mL) in the cell culture of activated RAW 264.7 macrophages (vs LPS control 1520 ± 114 pg/mL).Electronic supplementary materialThe online version of this article (doi:10.1007/s12011-015-0429-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Methodsmentioning

confidence: 99%

Selenium Supplementation of Amaranth Sprouts Influences Betacyanin Content and Improves Anti-Inflammatory Properties via NFκB in Murine RAW 264.7 Macrophages

Tyszka-Czochara

Paśko

Zagrodzki

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Microscopical lesions include renal tubular degeneration and necrosis. Kessell et al (33) observed acute renal failure to be associated with Amaranthus species, including A. retro exus ingestion by lambs.…”

Section: Aegopodium Podagraria Lmentioning

confidence: 99%

Plants Used in Podkarpackie Voivodeship (Poland) To Treat Urinary Diseases

Olas

Różański

Urbańska

et al. 2021

Preprint

View full text Add to dashboard Cite

Background This manuscript contains the results of Podkarpackie Voivodeship (Poland) ethnomedical studies on the treatment of urinary tract diseases using wild and cultivated plants. The study concerns plants mainly used for the supportive treatment of urinary tract infections, urolithiasis and benign prostatic hyperplasia. In this present study, we aim to collect and assess the ethnomedicinal potential of plants used in Podkarpackie Voivodeship (Poland) to treat urological diseases. Methods This article is based on interviews with fourteen recognized traditional healers (urban areas) and nine informants (rural areas) living in the south-eastern region of Poland - Podkarpackie Voivodeship. The survey took place between November 2019 and January 2021. For each plant mentioned in herbal remedies, polish name, part used, mode of preparation, and their properties, according to the healers and informants, were recorded. Results For the analysis, 123 species that belong to 43 families were selected. The most common families used to treat urinary diseases in Podkarpackie herbal medicine are the Compositae (18 species), Rosaceae and Apiaceae (11 species in each), Leguminosae (9 species), and Ericaceae (6 species). Of the species listed, Apium graveolens L., Arctium lappa L., Arctostaphylos uva-ursi (L.) Spreng., Elymus repens (L.) Gould, Juniperus communis L., Matricaria chamomilla L., Petroselinum crispum (Mill.) Fuss, Solidago virgaurea L., Urtica dioica L., and Viola tricolor L. were the most frequently mentioned. Most plants are used in multicomponent blends, which are given in the form of infusions or decoction. The described plants have mainly antiseptic, diuretic, spasmolytic and anti-inflammatory properties. Conclusions The results of the research described in this paper indicate that herbal treatment of urinary tract diseases is still used in Poland in the Podkarpackie Voivodeship. It is mainly used by people who do not want to use allopathic medicine, especially antibiotics. They are both inhabitants of large cities and villages. The latter often because of the multi-generational tradition, prefer self-healing.

show abstract

“…In one Australian report, a large number of animals (lambs) died after A. hybridus and A. retroflexus ingestion. The postmortem analysis showed bilaterally swollen kidneys with diffuse pale cortices strongly suggestive of acute toxic nephrosis [48]. The potentially valuable properties of Amaranthus greatly depend on its preparation before using.…”

Section: Plant Nephrotoxicitymentioning

confidence: 99%

Acute toxic kidney injury

et al. 2019

View full text Add to dashboard Cite

Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nephrotoxic substances, may be community acquired with ingestion or inhalation or nosocomial. Many nephrotoxic plants, animal poisons, medications, chemicals and illicit drugs can induce AKI by varying pathophysiological pathways. Moreover, the epidemiology of toxic AKI varies depending on country, regions within countries, socioeconomic status and health care facilities. In this review, we have selected nephrotoxic insults due to medication, plants, animal including snake venom toxicity, environmental, (agri)chemicals and also illicit drugs. We conclude with a section on diagnosis, clinical presentation and management of poisoning accompanied by various organ dysfunction and AKI.

show abstract

Acute renal failure associated withAmaranthusspecies ingestion by lambs

Cited by 12 publications

References 11 publications

Selenium Supplementation of Amaranth Sprouts Influences Betacyanin Content and Improves Anti-Inflammatory Properties via NFκB in Murine RAW 264.7 Macrophages

Selenium Supplementation of Amaranth Sprouts Influences Betacyanin Content and Improves Anti-Inflammatory Properties via NFκB in Murine RAW 264.7 Macrophages

Plants Used in Podkarpackie Voivodeship (Poland) To Treat Urinary Diseases

Acute toxic kidney injury

Contact Info

Product

Resources

About