Acute pure motor neuropathy with antibodies to gangliosides in a patient with multiple sclerosis

Simonetti, S.; Capello, Elisabetta

doi:10.1007/s004150050256

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…In the literature there are few cases of Guillain-Barré syndrome (GBS) occurring in patients with clinically definite MS [7]. In 2008, Sharma et al [8] described five cases of chronic inflammatory demyelinating polyneuropathy (CIDP) which developed in MS patients.…”

Section: Introductionmentioning

confidence: 99%

Development of Guillain-Barré syndrome in a patient with multiple sclerosis during treatment with glatiramer acetate

Motta

Gołba

Huć

et al. 2012

Neurologia i Neurochirurgia Polska

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Some observations suggest that in some patients with multiple sclerosis demyelination may affect the central and peripheral nervous systems at the same time. The influence of immunomodulatory therapy on peripheral nervous system damage in these patients is still unknown. We present a 43-year-old male patient with multiple sclerosis diagnosed at the age of 35 in whom flaccid tetraparesis with dysaesthesia preceded by paraesthesias of four limbs occurred one year after starting glatiramer acetate. The course of peripheral nervous system disease and results of cerebrospinal fluid examination and electromyography confirmed Guillain-Barré syndrome. Interfering in the immunological system, glatiramer acetate may have contributed to the development of the symptoms of Guillain-Barré syndrome in our patient. The final improvement of the patient's condition may have resulted not only from the applied treatment and the natural course of the disease, but may have also been associated with the discontinuation of glatiramer acetate.

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Section: Introductionmentioning

confidence: 99%

Development of Guillain-Barré syndrome in a patient with multiple sclerosis during treatment with glatiramer acetate

Motta

Gołba

Huć

et al. 2012

Neurologia i Neurochirurgia Polska

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Peripheral nerves are progressively involved in multiple sclerosis – A hypothesis from a pilot study of temperature sensitized electroneurographic screening

et al. 2009

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Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis

Greer

2013

Multiple Sclerosis International

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Central nervous system (CNS) myelin, the likely major target of autoimmune attack in multiple sclerosis (MS), contains a number of unique components that are potential targets of the attack. Two classes of molecules that are greatly enriched in CNS myelin compared to other parts of the body are certain types of proteolipids and glycolipids. Due to the hydrophobic nature of both of these classes of molecules, they present challenges for use in immunological assays and have therefore been somewhat neglected in studies of T-cell reactivity in MS compared to more soluble molecules such as the myelin basic proteins and the extracellular domain of myelin oligodendrocyte glycoprotein. This review firstly looks at the makeup of CNS myelin, with an emphasis on proteolipids and glycolipids. Next, a retrospective of what is known of T-cell reactivity directed against proteolipids and glycolipids in patients with MS is presented, and the implications of the findings are discussed. Finally, this review considers the question of what would be required to prove a definite role for autoreactivity against proteolipids and glycolipids in the pathogenesis of MS.

show abstract

Acute pure motor neuropathy with antibodies to gangliosides in a patient with multiple sclerosis

Cited by 3 publications

References 13 publications

Development of Guillain-Barré syndrome in a patient with multiple sclerosis during treatment with glatiramer acetate

Development of Guillain-Barré syndrome in a patient with multiple sclerosis during treatment with glatiramer acetate

Peripheral nerves are progressively involved in multiple sclerosis – A hypothesis from a pilot study of temperature sensitized electroneurographic screening

Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis

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