Peripheral nerves are progressively involved in multiple sclerosis – A hypothesis from a pilot study of temperature sensitized electroneurographic screening

Hidasi, Eszter; Diószeghy, Péter; Csépány, Tünde; Mechler, Ferenc; Bereczki, Dániel

doi:10.1016/j.mehy.2008.07.066

Cited by 7 publications

(14 citation statements)

References 21 publications

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“…Involvement of the PNS was proposed to be mild and progressive in MS patients, but no significant difference was shown at the beginning of the study [7]. Although this study was investigating the temperature effects on standard nerve conduction properties but not excitability, the results of the study regarding progressive peripheral nerve involvement in MS patients differ from the present study's results.…”

Section: Discussioncontrasting

confidence: 75%

Strength-Duration Time Constant in Peripheral Nerve: No Abnormality in Multiple Sclerosis

Genç¹,

Bek²,

Kaşikçi³

et al. 2012

Multiple Sclerosis International

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Objectives. To investigate the properties of the strength-duration time constant (SDTC) in multiple sclerosis (MS) patients. Methods. The SDTC and rheobase in 16 MS patients and 19 healthy controls were obtained following stimulation of the right median nerve at the wrist. Results. SDTC and rheobase values were 408.3 ± 60.0 μs and 4.0 ± 1.8 mA in MS patients, versus 408.0 ± 62.4 μs and 3.8 ± 2.1 mA in controls. The differences were not significant in SDTC or rheobase values between the patients and controls (P = 0.988 for SDTC and P = 0.722 for rheobase). Conclusion. Our study showed no abnormality in relapsing remitting MS patients in terms of SDTC, which gives some indirect information about peripheral Na+ channel function. This may indicate that alterations in the Na+ channel pattern in central nervous system (CNS) couldnot be shown in the peripheral nervous system (PNS) in the MS patients by SDTC. The opinion that MS can be a kind of channelopathy might be proven by performing other axonal excitability tests or SDTC in progressive forms of MS.

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Section: Discussioncontrasting

confidence: 75%

Strength-Duration Time Constant in Peripheral Nerve: No Abnormality in Multiple Sclerosis

Genç¹,

Bek²,

Kaşikçi³

et al. 2012

Multiple Sclerosis International

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“…At both examinations, a trend toward a difference in latency between PwMS and HC was observed but did not yield statistically significant differences 5 . There were no changes in latencies in HC and PwMS at baseline and after 3 years 5 …”

Section: Resultsmentioning

confidence: 87%

“…Similarly, Gartzen et al 4 did not find differences between the two groups in regard to latencies of the tibial and peroneal nerves, whereas Görgülü et al 51 found prolonged latencies in right peroneal and left median nerves in PwMS compared to HC. In a longitudinal study with 13 PwMS and 13 HC, Hidasi et al 5 examined the median nerves twice in PwMS and HC 3 years apart. At both examinations, a trend toward a difference in latency between PwMS and HC was observed but did not yield statistically significant differences 5 .…”

Section: Resultsmentioning

confidence: 99%

“…In a longitudinal study with 13 PwMS and 13 HC, Hidasi et al 5 examined the median nerves twice in PwMS and HC 3 years apart. At both examinations, a trend toward a difference in latency between PwMS and HC was observed but did not yield statistically significant differences 5 . There were no changes in latencies in HC and PwMS at baseline and after 3 years 5 …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, some studies have indicated that the peripheral nervous system (PNS) also becomes negatively affected by MS 3 . However, changes related to the PNS remain to be elucidated 4,5 . Several studies have shown that degeneration of CNS ultimately leads to impairment in neuromuscular function such as muscle strength, which contributes to deterioration of physical function 6 .…”

Section: Introductionmentioning

confidence: 99%

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Neurophysiological impairments in multiple sclerosis—Central and peripheral motor pathways

et al. 2020

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A systematic review of the literature was conducted comparing neurophysiological outcomes in persons with multiple sclerosis (PwMS) to healthy controls (HC), in studies of the central nervous system (CNS) function comprising motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) and in studies of the peripheral nervous system (PNS) function comprising electroneuronography (ENG) outcomes elicited by peripheral nerve stimulation. Studies comparing neuromuscular function, assessed during maximal voluntary contraction (MVC) of muscle, were included if they reported muscle strength along with muscle activation by use of electromyography (EMG) and/or interpolated twitch technique (ITT). Studies investigating CNS function showed prolonged central motor conduction times, asymmetry of nerve conduction motor pathways, and prolonged latencies in PwMS when compared to HC. Resting motor threshold, amplitude, and cortical silent periods showed conflicting results. CNS findings generally correlated with disabilities. Studies of PNS function showed near significant prolongation in motor latency of the median nerve, reduced nerve conduction velocities in the tibial and peroneal nerves, and decreased compound muscle action potential amplitudes of the tibial nerve in PwMS. ENG findings did not correlate with clinical severity of disabilities. Studies of neuromuscular function showed lower voluntary muscle activation and increased central fatigue in PwMS, whereas EMG showed divergent muscle activation (ie, EMG amplitude) during MVC. When comparing the existing literature on neurophysiological motor examinations in PwMS and HC, consistent and substantial impairments of CNS function were seen in PwMS, whereas impairments of the PNS were less pronounced and inconsistent. In addition, impairments in muscle activation were observed in PwMS.

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The latency distribution of motor evoked potentials in patients with multiple sclerosis

Firmin¹,

Müller²,

Rösler³

2012

Clinical Neurophysiology

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Peripheral nerves are progressively involved in multiple sclerosis – A hypothesis from a pilot study of temperature sensitized electroneurographic screening

Cited by 7 publications

References 21 publications

Strength-Duration Time Constant in Peripheral Nerve: No Abnormality in Multiple Sclerosis

Strength-Duration Time Constant in Peripheral Nerve: No Abnormality in Multiple Sclerosis

Neurophysiological impairments in multiple sclerosis—Central and peripheral motor pathways

The latency distribution of motor evoked potentials in patients with multiple sclerosis

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