Acute Pulmonary Edema Following Naloxone Reversal of High-dose Morphine Anesthesia

Apnéia na sala de recuperação pós-anestésica: relato de caso

“…Patients should be closely observed until reaching adequate SpO 2 with no need for breathing stimulations. Since there are major differences in individual responses to opioids, the use of antagonists (naloxone) or agonist-antagonists (nalbufine) should be evaluated in a case-by-case basis [15][16][17][18][19][20][21][22][23][24][25] . When deciding for their use, the scheme of fractional naloxone or nalbufine doses proposed by Bailey 24 seems to be adequate and safe.…”

Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine

“…Peripheral vasoconstriction can lead to fluid shifting from the systemic venous to the pulmonary circulation. 13 These differences between naloxone and nalbuphine may be related to the ways in which each reacts with the different opiate receptors. Specifically, most opioids stimulate mu receptors to a large degree, and kappa receptors to a lesser degree.…”

Naloxoninduziertes Lungenödem

“…Im Jahr 1977 wurde zum ersten Mal von der Entwicklung eines Lungenödems nach Naloxongabe berichtet [1]. Hierbei kommt es zu einer fulminanten Verschlechterung des alveolären Gasaustausches.…”

“…Außer-dem sind verschiedenste Medikamente angeschuldigt worden, ein postoperatives NCPE auszulösen [10]. Unter anderen ist Naloxon mit der Entstehung eines Lungenödems assoziiert worden, erstmals 1977 in der Literatur von Flacke et al [1] beschrieben.…”