1990
DOI: 10.1007/bf03005476
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Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine

Abstract: Reversal of opioid effects by naloxone (NX

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Cited by 43 publications
(17 citation statements)
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“…In the patient with known or suspected opioid overdose with respiratory depression who is not in cardiac arrest, ventilation should be assisted by a bag mask, [232][233][234][235][236][237][238] followed by administration of naloxone and placement of an advanced airway if there is no response to naloxone (Class I, LOE A).…”
Section: Opioid Toxicitymentioning
confidence: 99%
“…In the patient with known or suspected opioid overdose with respiratory depression who is not in cardiac arrest, ventilation should be assisted by a bag mask, [232][233][234][235][236][237][238] followed by administration of naloxone and placement of an advanced airway if there is no response to naloxone (Class I, LOE A).…”
Section: Opioid Toxicitymentioning
confidence: 99%
“…Ventilation before administration of naloxone appears to reduce these adverse effects. 411 Intramuscular administration of naloxone may lower the risk by slowing the onset of drug effect.…”
Section: Treatmentmentioning
confidence: 99%
“…This theory is supported by numerous anecdotal human cases, as well as animal evidence in which opioid-naïve canines intoxicated on fentanyl had significant increases in catecholamine concentrations after naloxone infusion. 7,8 This theory is also supported by a series of opioid-naïve patients given opioids while undergoing surgery who developed opioid-related ALI after the administration of naloxone. 9 …”
Section: Discussionmentioning
confidence: 92%