Acute Pulmonary Complications in Systemic Lupus Erythematosus: Immunofluorescence and Light Microscopic Study

Pertschuk, Louis P.; Moccia, Louis F.; Rosen, Yale; Lyons, Harold A.; Marino, Catherine; Rashford, Allen A.; Wollschlager, Christine M.

doi:10.1093/ajcp/68.5.553

Cited by 73 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The effectiveness of plasmapheresis in patients with acute lupus pneumonia or with alveolar haemorrhage (AH) suggests the importance of autoantibodies in the pathophysiology of this pulmonary damage [15,16]; • the CIC deposits in human SLE prove their implication in the disease. Immunoglobulins with or without complement have been found in the alveolar walls and capillaries of patients with diffuse infiltrating pneumonia [14,17]. This hypothesis is reinforced by the presence of DNA, IgG and C3 on immunofluorescent microscopy of lung tissue in patients with acute lupus [18].…”

Section: Pathogenesis Of Lupusmentioning

confidence: 98%

Respiratory involvement in systemic lupus erythematosus

Carmier

Marchand-Adam

Diot

et al. 2010

Revue des Maladies Respiratoires

View full text Add to dashboard Cite

Section: Pathogenesis Of Lupusmentioning

confidence: 98%

Respiratory involvement in systemic lupus erythematosus

Carmier

Marchand-Adam

Diot

et al. 2010

Revue des Maladies Respiratoires

View full text Add to dashboard Cite

“…In pleural biopsy specimens from 3 patients with drug-induced lupus pleural effusions [90] and autopsy pleural specimens from patients with SLE [91], a specific immunofluorescent pattern has been observed, characterized by diffuse and speckled staining of cell nuclei with anti-IgG, anti-IgM or anti-C3 [90]. Thoracoscopy reveals nodules on the visceral pleura, and immunofluorescence of biopsy samples of these nodules demonstrated immunoglobulin deposits [63, 92].…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Pleural Involvement in Systemic Autoimmune Disorders

2008

View full text Add to dashboard Cite

Systemic autoimmune diseases, a heterogeneous group of immunologically mediated inflammatory disorders including multiorgan involvement, can affect the pleura with various frequencies, either as a single presenting feature or as part of multisystem involvement. Rheumatoid arthritis and systemic lupus erythematosus represent the most common immunological diseases that affect the pleural cavity; however, there is considerable variation regarding the reported prevalence, natural history and prognosis of pleural involvement in both conditions. The definition of pleural disease in the remaining systemic autoimmune disorders is unquestionably imprecise and assumptive, since it is risky to support premises based on single case reports or retrospective data from very small series. In this article, we will review the manifestations of pleural disease caused by rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis/dermatomyositis, mixed connective tissue disease, ankylosing spondylitis, Sjögren’s syndrome and Wegener’s granulomatosis.

show abstract

“…High preval ences of circulating and tissue-bound im mune complexes and/or antinuclear an tibodies were reported [26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Lung-Reactive Antibodies in Sera of Patients with Farmer’s Lung Disease

Dewair¹,

Baur²,

Fruhmann³

1987

Respiration

View full text Add to dashboard Cite

Lung-reactive antibodies were detected in sera of patients with farmer’s lung disease and in sera of healthy persons. A solid-phase radioimmunoassay was adapted for measurement of titers of human antibodies to sodium-dodecyl-sulfate-solubilized lung proteins. The titers of antilung antibodies in patients sera were 2–5 times as much as those of healthy persons. Using the immunoblotting technique, antibodies to individual lung polypeptides could be detected. Although the specificity patterns of antibodies to lung polypeptides differed from one serum to another, patients sera contained, in general, antibodies to larger numbers of lung polypeptides as compared to sera of healthy persons. The relationship between antilung antibodies and hypersensitivity pneumonitis is discussed.

show abstract

Acute Pulmonary Complications in Systemic Lupus Erythematosus: Immunofluorescence and Light Microscopic Study

Cited by 73 publications

References 5 publications

Respiratory involvement in systemic lupus erythematosus

Respiratory involvement in systemic lupus erythematosus

Pleural Involvement in Systemic Autoimmune Disorders

Lung-Reactive Antibodies in Sera of Patients with Farmer’s Lung Disease

Contact Info

Product

Resources

About