Acute preclinical toxicity study ofZanthoxylum naranjillo extract

Abstract

In previous studies, Zanthoxylum naranjillo hexane crude extract revealed marked analgesic and antimalarial activities. This paper reports an investigation of preclinical toxicity in acute phase ( 24 h and 15 days with repeated doses ) in which the action of different extract doses ( 15, 150 and 450 mg/kg ) was evaluated. Wistar rats weighing 300 ± 15 g were submitted to toxicological evaluation of clinical chemical, haematological and haemostatic blood parameters including evaluation of liver, pancreas, kidneys, bile ducts, heart, serum lipids, bonc marrow, haematological and haemostatic systems. The initial results showed an alteration of albumin and alkaline phosphatase at some of the doses tested, but without suggesting hepatic or biliary involvement. Copyright © 1998 John Wiley & Sons, Ltd.

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

“…Islam et al (2001) verified that etheric extracts from the bark of Z. rhesta are toxic to Artemia salina which, on the other hand, does not suffer toxic action from chlorophormic extracts of Z. budrunga; Ju et al (2001) showed that Z. americanum presented substances, as dipetaline, alloxanthoxyletin e sesamin, that inhibit the DNA synthesis in HL-60 cells; Rodrigues et al (1998) reported the hexane extracts of Z. naranjillo induced alterations in albumin and alkaline phosphatase levels in mice, without liver or biliary alterations, which suggests a possible absence of clinical toxicity. From these studies, it is possible to confirm several potential therapeutical uses of plants from the genus Zanthoxylum.…”