A 90 day repeated oral toxicity study on plantamajoside concentrate from <i>Plantago asiatica</i>

Park, Byung Gyu; Lee, Hyun Sun; Jung, Sung Hoon; Hong, Chung Oui; Won, Hye Jin; Park, Ho-Young; Ryu, Yung Sun; Lee, Sung Joon; Kim, Kyoung Heon; Park, Kuen Woo; Lee, Kwang Won

doi:10.1002/ptr.2217

Cited by 18 publications

(12 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous report discussed the isolations of plantamajoside, plantagin and aucubin from P. asiatica, as well as the various biological properties of these compounds, including antibacterial, antiallergic, antiinflammatory, antioxidative and lipoxygenase inhibitory activity (Nishibe, 2002). In our previous study, plantamajoside was isolated, and a 90 day repeated oral toxicity test was performed in rats, confirming its safety at a dose of 2000 mg/kg (Park et al, 2007). The purpose of the present study was to investigate the genotoxicity of plantamajoside, to further confirm its safety for use as a phytochemical agent in health products.…”

Section: Introductionmentioning

confidence: 69%

Cytogenetic investigation of chromosomal aberrations in cells treated with plantamajoside from Plantago asiatica

Koo

Jung

Yang

et al. 2009

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Plantago asiatica is a member of the Plantaginaceae family, and is widely distributed in East Asia. In our previous work, a single active compound, plantamajoside was isolated and confirmed to have glycation inhibitory activity, and did not possess toxicity during a 90 day repeated oral toxicity test in rats. In the present study, a chromosomal aberration test was performed to investigate the genotoxicity of plantamajoside. From the results of the cytotoxicity test, plantamajoside proved to be less toxic when it was treated combined with S9 cell fractions. However, there was a significant increase in structural aberrations during the short-term treatment of plantamajoside at its highest dose (5000 microg/mL) even when combined with S9. This seems to have been a natural phenomenon due to the very high dose of plantamajoside that was used. However, to confirm the safety of plantamajoside for its potential use as a phytochemical agent in health products, additional mutagenicity tests are necessary.

show abstract

Section: Introductionmentioning

confidence: 69%

Cytogenetic investigation of chromosomal aberrations in cells treated with plantamajoside from Plantago asiatica

Koo

Jung

Yang

et al. 2009

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…such as ursolic acid, plantamajoside R, aceteoside R and plantagonin have been shown to have both an antioxidant and antiinflammatory effect [6]. Numerous studies have shown that Plantago species had a high phenolic content and antioxidant activity [39][40][41][42][43][44][45][46][47][48]. There are few studies carried out in Turkey showing high antioxidant activity for P. lanceolata [40][41][42][43][44][45][46][47][48][49][50] and P. major [51,52].…”

Section: Discussionmentioning

confidence: 99%

Evalution of Antioxidant Activity of Various Herbal Folk Medicines

Miser-Salihoglu

Akaydın²,

Caliskan-Can³

et al. 2013

J Nutr Food Sci

View full text Add to dashboard Cite

The leaves of some plants are flamed and used to dress injured skin, to stimulate healing and to ward off infection. This study aims to determine antioxidant activities of Plantago lanceolata L., Plantago major L. ssp. major, Rubus hirtus Waldst& Kit., Sambucus ebulus L., Morus alba L. and Hedera helix L., which grown in Düzce and its surroundings and are used for anti-inflammatory purposes, and especially for wound-healing. The total phenolic compound of these plants was also evaluated. In order to determine the antioxidant compounds and antioxidant capacity of these plants, different in vitro methods. Resulting from our study, while P. lanceolata, R. hirtus, S. ebulus and P.major ssp. major had similarities in terms of phenolic compounds content, M. alba and H. helix were found to have relatively low content of phenolic compounds. In general, Plantago species and R. hirtus showed high antioxidant activities.

show abstract

“…Tissues were processed, sectioned, and stained, with hematoxylin and eosin, and were examined by a pathologist. [6–9]…”

Section: Methodsmentioning

confidence: 99%

Safety profile of a polyherbal formulation (Gynocare capsules) in female rats by subchronic oral toxicity study

2012

View full text Add to dashboard Cite

Gynocare capsules, is a polyherbal formulation, are used as uterine tonic and for treating gynaecological ailments like infertility, leucorrhea, and menstrual disorders. The formulation contains ingredients of herbal origin, such as, extracts of Ashoka, Vasaka, Durva, Chandan, Musk, and so on. It was evaluated for its safety at the therapeutic dose level by a repeated dose oral toxicity study in albino Wistar rats. The herbal formulation was administered orally at a therapeutic dose of 100 mg/kg/day, for 90 days. All animals were monitored daily for their health status and signs of abnormalities. The body weight, water consumption, and food intake were measured once weekly. At the end of the experimental period, various hematological and biochemical parameters were estimated and histopathologies of selected organs were conducted. The study resulted from the long-term oral administration of Gynocare capsules (100 mg/kg), did not cause any relevant signs of toxicity nor significant changes in the physical, hematological and biochemical parameters. However, statistically significant differences were seen in the relative organ weights of adrenal gland, ovary, and serum creatinine levels. The reduction in ovary weight revealed the possibility of the drug targeting the ovary. Moreover, no pathological features were identified in the treated group as monitored by the histopathological analysis of the internal organs. The study established that Gynocare capsules at the dose given (100 mg/kg) did not induce any remarkable or significant toxic effects, indicating that it was safe in rats following oral administration for 90 consecutive days.

show abstract

A 90 day repeated oral toxicity study on plantamajoside concentrate from Plantago asiatica

Cited by 18 publications

References 13 publications

Cytogenetic investigation of chromosomal aberrations in cells treated with plantamajoside from Plantago asiatica

Cytogenetic investigation of chromosomal aberrations in cells treated with plantamajoside from Plantago asiatica

Evalution of Antioxidant Activity of Various Herbal Folk Medicines

Safety profile of a polyherbal formulation (Gynocare capsules) in female rats by subchronic oral toxicity study

Contact Info

Product

Resources

About