Acute posterior vitreous detachment: the predictive value of vitreous pigment and symptomatology

Tanner, Vaughn; Harle, Deacon E.; Tan, Jannes F; Foote, B; Williamson, Tom H.; Chignell, A H

doi:10.1016/s0002-9394(01)00846-7

Cited by 15 publications

(25 citation statements)

References 2 publications

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“…We excluded only those eyes with identified, recurrent disease within 4 months of presentation. In spite of the different selection criteria there are certain qualitative similarities between this study and that of Tanner et al 13 . In both studies field or visual loss was the most frequently reported symptom, with asymptomatic RRD being relatively uncommon.…”

Section: Discussionsupporting

confidence: 61%

“…Tanner et al . reviewed the symptoms in a consecutive series of patients presenting with primary retinal detachment but excluded those eyes that had undergone previous intraocular surgery, including cataract surgery 13 . They also excluded patients who had undergone retinopexy or previous retinal detachment surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Not all patients presenting with RRD report premonitory symptoms, and unfortunately many of the symptoms associated with retinal detachment are not specific and overlap with both ageing changes in the vitreous as well as posterior vitreous detachment (PVD) and retinal breaks 11–13 . However, the opportunity of being able to examine such patients does provide the occasion to educate the patient about the risks of vitreoretinal disease, as well as to develop a strategy should the symptoms change 14 .…”

Section: Introductionmentioning

confidence: 99%

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Analysis of symptoms associated with rhegmatogenous retinal detachments

Polkinghorne

Craig

2004

Clinical Exper Ophthalmology

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of symptoms associated with rhegmatogenous retinal detachments

Polkinghorne

Craig

2004

Clinical Exper Ophthalmology

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“…The classical symptomatology of an acute posterior vitreous detachment is that of sudden onset of flashes and/or floaters, although their predictive value in relation to a retinal break is not conclusive. 5 Others have found that these symptoms in association with a subjective decrease in vision to be more predictive. 6 Examination of the retina in all patients who present with an acute posterior vitreous detachment should be thorough and include the anterior retina.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic effectiveness of noncontact slitlamp examination in the identification of retinal tears

Natkunarajah

Goldsmith

Goble

2003

Eye

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Purpose To compare the diagnostic accuracy of noncontact slitlamp examination with indirect ophthalmoscopy and scleral depression, in the identification of retinal tears. Methods A prospective study was performed using 17 patients who were referred with retinal tears. All were initially examined at the slitlamp with a hand-held Volk (noncontact) lens. The same observer then carried out indirect ophthalmoscopy with scleral indentation.Results In 17 eyes a total of 18 acute retinal u-tears were found. A total of 16 tears were picked up at the initial examination at the slitlamp (89%), while two were missed (11%). Conclusions Indirect ophthalmoscopy with scleral depression is the 'gold standard' for the identification of peripheral retinal tears. This small study has shown that although the majority of these can be picked up by the use of a noncontact lens at the slitlamp, 11% were missed using this technique.

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“…The control group were drawn from patients who had attended the ophthalmology department at Addenbrooke's hospital for reasons other than retinal detachment and who were over the age of 65 years, such that the majority would have already experienced a PVD but without associated retinal detachment. Approximately one‐third of the adult population will never undergo a PVD [Foos, ; Snead et al., ; Sebag, ], but for those that do, the average age for completion (with or without an associated retinal tear) is 65 years [Tanner et al., ]. The control group were therefore drawn from patients who had undergone a full vitreous and fundal examination and who were over the age of 65 years.…”

Section: Methodsmentioning

confidence: 99%

Deep Intronic Sequence Variants inCOL2A1Affect the Alternative Splicing Efficiency of Exon 2, and May Confer a Risk for Rhegmatogenous Retinal Detachment

et al. 2016

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(2016). Deep intronic sequence variants in COL2A1 affect the alternative splicing efficiency of Exon 2, and may confer a risk for rhegmatogenous retinal detachment. Human Mutation, 37(10), 1085-1096. DOI: 10.1002/humu.23050 General rightsCopyright and moral rights for the publications made accessible in Discovery Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from Discovery Research Portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain.• You may freely distribute the URL identifying the publication in the public portal. Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Stickler syndrome which has a high risk of retinal detachment and failure of the vitreous to develop normally. Exon 2 of COL2A1 is alternatively spliced, expressed in the eye but not in mature cartilage and encodes a region that binds growth factors TGFβ1 and BMP-2. We investigated how both a mutation in intron 2 and a normal variant allele altered the efficiency of COL2A1 exon 2 splicing and how the latter may act as a predisposing risk factor for the occurrence of rhegmatogenous retinal detachment (RRD) in the general population. Using both amplification of illegitimate transcripts and allele specific minigenes expressed in cultured cells, we demonstrate variability in exon 2 inclusion not only between different control individuals, but also between different COL2A1 alleles. We also identify possible trans-acting factors that bind to allele specific RNA sequences, and investigate the effect of both knockdown and over expression of these factors on exon 2 splicing efficiency. Finally, using a specific cohort of patients with RRD and a control population, we demonstrate a significant difference in the frequency of the COL2A1 intronic variant rs1635532 between the two groups.

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Acute posterior vitreous detachment: the predictive value of vitreous pigment and symptomatology

Cited by 15 publications

References 2 publications

Analysis of symptoms associated with rhegmatogenous retinal detachments

Analysis of symptoms associated with rhegmatogenous retinal detachments

Diagnostic effectiveness of noncontact slitlamp examination in the identification of retinal tears

Deep Intronic Sequence Variants inCOL2A1Affect the Alternative Splicing Efficiency of Exon 2, and May Confer a Risk for Rhegmatogenous Retinal Detachment

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