Acute Polyuric Renal Failure After Aspirin Intoxication

Rupp, Dennis; Seaton, Robert; Wiegmann, Thomas

doi:10.1001/archinte.1983.00350060169026

Cited by 15 publications

(3 citation statements)

References 12 publications

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“…Several mechanisms have been proposed to be responsible for acute kidney injury (AKI). Insensible fluid loss because of increase in body temperature along with gastrointestinal losses from emesis have a potential to results in severe volume depletion, causing renal hypoperfusion 3 . In addition, salicylate‐induced nephrotoxicity can manifest through acute tubular necrosis, acute interstitial nephritis, papillary necrosis and proximal tubular dysfunction 4‐6 .…”

Section: Introductionmentioning

confidence: 99%

“…Insensible fluid loss because of increase in body temperature along with gastrointestinal losses from emesis have a potential to results in severe volume depletion, causing renal hypoperfusion. 3 In addition, salicylate-induced nephrotoxicity can manifest through acute tubular necrosis, acute interstitial nephritis, papillary necrosis and proximal tubular dysfunction. [4][5][6] Although AKI has been reported as a complication of salicylate intoxication, studies in epidemiology and impact of AKI on outcomes in salicylate intoxication have been limited.…”

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confidence: 99%

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Acute kidney injury among salicylate intoxication hospitalisations in the United States

et al. 2020

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Background This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilisation in patients hospitalised because of salicylate intoxication in the United States. Methods Hospitalised patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End‐stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clinical characteristics, in‐hospital treatment, outcomes and resource utilisation were compared between patients with and without AKI. Results A total of 13 787 eligible hospital admissions were included in the analysis. AKI occurred in 1279 (9.3%) admissions. Older age, male sex, more recent year of hospitalisation, anaemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in‐hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay and hospitalisation cost were higher in AKI patients. Conclusion Approximately one tenth of salicylate intoxication patients developed AKI during hospitalisation. AKI was associated with higher morbidity, mortality and resource utilisations.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Acute kidney injury among salicylate intoxication hospitalisations in the United States

et al. 2020

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“…Insensible fluid loss due to increase in body temperature along with gastrointestinal losses from emesis have a potential to results in severe volume depletion, up to 6 L in some cases, causing renal hypoperfusion. 4 In addition, salicylate-induced nephrotoxicity can manifest through acute tubular necrosis, acute interstitial nephritis, papillary necrosis, and proximal tubular dysfunction. [5][6][7] Although AKI has been reported as a complication of salicylate intoxication, the epidemiology and impact of AKI on outcomes has been limited.…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury among Salicylate Intoxication Hospitalizations in the United States

Petnak

Kaewput

Qureshi

et al. 2020

Preprint

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Background: This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilization in patients hospitalized due to salicylate intoxication in the United States. Methods: Hospitalized patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End-stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clinical characteristics, in-hospital treatment, outcomes and resource utilization were compared between patients with and without AKI. Results: A total of 13,787 eligible hospital admissions were included in the analysis. AKI occurred in 1,279 (9.3%) admissions. Older age, male sex, more recent year of hospitalization, anemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis, and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in-hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay, and hospitalization cost were higher in AKI patients. Conclusion: Approximately one tenth of salicylate intoxication patients developed AKI during hospitalization. AKI was associated with higher morbidity, mortality, and resource utilizations. What's already known about this topic? Acute kidney injury has been reported as a complication of salicylate intoxication. What does this article add? • Acute kidney injury occurred in about 9% of hospitalization for salicylate intoxication. • Several clinical characteristics were identified as risk factors for acute kidney injury. • Acute kidney injury was associated with higher morbidity, mortality, and resource utilization.

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Renal Failure Caused by Chemicals, Foods, Plants, Animal Venoms, and Misuse of Drugs

1990

Arch Intern Med

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Acute Polyuric Renal Failure After Aspirin Intoxication

Cited by 15 publications

References 12 publications

Acute kidney injury among salicylate intoxication hospitalisations in the United States

Acute kidney injury among salicylate intoxication hospitalisations in the United States

Acute Kidney Injury among Salicylate Intoxication Hospitalizations in the United States

Renal Failure Caused by Chemicals, Foods, Plants, Animal Venoms, and Misuse of Drugs

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