Acute phenolphthalein ingestion in children A retrospective review

Mrvos, Rita; Swanson-Biearman, Brenda; Dean, Bonnie S.; Krenzelok, Edward P.

doi:10.1016/0891-5245(91)90025-l

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2003

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“…In 1 study of 204 cases of phenolphthalein-containing laxative ingestion by children ≤5 years of age, no children had symptoms that persisted >24 hours and no skin sloughing or blisters was reported. 3 In contrast to this, the mean duration of diarrhea in our patients was 28 hours, and 50% had a duration of diarrheal symptoms >24 hours, with 11% developing significant dermal injury.…”

Section: Discussionmentioning

confidence: 74%

“…2 In the acute setting, this was regarded as low risk and appropriate for home management in the vast majority of cases. 3 The arrival of a new formulation for these laxatives did not immediately prompt concern or suggestion that this belief needed to be reconsidered. New formulations of familiar products may have similar therapeutic profiles but produce significantly different adverse effects.…”

Section: Discussionmentioning

confidence: 99%

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