Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals

Acute phase response in Chinese soft-shelled turtle (Trionyx sinensis) with Aeromonas hydrophila infection

“…Level of C3 (a moderate APP) can increase 2-to 10-fold in the course of mammalian APR. In this study, turtle C3 mRNA was upregulated about 5.8-fold at 2 d in the infected liver, striking similar to that in mammals (human and mouse), and zebrafish in which C3 mRNA also increased 4.3-fold after Aeromonas salmonicida (a Gram-negative bacterium) infection (Lin et al, 2007). Our results demonstrate that the turtle C3 may play an essential role in antiinfection as in other species.…”

“…While the aa insertion is present in horse and cattle SAA. Human and mouse SAA4 also contain the aa insertion which is a characteristic of constitutive SAAs (Lin et al, 2007). The length of turtle SAA protein (127 aa) is similar to those of trout, zebrafish and pufferfish Tetraodon (121 aa) and carp (123 aa) (Rebl et al, 2009).…”

“…SAA homologs have been identified in all vertebrates investigated and are highly conserved (Uhlar and Whitehead, 1999). In recent years, SAA homologs have also been identified and characterized from some fish, such as arctic char (Salvelinus alpinus), common carp (Cyprinus carpio), Atlantic salmon (Salmo salar), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) (Jensen et al, 1997;Fujiki et al, 2000;Jorgensen et al, 2000;Lin et al, 2007;Rebl et al, 2009). Although a tuatara (Sphenodon punctatus) SAA homologue in reptile (AAM46103) has been cloned, no report for reptilian APP has been found yet.…”

Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data

“…Aeromonas salmonicida and Staphylococcus aureus (1344 fold and 51 fold, respectively) (Lin et al, 2007). Although increases in LECT2 expression were found as a result of confinement at 8 h and 168 h, these increases were no more than 2 fold in magnitude.…”

“…Two other less well characterised genes selected for analysis were LECT2 and DRTP1. Expression of the LECT2 gene has been reported to increase markedly during the acute phase response in zebrafish (Danio rerio) (Lin et al, 2007) while the DRTP1 gene has been shown to be differentially regulated during the acute phase response in salmon (Martin et al, 2006) and trout Gerwick et al, 2007). The induction of DRTP1, in common with other acute phase proteins, has NF-κΒ and C/EBPβ as important transcription factors involved in its induction (Talbot et al, 2008).…”