Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data

Tissue-specific molecular immune response to lipopolysaccharide challenge in emaciated anadromous Arctic charr

“…The increased liver SAA expression seen in the control fasted fish at 96 h postinjection supports previous studies showing that fasted fish show a heightened acute phase response (Martin et al, 2010). Although acute phase proteins are synthesized predominantly in the liver (Talbot et al, 2009), our results show SAA expression profile to be similar in the spleen of fed charr in response to LPS stimulation. This is not surprising since recent studies have provided evidence of extrahepatic synthesis and cellular expression of APPs (Colten, 1992;Goetz et al, 2004;SaranyaRevathy et al, 2012).…”

“…The liver plays an important role in intermediary metabolism and, therefore, may be particularly sensitive to changes in nutritional status of the animal. The liver is also a major site of acute phase proteins (APPs) synthesis, which is a key component of the innate immune response (SaranyaRevathy et al, 2012;Talbot et al, 2009). Serum amyloid protein A (SAA) is a major APP and an effector of innate immunity in all vertebrates, including fish (Steel and Whitehead, 1994;Talbot et al, 2009).…”

“…The liver is also a major site of acute phase proteins (APPs) synthesis, which is a key component of the innate immune response (SaranyaRevathy et al, 2012;Talbot et al, 2009). Serum amyloid protein A (SAA) is a major APP and an effector of innate immunity in all vertebrates, including fish (Steel and Whitehead, 1994;Talbot et al, 2009). Recently, we demonstrated that trout hepatocytes can mount an innate immune response to lipopolysaccharide (LPS) stimulation, suggesting a role for this tissue in the inflammatory response, including upregulation of IL-1b, IL-8 and SAA (Philip et al, 2012).…”

Patterns of Piscirickettsia salmonis load in susceptible and resistant families of Salmo salar

“…Out of DE genes, all showed increased gene expression levels in the susceptible group, except for the c-type lysozyme (LysC). Recent studies proved that this gene has a protective function towards bacterial infections, and it is expressed particularly in macrophages [15]. The gene with the highest fold-change was the Haptoglobin (Fold change: 18.87), whose expression is expected to be more related to acute stress and general inflammatory response [15].…”

Identification of α1-antitrypsin as a positive acute phase protein in ayu (Plecoglossus altivelis) associated with Listonella anguillarum infection

“…More recently, AAT and antithrombin III were identified as major serpins of rainbow trout (Oncorhynchus mykiss) and carp (Cyprinus carpio) in blood plasma [12]. During the acute phase response, the anti-trypsin activity and AAT-like protein content were all down-regulated in Atlantic cod (Gadus morhua) and rainbow trout [13,14]. However, AAT gene expression following infection in ayu fish has not been well described.…”