Acute Phase Proteins

Güleç, Güliz Uyar; Turgut, Yaşar Barış; Turğut, Mehmet

doi:10.1016/b978-0-12-818731-9.00089-6

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…Thus, we tested the expression of acute phase proteins and inflammatory factors and cytokines in kidney, heart and liver tissue at 1 and 3 days after stroke. Acute phase proteins are a class of proteins whose concentration dramatically increases, or increases in the circulation in response to stimulation by pro-inflammatory cytokines ( Güleç et al, 2022 ). IL-6 is the major inducer for hepatic secretion of acute phase proteins while IL-1β, TNFα and interferon gamma (IFN-γ) are other cytokines that mediate acute phase response ( Güleç et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Acute phase proteins are a class of proteins whose concentration dramatically increases, or increases in the circulation in response to stimulation by pro-inflammatory cytokines ( Güleç et al, 2022 ). IL-6 is the major inducer for hepatic secretion of acute phase proteins while IL-1β, TNFα and interferon gamma (IFN-γ) are other cytokines that mediate acute phase response ( Güleç et al, 2022 ). In this study, we report for the first time that stroke in T2DM mice induces earlier and higher inflammatory factor, cytokine, and acute phase response protein expression such as SAA, NLRP3, IL-1β, IL-6, TNFα, and TLR4 in the liver compared to heart and kidney.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic effects of CD133 + Exosomes on liver function after stroke in type 2 diabetic mice

et al. 2023

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Background and purposeNon-alcoholic fatty liver disease (NAFLD) is known to adversely affect stroke recovery. However, few studies investigate how stroke elicits liver dysfunction, particularly, how stroke in type 2 diabetes mellitus (T2DM) exacerbates progression of NAFLD. In this study, we test whether exosomes harvested from human umbilical cord blood (HUCBC) derived CD133 + cells (CD133 + Exo) improves neuro-cognitive outcome as well as reduces liver dysfunction in T2DM female mice.MethodsFemale, adult non-DM and T2DM mice subjected to stroke presence or absence were considered. T2DM-stroke mice were randomly assigned to receive PBS or Exosome treatment group. CD133 + Exo (20 μg/200 μl PBS, i.v.) was administered once at 3 days after stroke. Evaluation of neurological (mNSS, adhesive removal test) and cognitive function [novel object recognition (NOR) test, odor test] was performed. Mice were sacrificed at 28 days after stroke and brain, liver, and serum were harvested.ResultsStroke induces severe and significant short-term and long-term neurological and cognitive deficits which were worse in T2DM mice compared to non-DM mice. CD133 + Exo treatment of T2DM-stroke mice significantly improved neurological function and cognitive outcome indicated by improved discrimination index in the NOR and odor tests compared to control T2DM-stroke mice. CD133 + Exo treatment of T2DM stroke significantly increased vascular and white matter/axon remodeling in the ischemic brain compared to T2DM-stroke mice. However, there were no differences in the lesion volume between non-DM stroke, T2DM-stroke and CD133 + Exo treated T2DM-stroke mice. In T2DM mice, stroke induced earlier and higher TLR4, NLRP3, and cytokine expression (SAA, IL1β, IL6, TNFα) in the liver compared to heart and kidney, as measured by Western blot. T2DM-stroke mice exhibited worse NAFLD progression with increased liver steatosis, hepatocellular ballooning, fibrosis, serum ALT activity, and higher NAFLD Activity Score compared to T2DM mice and non-DM-stroke mice, while CD133 + Exo treatment significantly attenuated the progression of NAFLD in T2DM stroke mice.ConclusionTreatment of female T2DM-stroke mice with CD133 + Exo significantly reduces the progression of NAFLD/NASH and improves neurological and cognitive function compared to control T2DM-stroke mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of CD133 + Exosomes on liver function after stroke in type 2 diabetic mice

et al. 2023

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“…Increased levels of HP have been observed in inflammatory processes, and it is considered an acute phase protein. In addition, HP is involved in the innate and acquired immune systems, playing a regulatory role in various stages of cellular and humoral immunity and in the release of cytokines [ 90 ]. This protein has recently been linked to neurodegenerative disorders such as AD and mild cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Targets Linked to the Cardiovascular/Alzheimer’s Axis through Bioinformatics Approaches

et al. 2022

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The identification of common targets in Alzheimer’s disease (AD) and cardiovascular disease (CVD) in recent years makes the study of the CVD/AD axis a research topic of great interest. Besides aging, other links between CVD and AD have been described, suggesting the existence of common molecular mechanisms. Our study aimed to identify common targets in the CVD/AD axis. For this purpose, genomic data from calcified and healthy femoral artery samples were used to identify differentially expressed genes (DEGs), which were used to generate a protein–protein interaction network, where a module related to AD was identified. This module was enriched with the functionally closest proteins and analyzed using different centrality algorithms to determine the main targets in the CVD/AD axis. Validation was performed by proteomic and data mining analyses. The proteins identified with an important role in both pathologies were apolipoprotein E and haptoglobin as DEGs, with a fold change about +2 and −2, in calcified femoral artery vs healthy artery, respectively, and clusterin and alpha-2-macroglobulin as close interactors that matched in our proteomic analysis. However, further studies are needed to elucidate the specific role of these proteins, and to evaluate its function as biomarkers or therapeutic targets.

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Acute Phase Proteins

Cited by 2 publications

References 40 publications

Therapeutic effects of CD133 + Exosomes on liver function after stroke in type 2 diabetic mice

Therapeutic effects of CD133 + Exosomes on liver function after stroke in type 2 diabetic mice

Identification of Potential Targets Linked to the Cardiovascular/Alzheimer’s Axis through Bioinformatics Approaches

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