Acute‐Phase Proteins, Oxidative Stress and Enzyme Activities of Blood Serum and Peritoneal Fluid in Cattle with Abomasal Displacement

Abstract

Background Blood serum and peritoneal fluid acute‐phase proteins, oxidative stress indicators, and some enzymes could be used for evaluation of abomasal tissue damage because of displacement in displaced abomasum (DA) cases. Objectives The aim of this study was to investigate the concentrations of acute‐phase proteins, oxidative stress indicators, and activities of enzymes in blood serum and peritoneal fluid in cattle with right displaced abomasum (RDA) and left displaced abomasum (LDA) and in healthy cows. Animals A total of 60 Holstein Friesian cows in early lactation were used, 31 with left and 9 with right displaced abomasum without volvulus diagnosis and no other postpartum disease, and 20 healthy cows as a control. Materials and Methods DA diagnosis in dairy cows consisted of physical examination, laboratory, and specific DA tests. Acute‐phase proteins, oxidative stress indicators, and enzyme activities were measured in blood serum and peritoneal fluid. Results In the RDA group, serum haptoglobin (HPG), serum amyloid A (SAA), malondialdehyde (MDA), adenosine deaminase (ADA), myeleperoxidase (MPO), aspartate aminotransferase (AST), creatine kinase (CK, creatine kinase–MB (CK‐MB), and gamma‐glutamyl transferase (GGT) activity increased significantly, and serum HPG, MDA, ADA, and AST concentrations increased significantly in the LDA group (P < .05). Peritoneal fluid HPG, MDA, ADA, MPO, ALP, GGT, and LDH concentrations increased significantly, whereas NO concentrations reduced significantly in the RDA group, and HPG, MDA, ADA, and TP concentrations increased significantly, whereas concentrations of NO reduced significantly in the LDA group (P < .05). Conclusions and Clinical Importance There are acute‐phase responses, oxidative stress, and abomasal tissue damage because of displacement in DA cases. Especially, HPG, MDA, ADA, and MPO concentrations can provide specific information to help in understanding these changes.

The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat

“…Liver enzymes (ALT, AST, GGT), oxidative stress index-OSI and TOS increases are marked in animals with fascielosis, while TAS decreases in serum and plasma samples (15). In this study, the levels of TAS and TOS were increased in the peritoneal fluid compared with serum samples (Table 3) and some data supported our findings (14,16). On the other hand, the level of enzymes was increased at the beginning of treatment, particularly parenchymal enzymes, reported by Braun (17).…”

NMR-based metabolomic evaluation in dairy cows with displaced abomasum

“…More recently, metabolites such as nonesterified fatty acids (NEFA) and BHB have been added to the profiles to monitor energy balance (6). There are acutephase responses, oxidative stress, and abomasal tissue damage in DA cases (7)(8)(9).…”

Evaluation of oxidative stress, antioxidant status and lipid profile in cattle with displacement of the abomasum

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