Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone

Zulkifli, I.; Najafi, P.; Nurfarahin, A. J.; Soleimani, A. F.; Kumari, Suchetha; Aryani, Any; O'Reilly, Emily; Eckersall, P. D.

doi:10.3382/ps.2014-04099

Cited by 57 publications

(39 citation statements)

References 47 publications

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“…Their work has shown that overcrowding of birds in cages leads to increased serum concentrations of ovarian venous plasma (OVT), AGP, and ceramide (CER). Zulkifli et al [69] reported that the serum concentration of AGP was nearly 60 ng/ml following administration of corticosterone to birds to induce a stress response. In the present study, such high values were not observed in the chickens in the control group nor in the groups receiving the zinc glycine chelate on any of the three assay days, so we rule out the effect of stress on the concentration of the APPs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Jarosz

Marek

Grądzki

et al. 2018

Biol Trace Elem Res

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The aim of the study was to determine how inorganic and organic forms of zinc affect the concentrations of C-reactive protein (CRP), serum amyloid A (SAA), alpha-1-acid glycoprotein (α-1-AGP), haptoglobin (Hp), and transferrin (TRF) in the blood and liver tissue of 450 1-day-old Ross 308 chicken. Four experimental groups received one the following: inorganic zinc (ZnSO 4 ), a zinc phytase enzyme supplement (ZnSO 4 -F), organic zinc in combination with glycine (Zn-Gly), or organic zinc supplemented with phytase (Zn-Gly-F). The chicken serum and liver homogenates were assayed using an ELISA kit. The results of the study showed statistically significantly higher serum and liver concentration of SAA in the group of birds that received zinc sulfate in comparison to the group of birds receiving zinc in organic form. A statistically significantly higher serum concentration of CRP and α-1-AGP was also noted in the group receiving zinc sulfate as compared to the Zn-Gly group. Comparison of the serum concentration of TRF between the supplemented groups showed a statistically significant increase in this parameter in the ZnGly-F group as compared to the ZSO 4 -F group. The increase in the serum concentration of Hp in all groups in comparison to the control may indicate stimulation of local immune mechanisms. The results of this study showed an increase in the concentrations of APPs such as AGP and TRF following the administration of zinc glycine chelates, which may demonstrate their effect on metabolic processes in the liver and on immunocompetent cells that regulate the intensity of the immune response.

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Section: Discussionmentioning

confidence: 99%

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Jarosz

Marek

Grądzki

et al. 2018

Biol Trace Elem Res

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“…described in details (Zulkifli et al 2014). The AGP concentration was determined using a commercial ELISA kit specific to chicken (Life Diagnostics Inc., West Chester, PA).…”

Section: Physiological Stress Indicatorsmentioning

confidence: 99%

Effects of protease supplementation of low protein and/or energy diets on growth performance and blood parameters in broiler chickens under heat stress condition

Law

Zulkifli

Farjam

et al. 2019

Italian Journal of Animal Science

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The effects of feeding low dietary crude protein (CP) and/or metabolisable energy (ME) with or without supplemental protease on growth performance, carcase characteristics and physiological responses in broiler chickens were investigated under cyclic heat stress condition. A total of 350 day-old male broiler chicks were fed with one of the following seven experimental diets: (1) recommended-CP and recommended-ME (RPE, served as control); (2) recommended-CP and low-ME (RPLE); (3) recommended-CP and low-ME with protease (RPLEP); (4) low-CP and recommended-ME (LPRE); (5) low-CP and recommended-ME with protease (LPREP); (6) low-CP and low-ME (LPE) and (7) low-CP and low-ME with protease (LPEP). From 22 to 42 d of age, half of the chickens from each dietary group were exposed to 34 ± 1 C for 7 h daily (heat stress), whereas the other half were raised at constant 23 ± 2 C (normal temperature). Supplementation of protease to RPLE, LPRE and LPE diets had no significant effects on feed intake (FI), weight gain (WG) or feed conversion ratio (FCR). Diet had no effect on serum glucose, total protein, certain acute phase proteins (APPs), corticosterone or breast yield. Regardless of protease supplementation, heat stressed birds had significantly lower FI, WG and breast yield, and higher FCR, APPs and corticosterone compared to birds raised in normal temperature. In conclusion, dietary supplementation of protease to low CP and/or ME diets showed negligible effects on growth performance, carcase characteristic and physiological responses in broiler chickens under heat stress condition. The inclusion of microbial protease in broiler diets could be considered by poultry industry as an effective nutritional tool for reducing ME or CP, in order to decrease abdominal fat deposition, improve feed efficiency and increase the profit margin. HIGHLIGHTS Protease supplementation has no specific help for broilers under heat stress. Feeding low CP and/or ME diet is not stressful for broiler chickens.

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“…Heat shock proteins (HSPs) are molecular chaperones that help maintain regular cellular functions by playing a crucial role in protein folding, unfolding, aggregation, degradation and transport (Beissinger and Buchner 1998;Sørensen et al 2003;Arya et al 2007). HSPs increase in response to acute and chronic stress, injury, and disease (Santoro 2000;Al-Aqil et al 2013;Zulkifli et al 2014). In particular, HSP60, 70 and 90 have been shown to be indicators of stress in several avian species, including Barn Swallows (Hirundo rustica), Broiler Chickens, and House Finches (Haemorhous mexicanus) (Merino et al 2002;Beloor et al 2010;Hill et al 2013;Wein et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Differential cell stress responses to food availability by the nestlings of Asian Short-toed Lark (Calandrella cheleensis)

et al. 2019

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Background: Timing of breeding season of temperate passerines has been considered to be adjusted to their food availability. There is little work to reveal the cell stress responses of the nestlings hatched asynchronized with the food abundance peak, which is important for understanding the physiological link between the timing of breeding and the fitness of offspring. Methods: Using gene expression level of blood HSP70 and HSP90 as indicators, we compared the cell stress response of Asian Short-toed Lark (Calandrella cheleensis) nestlings hatched under conditions of low, mid or high food (grasshopper nymph) availability in 2017. Results: Nymph biomass, sample time and interaction of these two factors significantly influenced the blood gene expression level of HSP70 and HSP90 of Asian Short-toed Lark nestlings. HSP70 and HSP90 gene expression levels of the nestlings at 14:00 were significantly higher than those at 5:00. At either 5:00 or 14:00, the gene expression levels of HSP70 and HSP90 increase with the decrease of nymph biomass. Conclusions: These results indicate that food availability is an important environment factor inducing cellular stress of Asian Short-toed Lark nestlings. The interactive effect of the nymph abundance and sample time on the HSPs response may be related with the daily temperature variation of the grassland. Over cell stress response may be one of physiological factor mediating the effect of food availability and the nestling's fitness.

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Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone

Cited by 57 publications

References 47 publications

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Effects of protease supplementation of low protein and/or energy diets on growth performance and blood parameters in broiler chickens under heat stress condition

Differential cell stress responses to food availability by the nestlings of Asian Short-toed Lark (Calandrella cheleensis)

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