Acute phase proteins in relation to various inflammatory diseases of calves

Tóthová, Csilla; Nagy, Oskar; Seidel, H.; Kováč, G.

doi:10.1007/s00580-011-1224-5

Cited by 17 publications

(17 citation statements)

References 22 publications

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“…The SAA concentrations have previously shown association with age [46] and diseases [14], but in this study there were no associations with any of the diseases and SAA concentrations. SAA is considered to be the most sensitive bovine APP [47], but in this study the results conflict.…”

Section: Acute Phase Proteins and The Diagnosescontrasting

confidence: 88%

“…In calves, research has concentrated on experimental and natural respiratory infections, where the association with the disease and the APPs has been confirmed [11,12]. Association between diarrhoea and increased APP concentrations or intestinal pathogens and increased APP concentrations has also been studied, but the results are inconclusive [13,14]. As severe tissue destruction occurs during eimeriosis, the acute phase response would be expected to follow [7].…”

Section: Introductionmentioning

confidence: 99%

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Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves

Seppä-Lassila

Orro

Lassen

et al. 2015

Comparative Immunology, Microbiology and Infectious Diseases

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In this study, the association between Eimeria spp. related signs and innate immune response in dairy calves was examined. Calves (n=100) aged 15-60 days were clinically examined and faecal samples, blood samples and deep nasopharyngeal swabs obtained. The samples were analysed for intestinal pathogens, acute phase proteins and WBC count, and respiratory tract pathogens, respectively. Diarrhoea was diagnosed in 32.6% (23.3-43.0%, 95% CI) of calves. An association between the pathogenic Eimeria spp. and diarrhoea was detected by multiple correspondence analysis. Eimeria related signs (diarrhoea, presence of pathogenic species and total oocyst count) were combined resulting a four level variable. Calves with weak signs of eimeriosis had decreased haptoglobin concentrations (p=0.02) and increased fibrinogen concentrations (p=0.048) compared to no signs. Increased haptoglobin and fibrinogen concentrations were associated with respiratory tract infection and umbilical infection. Serum amyloid A and WBC counts showed no association with signs of eimeriosis or clinical diagnoses.

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Section: Acute Phase Proteins and The Diagnosescontrasting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves

Seppä-Lassila

Orro

Lassen

et al. 2015

Comparative Immunology, Microbiology and Infectious Diseases

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“…L. Seppä-Lassila et al Livestock Science 196 (2017) 7-13 Presumably beef calves react to diseases similarly as dairy calves where associations between acute phase response and respiratory tract infections and umbilical infections have been reported (Nikunen et al, 2007;Tóthová et al, 2012;Seppä-Lassila et al, 2013). The low number of clinical diseases and low concentrations of especially Hp in this study restricted us from drawing any conclusions regarding associations between diseases and APPs.…”

Section: Clinical Diseases and Pathogens Of Intestinal And Respiratormentioning

confidence: 75%

Health and growth of Finnish beef calves and the relation to acute phase response

Seppä-Lassila

Eerola²,

Orro

et al. 2017

Livestock Science

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A B S T R A C THealthy, thriving calves are essential for beef calf production. We studied the health status and factors associated with the growth of beef calves in six cow-calf herds during the first month of the calves' lives and at weaning age (200 days).The six herds were visited three times, when calves were approximately 3 days, 16 days and 30 days of age. On each visit calves (n=37) were clinically examined, weighed or measured, blood samples were collected, faecal samples obtained and deep nasopharyngeal swabs were taken. Each blood sample was analysed for acute phase proteins (haptoglobin, serum amyloid-A, fibrinogen), total proteins and albumin, the faecal sample for intestinal tract pathogens (rotavirus, bovine coronavirus, enterotoxigenic Escherichia coli and Salmonella, oocysts of Eimeria coccidia and Cryptosporidium, and nematode eggs), and the nasopharyngeal swab for respiratory tract pathogens (bovine coronavirus (BCV), respiratory syncytial virus (RSV), bacteria and mycoplasma).Clinical diagnosis of respiratory tract disease, diarrhoea or umbilical disease was set at 15.0% for all the three consecutive examinations combined (n=107), but only few pathogens were detected from the samples. The increased levels of acute phase proteins were neither associated with any of the diseases nor with the pathogens. Random intercept linear models were used to explore factors affecting early (3-30 days) and long-term (3-200 days) growth, showing that calves with elevated serum amyloid-A concentrations at the age of 16 days had lower long-term growth. Increased albumin concentration at 30 days of age and higher parity of the dam increased early-term growth. The lack of association between a disease and the acute phase protein may stem from the low disease prevalence in the beef calves examined. The measurement of acute phase proteins of a young calf can help identify animals with possible future growth deficiencies, although the mechanisms through which the association between acute phase proteins and growth has yet to be explained.

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“…On the other hand, Hp concentration for anticipation of morbidity and mortality is determined to be 0.13 g/L in calves younger than 4 months (Murray et al, 2014). Hp concentrations have been reported to significantly increase in calves with pneumonia (Carter et al, 2002;Ganheim et al, 2003;Tothova et al, 2010;Tothova et al, 2012), enteritis (Balikci and Al, 2014), bovine respiratory disease (Joshi et al, 2018), pneumoenteritis (Ganheim et al, 2007), omphalophlebitis (Tothova et al, 2012), omphalitis (Bozukluhan et al, 2018), and neonatal diarrhoea (Pourjafar et al, 2011). In addition, Carter et al (2002) have stated that Hp concentrations are increased before treatment in the diseased calves compared to calves that received one or more than one treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In diseased calves, Fb is used to determine whether anti-inflammatory treatment is required (Humblet et al, 2004). In calves with pneumonia and multisystemic infection, Fb concentrations are increased compared to the control group but they did not change substantially in calves with omphalophlebitis (Tothova et al, 2012). Gokce et al (2015) have reported that calves with rotavirus enteritis had higher Fb concentrations than calves with enteritis caused by E. coli.…”

Section: Discussionmentioning

confidence: 99%

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

Kirbaş

Kandemir

Çelebi

et al. 2019

Acta Veterinaria Hungarica

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The objective of this study was to evaluate the usefulness of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia. The study material consisted of 13 neonatal calves with septicaemia (septicaemic calves, SC) and ten healthy neonatal calves (control calves, CC). Blood samples were collected for biochemical, haematological and microbiological analyses. In addition, faecal samples were collected for microbiological and virological analyses. Three of neonatal calves with septicaemia were positive for E. coli (E. coli O157 serotype) by microbiological examination, but all neonatal calves with septicaemia were negative for rota-and coronaviruses. By haematological examination, there were no significant differences between SC and CC for white blood cell (WBC) and neutrophil (NEU) counts (P > 0.05). NEU counts were higher on day 0 than on day 15 in SC (P < 0.05). Red blood cell (RBC) counts and packed cell volume (PCV) values were higher on day 0 in the SC than in the CC (P < 0.05). By biochemical analyses, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT), haptoglobin (Hp), and fibrinogen (Fb) concentrations were higher on day 0 in the SC than in the CC (P < 0.05). After treatment (on day 15), the serum IL-6, PCT, Hp, and Fb concentrations were significantly decreased in the SC compared to the CC (P < 0.05). The serum iron (Fe) concentrations were lower on day 0 in the SC than in the CC (P < 0.05), and were higher on day 15 than on day 0 in the SC (P < 0.05). The study revealed that inflammatory markers could be used for determining the diagnosis and prognosis in neonatal calves with septicaemia.

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Acute phase proteins in relation to various inflammatory diseases of calves

Cited by 17 publications

References 22 publications

Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves

Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves

Health and growth of Finnish beef calves and the relation to acute phase response

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

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