Acute Parietal and Chief Cell Changes Induced by a Lethal Dose of Lipopolysaccharide in Mouse Stomach before Thrombus Formation

Ito, Kyoko; Ishida, Katsuhiko; Shishido, Toetsu; Tabata, Hajime; Miura, Hisaki; Okamiya, Hideaki; Hanada, Takanori

doi:10.1177/019262330002800210

Cited by 1 publication

(1 citation statement)

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“…Comment: Vacuolation with no or minimal evidence of cell loss can be induced by agents that inhibit gastric acid secretion ( Dethloff et al 1997 ; Karam and Alexander 2001 ). In addition, degeneration is observed with anticancer cytotoxic agents, ulcerogenic agents and agents that decrease mucosal blood supply, or test articles that sequester in parietal cells ( Ito et al 2000 ; Bertram et al 2013 ; Greaves 2012 ). Depending on the nature and severity of the insult, degeneration will be followed by necrosis, erosion/ulcer of the epithelium, inflammation and/or hemorrhage.…”

Section: Stomachmentioning

confidence: 99%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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