Acute pancreatitis in elderly patients: a single-center retrospective evaluation of clinical outcomes

Quero, Giuseppe; Covino, Marcello; Fiorillo, Claudio; Rosa, Fausto; Menghi, Roberta; Simeoni, Benedetta; Potenza, Angelo Eugenio; Ojetti, Veronica; Alfieri, Sergio; Franceschi, Francesco

doi:10.1080/00365521.2019.1588369

Cited by 30 publications

(23 citation statements)

References 37 publications

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“…The framework of study incorporates a total of 150 patients suffering from pancreatitis. Among distinct age groups, the greatest proportion of patients hospitalized was under the age group of 20-50 years, followed by 51-60, more than 60 years the results found are supported by Jha et al [10] Regarding gender, males were found to be profoundly affected (93%) compared to females, similar findings were presented in the study by Pang et al [13], Quero et al [14], Broome et al [15], and Lankisch et al [16]. This may be due to life style of the males which differ from females.…”

Section: Discussionsupporting

confidence: 79%

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Assessment of Health-Related Quality of Life and Risk Factors Associated With Pancreatitis in a Tertiary Care Hospital

Rana

Kalyani

et al. 2021

Asian J Pharm Clin Res

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Objective: The objective of the study was to measure the health-related quality of life (HRQoL) in pancreatitis and to appraise the risk factors associated with the pancreatitis. Methods: A prospective observational study was performed with admitted cases of pancreatitis over 6 month’s period. A total of 150 patients were selected for the study. All data concerning risk factors were recorded and Short-Form-36 (SF-36) questionnaire was applied and quality of life (QOL) was analyzed in all patients with in study group. Results: All domains of (HRQoL) were assessed; it shows highest effect on role limitations due to physical health (36%), role limitations due to emotional problems (29%), role limitations due to physical health, and role limitations due to emotional problems (10%). Finally, our study revealed that there is a profound deterioration in physical components of QOL. The risk factors that majorly influence the QOL in association with disease were found to be alcohol consumption and smoking (70%). Conclusion: Pancreatitis remarkably diminishes the patient’s HRQoL which predominantly shows negative impact on physical health.

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Section: Discussionsupporting

confidence: 79%

“…Abdominal pain (100%) was the most pronounced symptom along with all other symptoms such as vomiting, diarrhea, and weight loss which was observed in our study population. This was supported by Quero et al [14], Sohn et al [23], and Wehler et al [24].…”

Section: Prasad Et Almentioning

confidence: 64%

Assessment of Health-Related Quality of Life and Risk Factors Associated With Pancreatitis in a Tertiary Care Hospital

Rana

Kalyani

et al. 2021

Asian J Pharm Clin Res

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“…Besides, an interesting phenomenon of the symptoms was evidenced in our study that dyspnea, jaundice and diarrhea presented more frequent in oldest patients as compared to older group (P < 0.05).The relation between AP and dyspnea symptoms in aging patients has been already reported [22]. While the other two symptoms of jaundice and diarrhea was not in line with previous research which reported that those symptoms was similar in older and oldest group.…”

Section: Discussioncontrasting

confidence: 46%

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

Lü¹,

Yu²,

Xie³

2020

Preprint

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Background The incidence of acute pancreatitis in aging patients has increasing in recent years. Controversial results about clinical outcomes of acute pancreatitis in aging patients were reported in different literature. The aim of our study was to compare the clinical outcomes of AP in aging patients between 60-79 years old and over 80 years old. Methods 80 patients aged ≥ 80 years old(oldest group) were compared to 393 patients aged 60 to 79 years old(older group). The clinical course, biochemical, radiological data were enrolled. The primary endpoint was to compare the death rate, intensive care unit admission rate and in-hospital length of stay(LOS). The secondary endpoint was operative treatment and the complications of AP. Results Abdominal symptom of abdominal pain (61.3% vs 46.3%, P=0.013) was less in oldest group, while diarrhea(18.3% vs 30.0%, P=0.018), jaundice(8.9% vs 17.5%, P=0.021), dyspnea(11.5% vs 26.3%, P=0.001) were more obvious in older group than oldest group. A higher death rate (8.9% vs 16.3%, P = 0.003) and longer hospital length of stay (11.51±10.19 vs 15.26±11.04, P = 0.001) were found in aging patients aged ≥80 years old. Mean BMI was lower in oldest group compared to older group(22.36±2.89 vs 21.07±3.18, P = 0.001). Multivariate analysis identified aged over 80 years(OR 3.299, 95%CI 1.316-8.269, P=0.011) and organ failure(P<0.05) as independent risk factors of mortality. More severe of AP(OR 11.722, 95%CI 4.780-28.764, P=0.001), abdominal pain(OR 1.906, 95%CI 1.052-3.453, P=0.033) and organ failure(P<0.05) were recognized as influencing intensive care unit rate. Aging patients aged over 80 years old(OR 0.149, 95%CI 2.027-6.268, P=0.001), more severe of AP(OR 0.218, 95%CI 1.567-4.322, P=0.001), female(OR 0.093, 95%CI 0.336-3.542, P=0.018), Jaundice(OR 0.080, 95%CI 0.146-5.324, P=0.038), operative treatment(P<0.05) and organ failure(P<0.05) were the risk factors for LOS.

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“…Patient-related risk factors include age (younger and older), female sex, normal serum bilirubin, recurrent pancreatitis, prior PEP, or those with sphincter of Oddi dysfunction[ 13 ]. While controversy surrounds age as risk factor for PEP, data have illustrated that pancreatitis in the elderly population could present differently and even be asociated with different outcomes[ 14 , 15 ]. Of note, patients with pancreas divisum may be at higher risk of acute pancreatitis which might influence clinical decision making with regard to the prophylactic measures taken to prevent PEP in this population[ 16 ].…”

Section: Predictors Of Pepmentioning

confidence: 99%

Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

Weissman¹,

Ahmed²,

Baniqued³

et al. 2021

WJGE

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Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions worldwide. With the widespread reliance on endoscopic retrograde cholangiopancreatography (ERCP) for the management of pancreaticobiliary conditions, post-ERCP pancreatitis (PEP) has come to represent an important etiology of acute pancreatitis. Despite many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder, findings have been heterogeneous, and considerable variation in clinical practice exists. Herein, we review the literature regarding PEP with the goal to raise awareness of this entity, discuss recent data, and present evidence-based best practices. We believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP.

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Acute pancreatitis in elderly patients: a single-center retrospective evaluation of clinical outcomes

Cited by 30 publications

References 37 publications

Assessment of Health-Related Quality of Life and Risk Factors Associated With Pancreatitis in a Tertiary Care Hospital

Assessment of Health-Related Quality of Life and Risk Factors Associated With Pancreatitis in a Tertiary Care Hospital

The clinical traits of acute pancreatitis in aging patients: a retrospective analysis of 473 cases

Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

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