Acute Pancreatitis following Extracorporeal Circulation

A, Panebianco; Scott, Stewart M.; Dart, Charles H.; Takaro, Timothy; Echegaray, H.Mario

doi:10.1016/s0003-4975(10)65551-8

Cited by 34 publications

(5 citation statements)

References 8 publications

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“…The above data are consistent with our findings concerning the incidence of pancreatitis, which was 3 % among the total number of liver transplant recipients; the mortality rate was 63.6 %. The incidence of biochemical pancreatitis, which was 16.4 %, did not appear to agree with the higher figures observed following cardiac surgery [16,24,26,29,34].…”

Section: Discussionmentioning

confidence: 75%

“…Proven pancreatitis, confirmed by evidence obtained from cr scan, operation, or autopsy, has been reported to vary between 0.12 % and 17 % following renal transplantation [8,10,14,25,28,35] and cardiac surgery [18,24,26,29,34] and has been associated with high mortality rates ranging between 20 % and 70 % [8,10,14,25,28,35]. The above data are consistent with our findings concerning the incidence of pancreatitis, which was 3 % among the total number of liver transplant recipients; the mortality rate was 63.6 %.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute pancreatitis after liver transplantation: incidence and contributing factors

et al. 1995

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In order to assess the incidence and possible predisposing and contributing factors in the development of acute pancreatitis after liver transplantation, we reviewed the medical records of all 1832 adult patients who underwent 2161 orthotopic liver transplantation (OLTx) procedures in our center between January 1987 and September 1992. Of these patients, 55 (3% incidence) developed clinical pancreatitis and 247 (13.4% incidence) developed hyperamylasemia (biochemical pancreatitis). Overall mortality in cases of clinical pancreatitis was 63.6%. The mortality in cases of hyperamylasemia was similar to that found in the general liver transplant population (i.e., 23%). A strong correlation was found between pancreatitis after liver transplantation and end‐stage liver disease due to hepatitis B (30% of the cases, P= 0.00001). Extensive surgical dissection around the pancreas (P < 0.05), the type of biliary reconstruction following liver transplantation (P < 0.05), and the number of liver grafts received by the same patient (P= 0.00001) appeared to be possible contributing factors as did the duration of venovenous bypass and the quantity of IV calcium chloride administered intraoperatively.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis after liver transplantation: incidence and contributing factors

et al. 1995

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“…Acute pancreatic injury has been well described in earlier studies in the setting of cardiac surgery [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. In this population, post-operative biochemical derangement (hyperamylasemia/hyperlipasemia) is prevalent, detected in nearly one third of patients [ 47 ].…”

Section: Studies On Pancreatic Injury In Heart Failurementioning

confidence: 93%

“…Additionally, hemodynamic factors, such as hypotension, low cardiac output, and increased bypass time, are independent predictors [ 47 ]. Although the presentation is usually subtle, severe (fulminating) pancreatitis has been documented in some patients [ 45 , 46 , 48 , 51 , 52 ]. The development of ischemic pancreatitis is associated with microvascular impairment and stasis, formation of thrombi, release of digestive enzymes and inflammation [ 53 , 54 ].…”

Section: Studies On Pancreatic Injury In Heart Failurementioning

confidence: 99%

Heart Failure and Pancreas Exocrine Insufficiency: Pathophysiological Mechanisms and Clinical Point of View

Dams

Vijver

Veldhuisen

et al. 2022

JCM

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Heart failure is associated with decreased tissue perfusion and increased venous congestion that may result in organ dysfunction. This dysfunction has been investigated extensively for many organs, but data regarding pancreatic (exocrine) dysfunction are scarce. In the present review we will discuss the available data on the mechanisms of pancreatic damage, how heart failure can lead to exocrine dysfunction, and its clinical consequences. We will show that heart failure causes significant impairment of pancreatic exocrine function, particularly in the elderly, which may exacerbate the clinical syndrome of heart failure. In addition, pancreatic exocrine insufficiency may lead to further deterioration of cardiovascular disease and heart failure, thus constituting a true vicious circle. We aim to provide insight into the pathophysiological mechanisms that constitute this reciprocal relation. Finally, novel treatment options for pancreatic dysfunction in heart failure are discussed.

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“…The relative proportion of "idiopathic" pancreatitis has diminished with time as the incidence of iatrogenic pancreatitis has increased. Drugs [1], cardiac surgery [2], and renal transplantation [3] are welldocumented etiological factors.…”

mentioning

confidence: 99%