Acute pancreatic injuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immunocell activation

Abstract

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The activation of AIM2/Caspase-1/GSDMD pathway contributes to pyroptosis of keratinocytes in Stevens-Johnson syndrome/toxic epidermal necrolysis

“…(33) IL-18 levels were signi cantly increased in the acute pancreatic injuries secondary to SJS/TEN compared with the nonpancreatitis individuals with SJS/TEN, that means in SJS/TEN, excessive pro-in ammatory cytokine IL-18 may cause acute pancreatic injuries. (34) The inhibition of pyroptosis is capable of reducing the IL-18 release into blood and might reduce the risk of acute pancreatic injuries complications. The concentrations of IL-1β and IL-18 in SJS/TEN acute-phase plasma advanced compared with healthy plasma and positively correlated with the SCORTEN score and the length of hospitalization of patients in our study.…”

5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review

“…Multiple organs can be involved, such as panophthalmitis, gastrointestinal bleeding, bronchopneumonia, pancreatitis, abnormal liver and kidney function, sepsis and even death. [ 19 , 20 ] Therefore, it is necessary to identify and avoid the development of SJS/TEN early.…”

Komplikasi Sindrom Stevens-Johnson (SSJ) dan Nekrolisis Epidermal Toksik (NET)

“…1,5 Komplikasi kronis SSJ/NET telah dilaporkan pada organ kulit, mata, selaput lendir mulut, pada organ internal termasuk paru (pneumonia), jantung (miokarditis), ginjal (nefritis), hepar (hepatitis), dan esofagus (striktur esofagus). 6,7 Kematian dikaitkan dengan tingkat keparahan pengelupasan kulit; tingkat kematian 1%-5% pada SSJ meningkat menjadi 25%-35% pada NET. 8 SSJ/ NET merupakan kondisi yang mengancam jiwa, yang mortalitasnya dikaitkan dengan usia yang lebih tua, total luas permukaan tubuh yang lebih terdampak, dan SCORTEN (severity-of-illness score for toxic epidermal necrolysis) yang lebih tinggi.…”

“…Peningkatan serum IL-12p70 dan TNF-α menunjukkan bahwa disregulasi sitokin sitotoksik mungkin menyebabkan cedera pankreas akut pada keadaan SSJ/NET. 7 Komplikasi Ginjal Komplikasi ginjal lebih sering pada pasien lebih tua dengan penyakit penyerta. Proteinuria, hematuria mikroskopis, uremia, azotemia, kadar serum urea >10 mmol/L merupakan faktor risiko independen untuk mortalitas pada fase akut SSJ/NET.…”