Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats

Lin, Xiaoying; Zhao, Jiating; Zhang, Wei; He, Liu; Wang, Liming; Chang, Dunhu; Cui, Liwei; Bai, Li; Chen, Chunying; Li, Yufeng

doi:10.1016/j.ecoenv.2019.110130

Cited by 61 publications

(37 citation statements)

References 52 publications

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“…Methylmercury (MeHg) is the most widely known contaminant of fish and can be a major concern with the consumption of certain species, especially for vulnerable populations including children and women who are pregnant or nursing. Gut microbes can modulate mercury toxicity through methylation and demethylation and may be able to decrease MeHg bioavailability (Lin et al, 2020;Rothenberg et al, 2016). Little difference was seen between the microbiota of human subjects with high stool MeHg compared to low, and any change in diversity was attributed to rare taxa (Rothenberg et al, 2016).…”

Section: Methylmercurymentioning

confidence: 99%

Understanding the effects of dietary components on the gut microbiome and human health

Rackerby

Kim

Dallas

et al. 2020

Food Sci Biotechnol

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The gut microbiome is the complex microbial ecosystem found in the gastrointestinal tract of humans and animals. It plays a vital role in host development, physiology and metabolism, and has been implicated as a factor in brain function, behavior, mental health, and many disease states. While many factors, including host genetics and environmental factors, contribute to the composition of the gut microbiome, diet plays a large role. Microorganisms differ in their nutrient requirements, and alterations in host dietary composition can have strong impacts on the microbial inhabitants of the gastrointestinal tract. The health implications of these dietary and microbial changes are relevant as various global populations consume diets comprised of different macronutrient ratios, and many diets promote alterations to recommended macronutrient ratios to promote health. This review will outline the ways in which specific macro- and micronutrients impact the gut microbiome and host health.

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Section: Methylmercurymentioning

confidence: 99%

Understanding the effects of dietary components on the gut microbiome and human health

Rackerby

Kim

Dallas

et al. 2020

Food Sci Biotechnol

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“…Studies with MeHg intoxication in 8-week old mice have shown reduced Firmicutes and increased Bacteroidetes numbers compared with non-intoxicated controls (Zhang et al, 2019). In contrast to the metagenomic data from Zhang and colleagues, Lie et al studies have found that MeHg-orally exposed young rats (10 µg/Kg) showed altered intestinal microbiota with reduced relative abundance of Bacteroidetes and Protobacteria and increases in Firmicutes (Lin et al, 2020). This discrepancy between both studies may be due to different animals and age groups used.…”

Section: Intestinal Microbiota Is Affected By Mehgmentioning

confidence: 93%

“…One form of modulation is the demethylation of MeHg into inorganic elements by the intestinal microbiota, which reduces Hg solubility in the tissue and hence bioavailability to the brain. The upregulation in Peptococcaceae family in the rat gut has been found to promptly demethylate MeHg and increase fecal excretion of Hg elements (Lin et al, 2020). Fecal excretion is one important way to eliminate Hg and prevent MeHg intoxication (Clarkson and Magos, 2006).…”

Section: Intestinal Microbiota Is Affected By Mehgmentioning

confidence: 99%

Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain

et al. 2020

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“…Generally, individuals are exposed via contaminated food consumption, particularly fish. Bioavailable organo-metallic compounds (e.g., MeHg) can cross the blood-brain and placental barriers, developing neurotoxicity (62,63).…”

Section: Mercurymentioning

confidence: 99%

Influence of toxic metal exposure on the gut microbiota (Review)

et al. 2021

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The gut microbiota (GM) is composed of >100 trillion different organisms, including bacteria, viruses, fungi, archaea and protists, coexisting in a complex system. The GM can be very sensitive to drugs, diet or even environmental pollutants. In the present review, recent data related to the interaction between the GM and heavy/toxic metals are discussed, focusing on the compounds most widely distributed in the environment or considered biopersistent. There are data to suggest that exposure to metals can alter the composition, diversity, homogeneity and structure of the GM. The specific modifications reported are not homogeneous, and a number of factors may explain this variability, including differences in metal compound, exposure modalities (e.g., food, water, in vitro), exposure time, qualitative and quantitative diversity of bacterial species in basal microbiota and analytical issues. As regards metal nanoparticles, some authors foresee the premises for a safe preventive and therapeutic use, while others have revealed harmful effects on both the gut microbiome and health. These findings, which would benefit from the application of modern approaches such as metagenomic sequencing and metabolomics, seem to indicate structural and functional analysis of gut microbiota as an early biomarker of detrimental effects from exposure to metals.

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Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats

Cited by 61 publications

References 52 publications

Understanding the effects of dietary components on the gut microbiome and human health

Understanding the effects of dietary components on the gut microbiome and human health

Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain

Influence of toxic metal exposure on the gut microbiota (Review)

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