Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain

Pinto, Daniel; Raposo, Ramon da Silva; Matos, Gabriella Araújo; Alvarez-Leite, Jacqueline I; Malva, João O.; Oriá, Reinaldo B.

doi:10.3389/fnins.2020.576543

Cited by 10 publications

(2 citation statements)

References 47 publications

(53 reference statements)

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“…This process may impact gut-mediated mercury elimination, through feces, and potentially trigger endotoxins release into the peripheral circulation. This cascade of events may be at the basis of a mounting peripheral inflammatory process and subsequent installation of central chronic neuroinflammation, further contributing to exacerbate MeHg-mediated central neurotoxic processes (Pinto et al, 2020). In addition, MeHg, is highly accumulated in the central nervous system (CNS) due to the special lipid content of the nervous tissue; therefore, MeHg easily reaches the brain due to its ability to cross the bloodbrain barrier (BBB), through a L-amino acid transporter (LAT-1) (Kerper et al, 1992; Figure 1) and upregulation of vascular endothelial growth factor (VEGF), reported to cause MeHginduced weakening of the BBB (Takahashi et al, 2017).…”

Section: The Environmental Impact Of Mercurymentioning

confidence: 99%

Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Raposo

Pinto

Moreira

et al. 2020

Front. Aging Neurosci.

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Worldwide environmental tragedies of anthropogenic origin causing massive release of metals and other pollutants have been increasing considerably. These pollution outbreaks affect the ecosystems and impact human health. Among those tragedies, recent large-scale environmental disasters in Brazil strongly affected riverside populations, leading to high-risk exposure to methylmercury (MeHg). MeHg is highly neurotoxic to the developing brain. This toxicant causes neural stem cell dysfunction and neurodevelopmental abnormalities. However, less is known about the effects of MeHg in the postnatal neurogenic niche, which harbors neural stem cells and their progeny, in the adult brain. Therefore, taking in consideration the impact of MeHg in human health it is urgent to clarify possible associations between exposure to mercury, accelerated cognitive decline, and neurodegenerative diseases. In this perspectives paper, we discuss the neurotoxic mechanisms of MeHg on postnatal neurogenesis and the putative implications associated with accelerated brain aging and early-onset cognitive decline in populations highly exposed to this environmental neurotoxicant.

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Section: The Environmental Impact Of Mercurymentioning

confidence: 99%

Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Raposo

Pinto

Moreira

et al. 2020

Front. Aging Neurosci.

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“…Environmental factors, such as pollutants, including brominated flame retardants, high metals, and herbicides, produce dysbiosis, which in turn, might potentially lead to the establishment of a pro-inflammatory state in the gut and consequently impact on a wide range of human pathologies, including neurological disorders [ 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 ].…”

Section: The Hypothesis Of the Enteric Route: From The Ingestion To T...mentioning

confidence: 99%

Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson’s Disease

2022

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Importance of a healthy lifestyle in maintaining the population’s well-being and health, especially in terms of balanced nutrition, is well known. Food choice of and dieting habits could impact disease management, which is especially true for Parkinson’s disease (PD). However, nowadays, it is not that simple to maintain a balance in nutrition, and the idea of a healthy diet tends to fade as the consequence of a western lifestyle. This should not only be dealt with in the context of food choice, but also from an environmental point of view. What we put into our bodies is strictly related to the quality of ecosystems we live in. For these reasons, attention should be directed to all the pollutants, which in many cases, we unknowingly ingest. It will be necessary to explore the interaction between food and environment, since human activity also influences the raw materials destined for consumption. This awareness can be achieved by means of an innovative scientific approach, which involves the use of new models, in order to overcome the traditional scientific investigations included in the study of Parkinson’s disease.

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Intestinal microbiota protects against methylmercury-induced neurotoxicity

Ke,

Rajoo,

Tinkov

et al. 2023

Biometals

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Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain

Cited by 10 publications

References 47 publications

Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson’s Disease

Intestinal microbiota protects against methylmercury-induced neurotoxicity

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