Acute Optic Neuritis in Demyelinating Diseases of the Nervous System

Berliner, Milton L.

doi:10.1001/archopht.1935.00840010093011

Cited by 23 publications

(7 citation statements)

References 6 publications

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“…For a clinician, detailed information on the typical scotoma patterns in ON is highly valuable for (differential) diagnostic purposes. Earlier reports concerning the patterns of the VFDs in ON are somewhat discordant, especially with regard to the frequency of central scotomas [4,10,13,14,16].…”

Section: Discussionmentioning

confidence: 83%

“…The question has also been raised as to whether ON has a predilection for certain axonal areas, thus causing the typical VF pattern [6]. In earlier studies performed with manual kinetic perimeters there has been a predominance of central scotomas [4,10,16], indicating a particular affection of the papillo-macular fibre bundle. However, in the ONTT study using automated static threshold estimating perimetry (Humphrey 30-2) [13,14], diffuse visual field defects were the most frequent finding (48%), followed by nerve fibre bundle defects (20%).…”

Section: Discussionmentioning

confidence: 99%

“…The VFDs associated with ON have been well documented in the publications of the Optic Neuritis Treatment Trial (ONTT) group [13,14] and in many preexisting articles [4,10,16]. According to these previous studies, there is marked variability in the frequency of different types of VFDs.…”

Section: Introductionmentioning

confidence: 99%

“…According to these previous studies, there is marked variability in the frequency of different types of VFDs. In many earlier studies, central and centrocecal scotomas, which were described as the hallmark of ON, seemed to be the most common findings [4,10,16]. However, in more recent studies based on automated static thresholding perimetry, diffuse VFDs were more frequent than central scotomas [6,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Visual field defects in acute optic neuritis - distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution

Nevalainen

Krapp

Paetzold

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Central scotomas and retinal nerve fibre bundle defects are the most common VFDs in acute ON. Small central and paracentral scotomas that most probably would have been missed by automated thresholding perimetry with its relatively coarse grid could be detected by threshold-related, slightly supraliminal strategy. Of the fellow eyes in clinically apparent monocular optic neuritis, 35% present with visual field defects.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Visual field defects in acute optic neuritis - distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution

Nevalainen

Krapp

Paetzold

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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“…Berliner [7], Carrol [8] and Marshall [9] stuften das zentrozokale Skotom and das zentrale Skotom als den haufigsten Gesichtsfelddefekt ein, den man bei Patienten mit einer Neuritis n. optici im Rahmen einer multiplen Sklerose finden kann. Sowohl Chamlin [10] and Hyllested [11], als auch Nikoskelainen [ 12] …”

Section: Introductionunclassified

Gibt es einen typischen Gesichtsfeldausfall bei Neuritis Nervi Optici?

Baradaran-Dilmaghani

Reitner

Ergun

1997

Spektrum Augeheilkd

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Zusammenfassung. Anhand von 80 Patienten mit klinisch typischen Symptomen einer Neuritis nervi optici wurde die Charakteristik and die Defekttiefe der initial erhobenen Gesichtsfeldbefunde ausgewertet. Neben der Visusprufung and der Untersuchung des vorderen and des hinteren Augenabschnittes wurde eine computerperimetrische Schwellenwertbestimmung des zentralen 30° Gesichtsfeldes durchgefuhrt (Humphrey Field Analyzer Program 30/2). Es wurden die Gesichtsfelder von insgesamt 20 mannlichen and 60 weiblichen Patienten beurteilt. Das Durchschnittsalter der Patienten lag bei 31,9 ± 11,3 Jahren. Bei 64% der Patienten handelte es sich um eine Erstmanifestation. Der Visus des betroffenen Auges bei bester Korrektur betrug 0,62 ± 0,47.In 86% der Falle handelte es sich um eine ausschlielllich monokulare Symptomatik, bei 14% waren die funktionellen Ergebnisse jedoch beiderseits pathologisch verandert. Es wurde ein ,,typisch" zentrozoekales Skotom nur bei 32% der Patienten gefunden, in alien anderen Fallen handelte es sich entweder um Quadrantenausfalle, Halbseitenausfalle, Faserverlaufsausfalle oder unspezifische Gesichtsfeldveranderungen. Das Vorliegen eines zentrozoekalen Skotoms ist bei einer Neuritis nervi optici mit dem Programm 30°/2 (Humphrey) keineswegs obligat. Die Anamnese, das Lebensalter, das Vorliegen der typischen Schmerzsymptomatik and vor allem der zeitliche Verlauf der funktionellen Storung, MRI and Liquordiagnostik sichern die Diagnose.Schlasselworter: Neuritis n. optici, Computerperimetrie, multiple Sklerose, Gesichtsfeld. Is there any typical visual field defect in optic nerve neuritis?Summary. Eighty patients were evaluated with typical symptoms of acute optic neuritis and the type and depth of the defect in the initial visual field findings were characterized.Anterior and posterior eye segments as well as visual acuity were examined. Additionally we assessed visual fields for the central 30° by computer assisted perimetry using Humphrey Allergan automated Field Analyzer, Program 30°/2 (Humphrey Allergan). The visual fields of 20 male and 60 female individuals were evaluated, the mean age being 31.9 ± 11.3 years. In 63.4% of our patients this was the first episode, in 36.4% had a recurrent optic neuritis. The average visual acuity of the affected eye was 0.62 ± 0.47 (Snellen) after optimal correction of refractive abnormalities. In 86%, the symptoms were monocular, whereas in the remaining 14% the function of both eyes was affected.A "typical" cecocentral scotoma was seen in only 32% of the cases. Quadrananopia, heminanopia, isolated nerve fibre defects or non-specific visual field defects were found in the remaining 68%. Thus, the presence of a cecocentral scotoma does not seem to be mandatory in optic neuritis or could not be acertained reliably when using program 30°/2. The patient's history, age, cranial MRI and primarily the timeframe of the functional loss secure the diagnosis of the disease.

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Parainfectious Optic Neuritis

Selbst¹

1983

Arch Neurol

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Acute Optic Neuritis in Demyelinating Diseases of the Nervous System

Cited by 23 publications

References 6 publications

Visual field defects in acute optic neuritis - distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution

Visual field defects in acute optic neuritis - distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution

Gibt es einen typischen Gesichtsfeldausfall bei Neuritis Nervi Optici?

Parainfectious Optic Neuritis

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